Publications

FTMS publications (reverse chronological order):

Most of these publications include a link to the publisher’s website where the publication can be downloaded. However, if you can’t get the publication directly, please email me and I’ll forward the .pdf file to you.

  • Publications (reverse chronological order):

    68. Mathur, R.; Knepper, R. W.; O’Connor, P. B. A low noise, broadband cryogenic preamplifier operated in a high field superconducting magnet IEEE Transactions on Applied Superconductivity 2008, submitted. .

  • 67. Li, X.; Cournoyer, J. C.; Lin, C.; O’Connor, P. B. The effect of fixed charge modifications on electron capture dissociation J. Am. Soc. Mass Spectrom. 2008, in revision. .
  • 66. Li, X.; Cournoyer, J. C.; Lin, C.; O’Connor, P. B. Use of 18o labels to monitor deamidation during protein and peptide sample processing J. Am. Soc. Mass Spectrom. 2008, in press. .
  • 65. Cournoyer, J. C.; Lin, C.; O’Connor, P. B. Gas-phase structure dissimilarity of protonated isomeric peptides revealed by ir-activated dr-ecd J. Am. Soc. Mass Spectrom. 2008, in press. .
  • 64. Lin, C.; Cournoyer, J. C.; O’Connor, P. B. Probing the gas phase folding kinetics of peptide ions by ir-activated dr-ecd J. Am. Soc. Mass Spectrom. 2008, in press. .
  • 63. Xie, B.; Luo, X.; Zhao, C.; Priest, C. M.; Chan, S.-Y.; O’Connor, P. B.; Kirschner, D. A.; Costello, C. E. Molecular characterization of myelin protein zero in xenopus laevis peripheral nerve: Equilibrium between non-covalently associated dimer and monomer Int. J. Mass Spectrom. Ion Processes 2007, 268, 304-315 .
  • 62. Lin, C.; Mathur, R.; Aizikov, K.; O’Connor, P. B. First signal on the cryogenic fourier-transform ion cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2090-2093 Link.
  • 61. Mathur, R.; Knepper, R. W.; O’Connor, P. B. A low-noise, wideband preamplifier for a fourier-transform ion cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2233-2241 Link.
  • 60. Aizikov, K.; Mathur, R.; O’Connor, P. B. The spontaneous loss of coherence catastrophe in fourier transform ion cyclotron resonance mass spectrometry 2007, in revision.
  • 59. Zhao, C.; Cournoyer, J.; Xie, B.; Zaia, J.; Costello, C. E.; O’Connor, P. B. Structural analysis of milk oligosaccharides and n-linked branched glycans by electron detachment dissociation 2007, in revision.
  • 58. Zhao, C.; Xie, B.; Chan, S.-Y.; Costello, C. E.; O’Connor, P. B. Collisionally activated dissociation and electron capture dissociation provide complementary structural information for permethylated oligosaccharides J. Am. Soc. Mass Spectrom. 2007, 19, 138-150 Link.
  • 57. Zhao, C.; O’Connor, P. B. Removal of polyethylene glycols from protein samples using titanium dioxide Anal. Biochem. 2007, 365, 283-285 .
  • 56. Cournoyer, J. J.; O’Connor, P. B. In Post-translational modifications; Whitelegge, J. P., Ed., 2007, in press.
  • 55. O’Connor, P. B. In Electrospray ionization mass spectrometry; Cole, R. B., Ed.; Wiley Interscience, 2007 in press.
  • 54. O’Connor, P. B.; Hillenkamp, F. In Maldi-ms; Hillenkamp, F., Peter-Katalinic, J., Eds.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2007, pp 29-82.
  • 53. Kaur, P.; O’Connor, P. B. Quantitative determination of isotope ratios from experimental isotopic distributions Anal. Chem. 2007, 79, 1198-1204 Link.
  • 52. Mathur, R.; O’Connor, P. B. Design and implementation of a high power rf oscillator on a printed circuit board for multipole ion guides Rev. Sci. Instrum. 2006, 77, 114101 Link.
  • 51. Kaur, P.; O’Connor, P. B. Comparison of charge state determination methods for high resolution mass spectra IEEE Int. Conf. on Granular Computing May 10, 2006, 550-553 .
  • 50. Cournoyer, J. C.; Lin, C.; Bowman, M. J.; O’Connor, P. B. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation J. Am. Soc. Mass Spectrom. 2006, in press, online Sept. 25, 2006. Link.
  • 49. Belyayev, M. A.; Cournoyer, J. J.; Lin, C.; O’Connor, P. B. The effect of radical trap moieties on electron capture dissociation spectra of substance p J. Am. Soc. Mass Spectrom. 2006, 17, 1428-1436 Link.
  • 48. Lin, C.; Cournoyer, J. J.; O’Connor, P. B. Use of a double resonance electron capture dissociation experiment to probe fragment intermediate lifetimes J. Am. Soc. Mass Spectrom. 2006, in press, online August 9, 2006. Link.
  • 47. Zhao, C.; Sethuraman, M.; Clavreul, N.; Kaur, P.; Cohen, R. A.; O’Connor, P. B. A detailed map of oxidative post-translational modifications of human p21ras using fourier transform mass spectrometry Anal. Chem. 2006, published online June 14 Link.
  • 46. Aizikov, K.; O’Connor, P. B. Use of the filter diagonalization method in the study of space charge related frequency modulation in ftms J. Am. Soc. Mass Spectrom. 2006, 17, 836-843 Link.
  • 45. O’Connor, P. B.; Cournoyer, J. J.; Pitteri, S. J.; Chrisman, P. A.; McLuckey, S. A. Differentiation of aspartic and isoaspartic acids using electron transfer dissociation J. Am. Soc. Mass Spectrom. 2006, 17, 15-19 Link.
  • 44. Perlman, D. H.; Berg, E. A.; O’Connor, P. B.; Costello, C. E.; Hu, J. Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids Proc. Nat. Acad. Sci. USA 2005, 102, 9020-9025 Link.
  • 43. O’Connor, P. B.; Lin, C.; Cournoyer, J. J.; Pittman, J. L.; Belyayev, M.; Budnik, B. A. Long-lived electron capture dissociation product ions experience radical migration via hydrogen abstraction J. Am. Soc. Mass Spectrom. 2006, 17, 576-585 Link.
  • 42. Kaur, P.; O’Connor, P. B. Algorithms for automatic interpretation of high resolution mass spectra J. Am. Soc. Mass Spectrom. 2006, 17, 459-468 Link.
  • 41. Cournoyer, J. J.; Lin, C.; O’Connor, P. B. Detecting deamidation products in proteins by electron capture dissociation Anal. Chem. 2006, 78, 1264-1271 .Link.
  • 40. O’Connor, P. B.; Cournoyer, J. J.; Pitteri, S. J.; Chrisman, P. A.; McLuckey, S. A. Differentiation of aspartic and isoaspartic acids using electron transfer dissociation J. Am. Soc. Mass Spectrom. 2006, 17, 15-19 .Link
  • 39. O’Connor, P. B.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Cournoyer, J. C.; Jebanathirajah, J.; Lin, C.; Moyer, S.; Zhao, C. A new hybrid electrospray Fourier transform mass spectrometer: Design and performance characteristics Rapid Commun Mass Spectrom 2006, 20, 259-266.
  • 38. Jebanathirajah, J. A.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Kaur, P.; Rape, M.; Kirschner, M.; Costello, C. E.; O’Connor, P. B. Characterization of a new qqq-fticr mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins J. Am. Soc. Mass Spectrom. 2005, 16, 1985-1999 Link.
  • 37. Ivleva, V. B.; Sapp, L. M.; O’Connor, P. B.; Costello, C. E. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 1552-1560 Link.
  • 36. Cournoyer, J. J.; Pittman, J. L.; Ivleva, V. B.; Fallows, E.; Waskell, L.; Costello, C. E.; O’Connor, P. B. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation Protein Science 2005, 14, 452-463.
  • 35. Pittman, J. L.; O’Connor, P. B. A minimum thickness gate valve with integrated ion optics for mass spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 441-445 Link.
  • 34. Moody, D. B.; Young, D. C.; Cheng, T.-Y.; Rostat, J.-P.; Roura-mir, C.; O’Connor, P. B.; Zajonc, D. M.; Walz, A.; Miller, M. J.; Levery, S. B.; Wilson, I. A.; costello, C. E.; Brenner, M. B. T-cell activation by lipopeptide antigens Science 2004, 203, 527-531. Link
  • 33. Kaur, P.; O’Connor, P. B. Use of statistical methods for quantitative determination of the number of trapped ions Anal. Chem. 2003, 76, 2756-2762.
  • 32. Budnik, B. A.; Moyer, S. C.; Pittman, J. L.; Ivleva, V. B.; Sommer, U.; Costello, C. E.; O’Connor, P. B. High pressure maldi-ftms: Implications for proteomics Int. J. Mass Spectrom. Ion Processes 2004, 234, 203-212.
  • 31. Ivleva, V. B.; Elkin, Y. N.; Budnik, B. A.; Moyer, S. C.; O’Connor, P. B.; Costello, C. E. Coupling thin layer chromatography with high pressure matrix assisted laser desorption/ionization fourier transform mass spectrometry for the analysis of ganglioside mixtures Anal. Chem. 2004, 76, 6484-6491.
  • 30. O’Connor, P. B.; Budnik, B. A.; Ivleva, V. B.; Kaur, P.; Moyer, S. C.; Pittman, J. L.; Costello, C. E. A High Pressure Matrix-Assisted Laser Desorption Fourier Transform Mass Spectrometry Ion Source Designed to Accommodate Large Targets with Diverse Surfaces J Am Soc Mass Spectrom 2003, 15, 128-132.
  • 29. Moyer, S. C.; Budnik, B. A.; Pittman, J. L.; Costello, C. E.; O’Connor, P. B. Attomole Peptide Analysis by High Pressure Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry Anal Chem 2003, 75, 6449-6454.
  • 28. Leymarie, N.; Costello, C. E.; O’Connor, P. B. Electron Capture Dissociation Initiates a Free Radical Reaction Cascade J. Am. Chem. Soc. 2002, 125, 8949-8958.Link
  • 27. O’Connor, P. B.; Costello, C. A.; Earle, W. E. A high voltage rf oscillator for driving multipole ion guides J. Am. Soc. Mass Spectrom. 2002, 13, 1370-1375 Link.
  • 26. Leymarie, N.; Berg, E. A.; McComb, M. E.; O’Connor, P. B.; Grogan, J.; Oppenheim, F. G.; Costello, C. E. Tandem Mass Spectrometry for Structural Characterization of Proline-Rich Proteins: Application to Salivary PRP-3 Anal. Chem. 2002, 74, 4124-4132. Link
  • 25. Hopkins, C. E.; O’Connor P, B.; Allen, K. N.; Costello, C. E.; Tolan, D. R. Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase Protein Sci 2002, 11, 1591-1599. Link
  • 24. McClellan, J. E.; Costello, C. E.; O’Connor, P. B.; Zaia, J. Influence of Charge State on Product Ion Mass Spectra and the Determination of 4S/6S Sulfation Sequence of Chondroitin Sulfate Oligosaccharides Anal. Chem. 2002, submitted. Link
  • 23. O’Connor, P. B. Considerations for the design of a Fourier Transform mass spectrometer in the 4.2K cold bore of a superconducting magnet Rapid Commun Mass Spectrom 2002, 16, 1160-1167. Link
  • 22. Mirgorodskaya, E.; O’Connor, P. B.; Costello, C. E. A general method for precalculation of parameters for sustained off resonance irradiation/collision-induced dissociation J. Am. Soc. Mass Spectrom. 2002, 13, 318-324 Link.
  • 21. (O’Connor, P. B.; Mirgorodskaya, E.; Costello, C. E. High pressure matrix-assisted laser desorption/ionization fourier transform mass spectrometry for minimization of ganglioside fragmentation J. Am. Soc. Mass Spectrom. 2002, 13, 402-407 Link.
  • 20. Lim, A.; Prokaeva, T.; McComb, M. E.; O’Connor, P. B.; Theberge, R.; Connors, L. H.; Skinner, M.; Costello, C. E. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis Analytical Chemistry. 2002, 74, 741-751. Link
  • 19. O’Connor, P. B.; Costello, C. E. A High Pressure Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry Ion Source for Thermal Stabilization of Labile Biomolecules Rapid Commun. Mass Spectrom. 2001, 15, 1862-1868.
  • 18. van den Brink, O. F.; Boon, J. J.; O’Connor, P. B.; Duursma, M. C.; Heeren, R. M. A. Matrix-assisted laser desorption/ionization Fourier transform mass spectrometric analysis of oxygenated triglycerides and phosphatidylcholines in egg tempera paint dosimeters used for environmental monitoring of museum display conditions J. Mass Spectrom. 2001, 36, 479-492.
  • 17. O’Connor, P. B.; Costello, C. E. Application of multishot acquisition in fourier transform mass spectrometry Anal. Chem. 2000, 72, 5125-5130.
  • 16. O’Connor, P. B.; Costello, C. E. Internal calibration on adjacent samples (InCAS) with Fourier transform mass spectrometry Anal. Chem. 2000, 72, 5881-5885.
  • 15. O’Connor, P. B.; Duursma, M. C.; Rooij, G. J. v.; Heeren, R. M. A.; Boon, J. J. Correction of Time of flight shifted polymeric molecular weight distributions in MALDI-FTMS Anal. Chem. 1997, 69, 2751-2755.
  • 14. Guan, Z.; Kelleher, N. L.; O’Connor, P. B.; Aaserud, D. J.; Little, D. P.; McLafferty, F. W. 193 nm Photodissociation of Larger Multiply Charge Biomolecules Int. J. Mass Spectrom. Ion Processes 1996, 157/158, 357-364.
  • 13. Moertz, E.; O’Connor, P. B.; Roepstorff, P.; Kelleher, N. L.; Wood, T. D.; McLafferty, F. W.; Mann, M. Sequence Tag Identification of Intact Proteins by Matching Tandem Mass Spectral Data Against Sequence Databases Proc. Nat. Acad. Sci. USA 1996, 93, 8264-8267.
  • 12. O’Connor, P. B.; McLafferty, F. W. Oligomer Characterizationof 4-22 kDa Polymers by Electrospray Fourier-Transform Mass Spectrometry J. Am. Chem. Soc. 1996, 117, 12826-12831.
  • 11. O’Connor, P. B.; Speir, J. P.; Wood, T. D.; Chorush, R. A.; Guan, Z.; McLafferty, F. W. Quadrupolar Axialization of Large Multiply Charged Ions J. Mass Spectrom. 1996, 31, 555-559.
  • 10. Aaserud, D. J.; Little, D. P.; O’Connor, P. B.; McLafferty, F. W. Distinguishing N- and C- Terminus Ions for Mass Spectrometry Sequencing of Proteins without Prior Degradation Rapid Commun. Mass Spectrom. 1995, 9, 871-876.
  • 9. Kelleher, N. L.; Senko, M. W.; Little, D. P.; O’Connor, P. B.; McLafferty, F. W. 50 fmol Complete Large Molecule High Resolution J. Am. Soc. Mass Spectrom. 1995, 6, 220-221.
  • 8. McLafferty, F. W.; Senko, M. W.; Little, D. P.; Wood, T. D.; O’Connor, P. B.; Speir, J. P.; Chorush, R. A.; Kelleher, N. L. Electrospray Ionization and Fourier Transfrom Mass Spectrometry in Biomedical Research Adv. Mass Spectrom. 1995, 13, 115-128.
  • 7. O’Connor, P. B.; Little, D. P.; McLafferty, F. W. Isotopic Assignment in Large Molecule Mass Spectra by Fragmentation of a Selected Isotopic Peak Anal. Chem. 1995, 68, 542-545.
  • 6. O’Connor, P. B.; McLafferty, F. W. High Resolution Ion Isolation with the Capacitively Coupled open cell J. Am. Soc. Mass Spectrom. 1995, 6, 533-535.
  • 5. O’Connor, P. B.; Speir, J. P.; Senko, M. W.; Little, D. P.; McLafferty, F. W. Tandem Mass Spectrometry of Carbonic Anhydrase (29 kDa) J. Mass Spectrom. 1995, 30, 88-93.
  • 4. Wood, T. D.; Chorush, R. A.; Wampler, F. M. I.; Little, D. P.; O’Connor, P. B.; McLafferty, F. W. Gas Phase Folding and Unfolding of Cytochrome c Cations Proc. Nat. Acad. Sci. USA 1995, 92, 2451.
  • 3. Little, D. P.; Speir, J. P.; Senko, M. W.; O’Connor, P. B.; McLafferty, F. W. Infrared Multiphoton Dissociation of Large Multiply-Charged Ions for Biomolecule Sequencing Anal. Chem. 1994, 66, 2809-2815.
  • 2. Marshall, P.; O’Connor, P. B.; Chan, W.-T.; Kristof, P. B.; Goddard, J. D. In Gas Phase Metal Reactions; Fontijn, A., Ed.; Elsevier: Amsterdam, 1992.
  • 1. Cioslowski, J.; O’Connor, P. B.; Fleischmann, E. D. Is Superbenzene Superaromatic? J. Am. Chem. Soc. 1991, 113, 1086.
  • Patents :
    1. O’Connor, P. B. Apparatus and Method for Ion Cyclotron Resonance Mass Spectrometry USA 2003 10/338423

Primary teaching affiliate
of BU School of Medicine