NANOTHERANOSTICS

INITIATION DATE:

1.1.12

ARC DIRECTORS AND CO-DIRECTORS

Mark Grinstaff, PhD Professor Chemistry, Biomedical Engineering, BU-CRC (mgrin@bu.edu)

Joyce Y. Wong, PhD Associate Professor Biomedical Engineering, BU-CRC (jywong@bu.edu)

Karl J. Karlson, MD, MMSc Chief, Cardiac Surgery Cardiac Surgery, Surgery, BUSM (kkarlson@bu.edu)

Victoria L.M. Herrera, MD Professor Cardiology, Medicine, BUSM (vherrera@bu.edu)

OVERVIEW OF GOALS AND MISSION:

Rationale:

Establishing a Nanotheranostics ARC is important because nanotheranostics, defined as the integrated combination of target-specific diagnostics and delivery of therapeutics based on nanotechnology platforms, could provide a potential high-impact nanomedicine paradigm for addressing current treatment roadblocks and persistent clinical needs, which are not successfully addressed with current approved technologies. The ARC-program provides the optimal avenue to develop nanotheranostics research since nanotheranostics requires a multidisciplinary approach.

nanomedicine

 

Briefly, the design of the nano-theranostic platform requires an understanding of the following at the outset: the nanotechnology potential, the accessible molecular target(s) and high-value therapeutics in the context of disease progression complexities, the clinically pertinent targeted-imaging, the clinically feasible targeted-delivery, and the needed preclinical model for testing in vivo efficacy and safety. While daunting, thechallenges are exciting. As members of the Nanotheranostics ARC, we seek the opportunity to meet the challenges of nanomedicine. Importantly, we have prototype nanotechnology platforms (expansile nanoparticles (NPs), nanowire-mesh, nanogels [M. Grinstaff], nanoemulsion formulations [JB Tagne, T. Porter], Janus-NP/microbubble polyplexes [J.Wong, V.Herrera, N.Ruiz-Opazo] – all of which have shown in vitro and vivo efficacy delivering drugs and DNA (respectively), and proof of concept imaging formats.

In summary, our proposed ARC benefits from, and complies with the interdisciplinary mission of the Evans Center – involving clinicians, biomedical researchers and engineers, and involving co-directors who each represent a different discipline. The ARC initiative got us brainstorming together and we have more ideas than time and budget would permit. Appreciative of the opportunities created and that we are uniquely poised, we are committed to developing nanotheranostics research at BU.

ARC MEMBERS:

ARC co-Directors

Name Title Section / Department(s)
1 Mark Grinstaff, PhD Professor Chemistry, Biomedical Engineering, BU-CRC
2 Joyce Y. Wong, PhD Professor Biomedical Engineering, BU-CRC
3 Karl J. Karlson, MD, MMSc Chief, Cardiac Surgery Cardiac Surgery, Surgery, BUSM
4 Victoria L.M. Herrera, MD Professor Cardiology, Medicine, BUSM

ARC members (alphabetical order per expertise category)

Nanosciences and Nanotechnology (*core faculty)

Name

Title

Department

1* Mark Grinstaff, PhD Professor Chemistry, Biomedical Engineering, BU-CRC
2* Joyce Y. Wong, PhD Professor Biomedical Engineering, BU-CRC
3* Tyrone M. Porter, PhD Assoc. Professor, Assoc. Director of CNN Mechanical Engineering, BU-CRC
4* Jean-Bosco Tagne, PhD Assistant Professor Pulmonary Medicine, Medicine, BUSM
Basic Sciences / Translational Research

Name

Title

Section, Department

5 William Cruikshank, PhD Professor Section of Pulmonary Medicine, Medicine
6* Victoria Herrera, MD Professor Section of Cardiology, Medicine
7 Katya Ravid, PhD Professor, Director Evans Center for IBR Whitaker Cardiovascular Institute, Medicine, Biochemistry, Evans Center for IBR
8* Nelson Ruiz-Opazo, PhD Professor Section of Cardiology, Department of Medicine, BUSM
9* Richard Wainford, PhD Assistant Professor Department of Pharmacology
10 Orian Shirihai, PhD Assoc. Professor Medicine
Clinical Sciences: Surgery, Medicine, Radiology

Name

Title

Section, Department

11 Alik Farber, MD Associate Professor, Chief Vascular Surgery Vascular Surgery, Surgery, BUSM
12* Karl J. Karlson, MD, MMSc Chief, Cardiac Surgery Cardiothoracic Surgery, Surgery, BMC
13 Elizabeth Klings, MD Assistant Professor Section of Pulmonary Medicine, Department of Medicine, BUSM
14* B. Nicolas Bloch Assistant Professor Radiology, BUSM
External Advisors, Consultants, Collaborators
Gregory Lanza, MD, PhD Professor of Medicine Washington University, St. Louis, MO
Michael Obrien, MD Professor of Pathology Department of Pathology, BUSM
David McAneny, MD Associate Professor Department of Surgery, BMC
Yolanda Colson, MD Associate Professor Department of Surgery, BWH, Harvard Medical School
Patrick Y. Wen, MD Professor of Neurology, Director, Center for Neuro-Oncology Dana Farber Cancer Center, Harvard Medical School
15* Deborah Burstein, PhD Associate Professor, Radiology Beth Israel Deaconess Medical Center, Harvard Medical School
16 Maria Jose Alonso, PhD Professor University of Santiago de Compostela, Spain
17 Marcos Fuentes Garcia, PhD Associate Professor University of Santiago de Compostela, Spain
Contact|Directory|BUMC
March 28, 2014
Primary teaching affiliate
of BU School of Medicine