In the Androgen Clinical Research Unit (ACRU), NIH-funded research studies include: Testosterone Dose Response in Surgically Menopausal Women (TDSM Study), The Role of 5 Alpha Reductase in Mediating Testosterone Actions (5 AR Study), Effects of Testosterone Replacement on Muscle Performance and Physical Function in Older Men (TOM Study), Testosterone and Physical Function in Men on Hemodialysis (ESRD Study), Effects of Testosterone Replacement on Atherosclerosis Progression in Older Men with Low Testosterone Levels (TEAAM Study), and Testosterone Modulation of Response to Selective Phosphodiesterase Inhibitors.
Muscle and Aging Research Unit (MARU)
The Muscle and Aging Research Unit was established to spearhead interdisciplinary translational research to foster the development of anabolic therapies for functional limitations associated with aging and chronic diseases. MARU’s current research focus is in investigating the mechanisms by which androgens regulate mesenchymal stem cell differentiation. The Biophotonics Laboratory led by Ravi Jasuja, Ph.D., uses a variety of biophysical techniques to investigate the energetics of the conformational change associated with androgen binding to the androgen receptor. Dr. Jasuja is developing optical spectroscopy instrumentation to study the molecular fingerprints of ligand:receptor interactions in androgen receptor signaling pathway. The instrumentation utilizes components from photoaoustics, photothermal beam deflection and time resolved emission spectroscopies. Combined with the fluorescence lifetime imaging capabilities, these measurements will elucidate the structural and thermodynamic determinants for rational design of Selective Androgen Receptor Modulators for anabolic therapies.
Laboratory of Exercise Physiology and Physical Performance (LEP3)
The Laboratory of Exercise Physiology and Physical Performance (LEP3) was established within the Section of Endocrinology, Diabetes and Nutrition. The LEP3 is an 850 square foot exercise laboratory under the direction of Drs. Shalender Bhasin (Chief) and Thomas Storer (Director). The global mission of this state of the art clinical research laboratory is to assess muscle performance and physical function in states of health and disease.
STEROID HORMONE ASSAY LABORATORY
The Steroid Hormone Assay Laboratory (Shalender Bhasin, MD., Director) specializes in the measurements of sex steroid hormones and vitamin D analogs using liquid chromatography tandem mass spectrometry (LC-MS/MS). Anqi Zhang, Ph.D. has established new methods for the measurement of testosterone and estradio