Carolyn Kramer Ph.D.

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Carolyn Kramer

Postdoctoral Associate

Address: Boston University Department of Medicine, Section of Infectious Diseases. 650 Albany st. X-620. Boston, MA 02118

Email: ckramer8@bu.edu

Office: 617-414-5382

 

Education:

Ph.D. The University of Memphis, Memphis, TN
B.S. Cornell University, Ithaca, NY

Research:

Dr. Kramer is investigating the role of the innate immune system in the Porphyromonas gingivalis-induced development and progression of periodontal disease and atherosclerosis, two chronic inflammatory diseases. Interleukin-1 (IL-1) is an important mediator of the pro-inflammatory response to pathogens; Dr. Kramer is studying the role of IL-1 signaling on oral inflammatory bone loss and atherosclerotic plaque progression in response to the oral pathogen, P. gingivalis. Specifically, the divergent roles of IL-1alpha and IL-1beta in local vs. systemic inflammation will be defined. Dr. Kramer is also investigating the genome-wide gene expression changes in aortae of mice subjected to 3 separate inducers of atherosclerosis: Porphyromonas gingivalis, Chlamydophila pneumoniae, and high-fat diet.

Publications:

Papadopoulos, G.*, Kramer, C.*, Slocum, C., Weinberg, E., Hua, N., Gudino, C.V., Hamilton, J.A., C.A. Genco.  A Mouse Model for Pathogen-Induced Chronic Inflammation at Local and Systemic Sites. Journal of Visualized Experiments (JoVE). 2014. In Press.

Slocum CS, Coats R, Hua N, Kramer C, Papadopolous G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA.  Distinct lipid A moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS pathogens. 2014 July 2014; 10(7): e1004215. Full Text

Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):552-64.  Abstract / Full Text

Poole NM, Nyindodo-Ogari L, Kramer C, Coons LB, Cole JA. Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells.Ticks Tick Borne Dis. 2013 Feb;4(1-2):120-7. PMID: 23168047 Abstract

Kramer CD, Poole NM, Coons LB, Cole JA. Tick Saliva Regulates Migration, Phagocytosis, and Gene Expression in the Macrophage-like Cell Line, IC-21. Exp Parasitol. 2011 Mar; 127(3):665-71. PMID: 21145320 Abstract

Kramer C, Nahmias Z, Norman DD, Mulvihill TA, Coons LB, Cole JA. Dermacentor variabilis: regulation of fibroblast migration by tick salivary gland extract and saliva. Exp Parasitol. 2008 Jul;119(3):391-7. PMID: 18492598 Abstract

Contact|Directory|BUMC
July 22, 2014
Primary teaching affiliate
of BU School of Medicine