Ayman Grada, MD, MS
Postdoctoral Fellow in Cutaneous Wound Healing
Boston University School of Medicine, Dept of Dermatology
609 Albany St. J600-A, Boston, MA 02118
|2014 – Present||Postdoctoral Wound Fellow||Boston University School of Medicine, MA, USA|
|2012-2015||Dermatology Trainee||Boston University School of Medicine, MA, USA|
|2010-2012||Research Associate||Laboratory for Tissue Regeneration, Department of Chemical Engineering, Oklahoma State University, OK, USA|
|2010-2012||MS in Healthcare Administration||Oklahoma State University, Stillwater, OK, USA|
|2004-2005||Medical Internship||University of Tripoli, Libya|
|1997-2004||MD||University of Tripoli, Libya|
Clinical Specialties and Research Interests
- Medical Dermatology
- Chronic Wounds and Lymphedema
- Stem Cell Therapies
- Collective Cell Migration
- Transdermal Drug Delivery
- Heuristics in Clinical Decision-making
- Clinical Dermatology
- Pigmentation Disorders
- Wound Healing
- Bounded Rationality in Clinical Decision-making
- Translational Wound Research
- Topical Application of autologous bone marrow-derived mesenchymal stem cells to treat difficult-to-heal wounds. Randomized controlled trial.
- Collective cell migration of keratinocytes and fibroblasts in acute and chronic wounds.
- Exploring innovative cost-effective solutions to treat wounds in resource-limited settings such as war zones and areas of violent conflict that are taking place around the world.
- Drug Delivery
- Transdermal delivery of macromolecules using novel chemical penetration enhancers designed via in silico, non-linear QSPR modeling, utilizing genetic algorithms and artificial neural networks.
- Conduct Insulin in-vitro permeation experiments to validate the computational modeling of insulin permeation through the skin
- Conduct in-vivo animal trials to evaluate the efficacy of different chemical penetrating enhancers on the trans-dermal delivery of insulin analogue in rat models
- Systems Biology of Wound Healing
- Understanding the pathobiological mechanisms of wound repair and regeneration enables us to design better therapeutic models. Wound healing is a complex dynamical process that involves an interplay of several internal and external agents, with high degree of interdependence. I am particularly interested in applying network-based approach to study the biochemical interactions that influence wound healing. Moreover, recent advances in network science, machine learning, and computational modeling can be utilized to model and simulate collective cell migration, identify patterns in cellular behavior, and perhaps predict responses to perturbations. Such in-silico models can complement traditional experimental research and help in narrowing research questions.
- Grada A, Otero-Vinas M, Prieto-Castrillo F, Obagi Z, Falanga V. Research Techniques Made Simple: Analysis of Collective Cell Migration Using the Wound Healing Assay. Journal of Investigative Dermatology. 2017 Feb 28;137(2):e11-6.
- Grada A, and Phillips TJ. Lymphedema: A Review of Literature Part-1. Pathophysiology and Clinical Manifestations. J Am Acad Dermatol. In press.
- Grada A, and Phillips TJ. Lymphedema: A Review of Literature Part- 2. Diagnosis and Management. J Am Acad Dermatol. In press.
- Grada A, Falanga V. Cryofibrinogenemia-Induced Cutaneous Ulcers: A Review and Diagnostic Criteria. American Journal of Clinical Dermatology. 2016 Oct 12:1-8.
- Grada A, Falanga V. Novel Stem Cell Therapies for Applications to Wound Healing and Tissue Repair. Surgical technology international. 2016 Oct 6;29.
- Grada A, Weinbrecht K. Next-generation sequencing: methodology and application. Journal of Investigative Dermatology. 2013 Aug 31;133(8):1-4.
- Grada A, Falanga V. Comparative analysis of animal models of wound healing. J Invest Dermatol. June 2017