Xiaofeng Lin, PhD
Assistant Professor of Dermatology
Boston University School of Medicine
Boston University School of Medicine, Dept of Dermatology
609 Albany Street, J-608, Boston, MA 02118
|2005||PhD||University of Rhode Island, Kingston, RI|
|2005-2008||Postdoctoral Fellowship||University of Rhode Island, Kingston, RI|
|2008-2010||Postdoctoral Fellowship||Roger Williams Medical Center, Providence, RI|
Clinical Specialties and Research Interests
- Stem Cells and Wound Healing
Tissue repair is critical to the survival of all living organisms. Chronic wounds such as pressure, diabetic, and venous ulcers are difficult to heal. It has been hypothesized that stem cells may stimulate the healing of difficult-to-heal wounds. I am interested in probing the effects and mechanisms of bone marrow-derived adult stem cells in accelerating wound healing in mice and humans. An FDA-approved, prototypic living bilayered skin construct (BSC) has been used for non-healing wounds. I am interested in probing different priming conditions through a series of in vitro and in vivo experiments, including the epiboly assay and a mouse wound model, to see their effects on BSC gene expression and wound healing stimulation.
1. Falanga, V., Lin, X., Yufit, T., Sharova, TY., Sharov, A., Fiore, D., and Carson, P. Very small embryonic-like stem cells accelerate healing and differentiate into epidermal and endothelial cells. Volume 134, Supplement 1, No. 790, May 2014.
2. Iwamoto, S., Lin, X., Ramirez, R., Carson, P., Fiore, D., Goodrich, J., Yufit, T., and Falanga, V. Bone marrow cell mobilization by the systemic use of granulocyte colony-stimulating factor (GCSF) improves wound bed preparation. (2013) Int J Low Extrem Wounds. 12(4), 256-64
3. Falanga, V., Carson, P., Fiore, D., Lin, X., Yufit, T. Wound healing mouse model without contraction to study epidermal migration and mechanisms of action. Journal of Investigative Dermatology, Volume 133, Supplement 1, No.1506, May 2013.
4. Luo, S., Yufit, T., Carson, P., Fiore, D., Falanga, J., Lin, X., Mamakos, L., and Falanga, V. Differential keratin expression during epiboly in a wound model of bioengineered skin and in human chronic wounds. (2011) Int. J. Low. Extrem. Wound. 10(3), 122-9.
5. Iwamoto, S., Lin, X., Iwamoto, A., Yufit, T., Carson, P., Fiore, D., Korbrin, K., Morgan, J., Zak, I., Hammerman, S., Greer, D., and Falanga, V. GCSF-induced mobilization of bone marrow stem cells accelerates healing of experimental mouse wounds. Wound Repair and Regeneration. Volume 19, Issue 2, MS1.06, March-April 2011.
6. Lin, X., Fiore, D., Lu, M., Yufit, T., Kwak, T., Carson, P., and Falanga, V. An in vitro priming strategy activates an established tissue engineering construct and leads to greater efficacy and a dramatic burst in levels of genes associated with epidermal growth and migration. Wound Repair and Regeneration. Volume 19, Issue 2, BRG.03, March-April 2011.