Mei-Yu Hsu, MD, PhD
Boston University School of Medicine
609 Albany Street, J-203A
Boston, MA 02118
|1992||MD||Kaohsiung Medical University, Taiwan|
|1997||PhD||University of Pennsylvania, Philadelphia, PA|
|1997-1998||Post-doc fellowship||Wistar Institute, Philadelphia, PA|
|1998-2002||House Staff||Dept of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA|
|2002-2003||Fellowship||Dermatopathology, Dept of Dermatology, UT Southwestern Medical Center, Dallas, TX|
Clinical Specialties and Research Interests
- Laboratory of Dr. Mei-Yu Hsu
Dr. Mai-Yu Hsu received her MD summa cum laude from Kaohsiung Medical University in Taiwan and her PhD in Molecular Cell Biology under the mentorship of Dr. Meenhard Herlyn from the University of Pennsylvania, where she is the recipient of the Saul Winegrad Dissertation Award. She is a Diplomat of the American Board of Pathology in AP and CP and the American Board of Pathology and Dermatology in Dermatopathology. In addition to her clinical interest in dermatopathology, Dr. Hsu oversees an active NIH-funded research program, which revolves around the biological significance of morphogenic pathways, particularly bone morphogenetic proteins, in melanoma morphogenesis, heterogeneity, and homeostasis. Using expression analyses, molecular manipulation of target gene expression and functional assays in three-dimensional organotypic cultures in vitro as well as in animal modes in vivo, studies are underway to dissect the structural organization and functional significance of melanoma subpopulations.
1. Menke J, Hsu M-Y, Byrne KT, Lucas JA, Rabacal WA, Croker BP, Zong X-H, Stanley ER, Kelley VR. Sunlight triggers cutaneous lupus through a colony stimulating factor-1 (CSF-1) dependent mechanism in MRL-Faslpr mice. J Immunol 2008; 181: 7367-7379. (Cover illustration)
2. Laga AC, Lai C-Y, Zhan Q, Huang SJ, Velazquez EF, Yang Q, Hsu M-Y*, Murphy GF*. Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and Merkel cell biology. Am J Pathol 2010, 176:903-913.
3. McAllister JC, Zhan Q, Weishaupt C, Hsu M-Y, Murphy GF. The embryonic morphogen, nodal, is associated with channel-like structures in human malignant melanoma xenografts. J Cutan Pathol 2010, 37 S1:19-25.
4. Van Otterloo E, Li W, Bonde G, Day KM, Hsu M-Y, Cornell RA. Differentiation of Zebrafish melanophores depends on transcription factors AP2 alpha and Ap2 epsilon. PloS Genet 2010, 6(9). pii:e1001122.
5. De Luca A, Laumura L, Strizzi L, Roma C, Antonio AD, Margaryan N, Pirozzi G, Hsu M-Y, Botti G, Mari E, Hendrix MJC, Salomon DS, Normanno N. Expression and functional role of CRIPTO-1 in cutaneous melanoma. Br J Cancer 2011, 105:1030-1038.
6. Pinc A, Somasundaram R, Wagner C, Hormann M, Karanikas G, Jalili A, Bauer W, Brunner P, Grabmeier-Pfistershammer K, Gschaider M, Lai, C, Hsu M-Y, Herlyn M, Sting G, Wagner S. Targeting CD20 in melanoma patients at high risk of disease recurrence. Mol Ther 2012, 20:1056-1062.
7. Lai C-Y, Schwartz BE, Hsu M-Y*. CD133+ melanoma subpopulations contribute to perivascular niche morphogenesis and tumorigenicity through vasculogenic mimicry. Cancer Res 2012, 72(19):5111-5118.