Barbara A. Gilchrest, MD

Barbara Gilchrest

Professor & Chair-Emeritus,

Department of Dermatology

Editor in Chief, Journal of Investigative Dermatology

Clinic:

To Schedule An Appointment: 617-638-7420

Shapiro Ambulatory Care Center

725 Albany Street, Suite 8B, Boston, MA 02118
Fax: 617-638-7289

 

Administrative Office:

Boston University School of Medicine, Dept of Dermatology

609 Albany Street, Boston, MA 02118
Tel: 617-638-5500
Fax: 617-638-5515

Education

  1. BS (Mathematics) 1967, Massachusetts Institute of Technology, Cambridge MA
  1. MD 1971, Harvard Medical School, Boston MA
  1. 1971-73 Internal Medicine, Harvard Service, Boston City Hospital
  1. 1973-76 Resident, Department of Dermatology, Harvard Medical School, Boston MA
  1. 1976-77 Research Fellow in Dermatology, Harvard Medical School, Research Associate Department of Biology, Massachusetts Institute of Technology

Clinical Specialty and/or Research Interest

Clinical Dermatology

UV Effects on Skin, including prevention and treatment of skin cancer, melanogenesis, photoaging, cellular gerontology, and telomere biology

Summary

Barbara Gilchrest, MD is Professor and Chair-Emeritus of the Department of Dermatology at Boston University School of Medicine and Boston Medical Center (BMC). Dr. Gilchrest received her medical degree from Harvard Medical School and completed Residencies in Internal Medicine and Dermatology at Harvard-affiliated hospitals. She is Board Certified in Internal Medicine and Dermatology. Prior to her appointment as Chair of the Department of Dermatology, Dr. Gilchrest held academic appointments at Harvard Medical School and Tufts University School of Medicine. Dr. Gilchrest has clinical and laboratory-based research interests in skin aging and pigmentation and has published extensively based on her pioneering work in these fields. She is cited in the book, 100 Best Doctors in America, and is a member of the Institute of Medicine of the National Academics of Science.

Selected Publications

1. Yaar M, Arble BL, Stewart KB, Qureshi NH, Kowall NW, Gilchrest BA. p75NTR antagonistic cyclic peptide decreases the size of beta amyloid induced brain inflammation. Cell Mol Neurobiol 28:1027–1031, 2008.

2. Arad S, Zattra E, Hebert J, Epstein E, Goukassian D, Gilchrest BA. Topical pTT treatment reduces UV-induced BCC development in Ptch-1 +/- mice. Am J Pathol. 172: 1248-1255, 2008.

3. Eller MS, Liao X, Liu SY, , Hanna K, Backvall H, Opresko PL, Bohr VA, Gilchrest BA.  A role for WRN in telomere-based DNA damage responses.  Proc Natal Acad Sci (USA). 103:15073-8, 2006.

4. Park HY, Wu H, Kiloran C, Gilchrest BA.  The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-β on melanosomes.  J Cell Sci 117:3659-68, 2004.

5. Goukassian DA, Helms E,  van Steeg H, van Oostrom C, Bhawan J, Gilchrest BA.  Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.  Proc Natl Acad Sci (USA). 101:3933-3938, 2004.

6. Park HY, Perez JM, Laursen R, Gilchrest BA.  Protein kinase C-b activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain.  J Biol Chem 274:16470-16478, 1999.

7. Eller MS, Maeda T, Magnoni C, Atwal D, Gilchrest BA.  Enhancement of DNA repair in human skin cells by thymidine dinucleotides:  Evidence for a p53-mediated mammalian SOS response.  Proc Natl Acad Sci USA 94:12627-12632, 1997.