Xiaofeng Lin, PhD

Lin_Xiaofeng

Assistant Professor of Dermatology

Administrative Office:

Boston University School of Medicine, Dept of Dermatology

609 Albany Street, J-608, Boston, MA 02118
Tel: 617-638-5500
Fax: 617-638-5515

Education

  1. Weifang Medical College, Weifang, Shandong Province, PR China – MD, Clinical Medicine (1998)
  2. University of Rhode Island, Kingston, RI – PhD, Biochemistry (2005)
  3. University of Rhode Island, Kingston, RI – Postdoctoral Fellow (2005-2008)
  4. Roger Williams Medical Center, Providence, RI – Postdoctoral Fellow (2008-2010)

Clinical Specialties and Research Interests

The Wound Healing Translational Research Laboratory

  • Stem Cells and Wound Healing

Summary

Tissue repair is critical to the survival of all living organisms. Chronic wounds such  as pressure, diabetic, and venous ulcers are difficult to heal. It has been hypothesized that stem cells may stimulate the healing of difficult-to-heal wounds. I am interested in probing the effects and mechanisms of bone marrow-derived adult stem cells in accelerating wound healing in mice and humans. An FDA-approved, prototypic living bilayered skin construct (BSC) has been used for non-healing wounds. I am interested in probing different priming conditions through a series of in vitro and in vivo experiments, including the epiboly assay and a mouse wound model, to see their effects on BSC gene expression and wound healing stimulation.

Selected Publications

  1. Falanga, V., Carson, P., Fiore, D., Lin, X., Yufit, T. Wound healing mouse model without contraction to study epidermal migration and mechanisms of action. Journal of Investigative Dermatology, Volume 133, Supplement 1, No.1506, May 2013.
  2. Luo, S., Yufit, T., Carson, P., Fiore, D., Falanga, J., Lin, X., Mamakos, L., and Falanga, V. Differential keratin expression during epiboly in a wound model of bioengineered skin and in human chronic wounds. (2011) Int. J. Low. Extrem. Wound. 10(3), 122-9.
  3. Iwamoto, S., Lin, X., Iwamoto, A., Yufit, T., Carson, P., Fiore, D., Korbrin, K., Morgan, J., Zak, I., Hammerman, S., Greer, D., and Falanga, V. GCSF-induced mobilization of bone marrow stem cells accelerates healing of experimental mouse wounds. Wound Repair and Regeneration. Volume 19, Issue 2, MS1.06, March-April 2011.
  4. Lin, X., Fiore, D., Lu, M., Yufit, T., Kwak, T., Carson, P., and Falanga, V. An in vitro priming strategy activates an established tissue engineering construct and leads to greater efficacy and a dramatic burst in levels of genes associated with epidermal growth and migration. Wound Repair and Regeneration. Volume 19, Issue 2, BRG.03, March-April 2011.