Boston University Medical Campus
Cellular and Molecular Hearing Research

Douglas A. Cotanche: Curriculum Vitae

Curriculum Vitae
Douglas A. Cotanche, PhD
8/6/2008

 

Academic Training:

1977	B.A. University of New Hampshire , Durham , NH , Zoology, Theatre
1983	Ph.D. University of North Carolina , Chapel Hill , NC , Anatomy

Postdoctoral Training:

1983-1985

University of Pennsylvania , Philadelphia , PA , Cell Biology

Academic Appointments:

1985-1987	Assistant Professor of Anatomy and Cell Biology, and Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, S.C.
1987-1993	Assistant Professor of Anatomy & Neurobiology, Boston University School of Medicine, Boston , MA
1993-1997	Associate Professor of Anatomy & Neurobiology, Boston University School of Medicine, Boston , MA
1998-2008	Associate Professor, Department of Otolaryngology and Communication Enhancement, Children’s Hospital;, Department of Otology & Laryngology, Harvard Medical School, Boston, MA
2003-present	Affiliated Faculty, Harvard-MIT Division of Health Sciences and Technology
2008-present	Associate Professor (pending), Department of Otolaryngology, Boston University School of Medicine, Boston , MA.

Hospital or Affiliated Institution Appointments:

1996-	Research Associate, Department of Otolaryngology, Children’s Hospital
1998-2006	Director of Research, Department of Otolaryngology, Children’s Hospital
1998-	Faculty Affiliate, Program in Neuroscience, Harvard Medical School
1998-	Faculty Affiliate, Developmental Disabilities Research Center , Dept. of Neurology, TCH Faculty Member, Speech and Hearing Biosciences and Technology Program Faculty Member, Hearing Research Center , Boston University
1999-	Founding Member, Harvard Medical School Center for Hereditary Deafness
2002-	Member, Harvard Center for Neurodegeneration and Repair
2003-	Affiliated Faculty, Harvard-MIT Division of Health Sciences and Technology

Honors:

1985	Grass Foundation Fellow, Marine Biological Laboratory, Woods Hole, MA.
1987	National Research Council Junior Investigator Award. Granted by the Committee on Hearing, Bioacoustics and Biomechanics (CHABA).
1989-1991	Candidate, Charles Judson Herrick Award for Outstanding Young Neuroanatomist, American Association of Anatomists.
1993	Proctor & Gamble Teaching Award for Excellence in Teaching in the Basic Sciences, Boston University Goldman School of Graduate Dentistry.
2007	Winner, Harvard Medical School Prize for Excellence in Teaching
2007	Finalist, Irving M. London Teaching Award, Harvard-MIT Division of Health Sciences and Technology

Licenses and Certification: none

Departmental and University Committees:

Boston University School of Medicine:

1990-1995	Academic Advisor to Medical Students
1991	New Faculty Search Committee, Department of Anatomy & Neurobiology
1991-1997	Co-Coordinator of BUSM Confocal Laser Scanning Microscope Core Facility
1993-1995	Steering Committee, Interdepartmental Neuroscience Program
1994-1997	Executive Committee- Molecular & Cellular Biology Program
1996-1997	Admissions Committee- Molecular & Cellular Biology Program
1996-1997	Advisory Committee, MD-PhD Program

Children’s Hospital, Harvard Medical School:

1998-2006	Pediatric Otolaryngology Fellowship Admissions Committee
1998-2008	Children’s Hospital Research Faculty Council
1999-2006	Department of Otolaryngology Research Committee (chair, 1999-2005)
1999-2001	Children’s Hospital Research Computing Steering Committee
2000-	Neurotologist Faculty Search Committee, Department of Otology & Laryngology
	Massachusetts Eye & Ear Infirmary, Harvard Medical School
2001-2007	Children’s Hospital IACUC Committee
2001-2007	Children’s Hospital Research Faculty Council Education Committee
2001-2007	Department of Otolaryngology IRB Review Committee
2002-2008	Children’s Hospital Surgical Research Committee
2004-present	HST MD Admissions Committee, Harvard-MIT Division of Health Sciences & Technology
2006-2007	Children’s Hospital NIH eSubmission Transition Team
2006-2007	Chair, Children’s Hospital Research Information Technology Executive Committee
2006-2007	Children’s Hospital Click Commerce Grant Management Software Implementation Steering Committee

Boston University School of Medicine:

2008 –

BUMC IACUC Committee

 

Teaching Experience and Responsibilities:

Harvard Medical School

2002-

HST 010 Human Functional Anatomy Lecturer, Lab Instructor Medical Students and Graduate Students in the HST Program (55) 20 hours per week for 3 month duration of the course

Boston University School of Medicine

1987-1997

Gross Anatomy for Medical Students Lecturer, Lab Instructor, Section Director- Thorax, Abdomen & Pelvis, 1990 Medical Students (160), Graduate Students (5) 25 hours per week for 3 month duration of the course

Goldman School of Graduate Dentistry ( Boston University )

1991-1997

Gross Anatomy for Dental Students Course Co-Director, Lecturer, Lab Instructor Dental Students (90) 35 hours per week for 3 month duration of the course

Harvard Medical School graduate medical course

1998-2000	Basic Science Course for Residents, Department of Otolaryngology, Massachusetts Eye & Ear Infirmary. Otolaryngology Residents and Research Fellows (10) One lecture on Embryology of the Ear.
1998-2001	Research Seminar Series, Department of Otolaryngology, Children’s Hospital Series Coordinator Faculty, Staff, Fellows, Residents (20-30) Monthly seminar series on research projects ongoing in the Department.
1999-	Children’s Hospital & Boston Center for Deaf and Hard of Hearing Children Fall Seminar: Cochlear Implants 101 Just the Facts Speaker on Cochlear Anatomy with respect to Implants Audiologists, Speech Pathologists, Teachers, Caregivers in the Greater Boston Area (80)
2000-	HST 730 Molecular Biology of the Auditory System. Harvard Medical School Graduate students in the Speech & Hearing Sciences program (10) One lecture on hair cell regeneration.

Graduate Program, Boston University School of Medicine

1988-1989	Cell and Developmental Biology, Department of Anatomy & Neurobiology Course Co-Director Graduate Students in Anatomy & Neurobiology (10-15) 10 hours per week for one semester each year
1989-1997	Neural Development & Plasticity, Department of Anatomy & Neurobiology Lecturer, Course Coordinator- 1994 Graduate Students and Postdocs in Anatomy & Neurobiology (10-15)
1994-1997	Graduate Seminar in Ethics in Scientific Research, Department of Anatomy & Neurobiology Course Co-Coordinator Graduate Students and Postdocs in Anatomy & Neurobiology (10-15) 10 hours per week for two semesters each year
1990-1997	Cell Biology, Division of Graduate Medical Sciences Lecturer Graduate students from all departments (30-70) Two lectures per year plus exam grading
1992-1997	Confocal Microscope Training Course, Division of Graduate Medical Sciences Course Co-Coordinator, Lecturer Faculty, Staff, and graduate students at BUSM (30-70) One week of lectures plus hands-on training on the confocal
1997	Molecular Biology for Neuroscientists, Department of Anatomy & Neurobiology Course Co-Coordinator Faculty, Staff, Postdocs, and Graduate Students (20) 10 hours per week for one semester

Major Administrative Responsibilities: none

 

Other Professional Activities:

Professional Societies: Memberships, Offices, and Committee Assignments

1982- Association for Research in Otolaryngology

1983- American Society for Cell Biology

1983- American Association for the Advancement of Science

1983- Society for Neuroscience

2000- American Society for Matrix Biology

2004- International Society for Stem Cell Research

Editorial Boards:

1989- Hearing Research

1995- Audiology and Neuro-Otology

2005 Hearing Research, Section Editor

 

Major Committee Assignments:

Federal Government

1995-1996 Scientific Panel, NIH National Strategic Research Plan, Hearing and Hearing Impairment Section, NIDCD

Private/Foundation

1985-1998 Chairman, Poster Session Committee, ARO Midwinter Meeting

1990-1993 Advisory Committee of Young Anatomists, American Association of Anatomists

1991-1993 Chairman, Jan Langman Graduate Student Awards Presentations, American Association of Anatomists

1992 Poster Session Organizer, 1 st Molecular Biology of Hearing and Deafness Conference

1994 Consultant, Genetics Institute, Cambridge , MA

1994 Organizing Committee and Invited Speaker, Deafness Research Foundation Conference on the Mechanisms of Sensory Regeneration, Charlottesville , VA.

1996 Book Reviewer, Ear and Hearing

1996 Nominating Committee, Association for Research in Otolaryngology

1998-2001 Scientific Review Board, Central Institute for the Deaf, St. Louis , MO

1999-2002 Secretary/Treasurer, Association for Research in Otolaryngology

2000-2001 Deafness Research Foundation Research Task Force

2000- Chair, Graduate Student/Postdoc Travel Awards Committee, ARO

2001-2003 Advisory Board, Department of Defense Spatial Orientation Center , San Diego , CA.2001-

2001-2004 Chairman, Grants Management Committee, Deafness Research Foundation

2004 Council of Scientific Trustees, Deafness Research Foundation

2004-2007 Council of the Association for Research in Otolaryngology

2005 ARO Midwinter Meeting Site Selection Committee (Chair)

2007 Nominating Committee, Association for Research in Otolaryngology

Study Sections

National Science Foundation

1985-1987 Ad hoc Reviewer, Developmental Neurosciences Panel- NSF

1989-1990 Ad hoc Grant Reviewer, Neuroscience Program- NSF

1992-1995 Ad hoc Grant Reviewer, Sensory Systems Program- NSF

2002 Grant Reviewer, Developmental Neurosciences Panel- NSF

2002 Grant Reviewer, Sensory Systems Panel- NSF

National Institutes of Health

1985 Outside Reviewer, Hearing Research Study Section- NIH DRG

1992 Ad hoc Member, Sensory Disorders & Language Study Section, NIH

1993 Ad hoc Member, Sensory Disorders and Language Study Section, NIH/DRG

1994 Outside Reviewer, Hearing Reseach Study Section- NIH DRG

1994 Ad hoc Member, Hearing Research Study Section- NIH/DRG

1994 Outside Reviewer of RTC Grants, NIDCD Scientific Review Board

1996-1997 Ad hoc Member, Communication Disorders Review Committee, NIDCD

1997-1999 Member, Special Emphasis Panel on Small Grants, NIDCD

1998 Outside Reviewer, Molecular, Cell and Dev. Neurosciences Study Section, NIH

2002 Ad hoc Member, IFCN-6 Study Section, NIH/CSR

2002 Grant Reviewer, NIH/NIDCD Communication Disorders Review Committee

2007 Ad hoc Member, NHI/NIDCD Hearing and Balance Review Panel

2004 Grant Reviewer, NIDCD Small Grants Program Study Section

2007 Reviewer, NIDCD Special Emphasis Panel on NIH Loan Repayment Applications

2007 Ad hoc Member, NIH/CSR AUD Study Section

2007 Ad hoc Member, AUD Study Section, NIH/CSR

2008 Ad hoc Member, NIH/CSR AUD Study Section

2008 Ad hoc Member, NIH/NIDCD P50 Study Section

2008 Ad hoc Member, NIH/NIDCD P30 Study Section

2008 Ad hoc Member, NIH/NIGMS SCORE Grant Study Section

2008 Ad hoc Member, NIH/CSR IFCN-F Study Section

Foundation

1986-1988 Reviewer of Abstracts submitted for ARO Midwinter Meeting

1988 Reviewer, Innovative Research Fund, N.C. Technological Development Authority

1991-1993 Grant Reviewer, VA Medical Research Service- Neurobiology Merit Review Board

1993-1996 Grant Reviewer for the Neurosciences Program, Wellcome Trust, London , UK

1993-1994 Scientific Review Committee, National Organization for Hearing Research

1994 Grant Reviewer , Virginia Sea Grant College Program

1998 Grant Reviewer, Alzheimer’s Disease Research Center, University of Washington

1998-1999 Outside Thesis Reviewer, University of Queensland , Australia

1998-1999 Grant Reviewer, Neurosciences Programme, Wellcome Trust, London , UK

2003 Grant Reviewer, AAO-HNS CORE Study Section

2003 Grant Reviewer, Royal National Institute for Deaf People (RNID), London , UK

2006 Outside Thesis Reviewer, University of New South Wales , Australia

2008 Grant Reviewer, Medical Research Council, London , UK

State: none

 

Current Other Support:

2006-09 NIH/NIDCD RO1, Douglas A. Cotanche, P.I.; Cell Form and Gene Expression in Hair Cell Regeneration ($637,500 over 3 years, 12/06-11/09, 50% salary support).

2006-09 NIH/NIDCD F32 Christina L. Kaiser, Ph.D., P.I., Douglas A. Cotanche, Mentor; Inhibition of Gentamicin-induced Cochlear Hair Cell Death ($138,768 over 3 years).

2007-10 NIH/NIDCD F31 Nathaniel J. Spencer, P.I., Douglas A. Cotanche, Co-Mentor; Engineering a Basement Membrane to Prolong Chick Hair Cell Viability In Vitro ($60,000 over 3 years).

Past Other Support:

1982 UNC Junior Faculty Development Award, Kathleen K. Sulik, P.I., Douglas A. Cotanche, Co-P.I.,; Analysis of the Developing Avian Tegmentum Vasculosum

1984 NRSA Postdoctoral Award, Douglas A. Cotanche, P.I., Lewis G. Tilney, Sponsor; The Organization and Function of Actin in Stereocilia

1985 Medical University of South Carolina Intramural Research Grant, Douglas A. Cotanche, P.I.; Developmental Control of Hair Cell Morphology

1986 Deafness Research Foundation New Investigator Award, Douglas A. Cotanche, P.I.; Hair Cell Response to Acoustic Trauma,

1987 BUSM Biomedical Research Support Grant, Douglas A. Cotanche, P.I.; Regeneration in the Cochlear Sensory Epithelium

1988 NIH/NIDCD FIRST Award, Douglas A. Cotanche, P.I.; Regulation of Hair Cell Development and Regeneration

1989 Deafness Research Foundation, Douglas A. Cotanche, P.I.; Contractile Proteins in the Hyaline Cells of the Chick Cochlea

1990 Whitaker Health Sciences Fund BUMC-MIT Collaborative Research Grant, Douglas A. Cotanche and Thomas F. Weiss (MIT), Co-P.I.’s; Video-Enhanced, Computer-Processed Images of the Unfixed Tectorial Membrane

1992 NIH/NIDCD RO1 New Submission, Douglas A. Cotanche, P.I.; Cell Form and Gene Expression in Hair Cell Regeneration

1995 National Organization for Hearing Research, Douglas A. Cotanche, P.I.; Molecular Identification of Potential Stimulators of Hair Cell Regeneration

2001 NIH/NIDCD RO1 Competing Renewal, Douglas A. Cotanche, P.I.; Cell Form and Gene Expression in Hair Cell Regeneration ($677,533 over 5 years, 36% salary support).

1996 American Hearing Research Foundation, Douglas A. Cotanche, P.I.; Regeneration of the Avian Tectorial Membrane

1996 National Organization for Hearing Research, Douglas A. Cotanche, P.I.; The Role of FGF and Retinoic Acid in Hair Cell Regeneration

1997 National Organization for Hearing Research, Douglas A. Cotanche, P.I.; Regulation and Expression of Genes Involved in Hair Cell Regeneration

1998 National Organization for Hearing Research, Douglas A. Cotanche, P.I.; Regulation and Enhancement of Hair Cell Regeneration

1998 NIH/NIDCD KO8, David Roberson, P.I.; Douglas A. Cotanche, Mentor ; Genetic Mechanisms of Direct Transdifferentiation.

2000 National Organization for Hearing Research, Petula A. Coutinho, P.I., Douglas A. Cotanche, co-P.I.; Molecular Cloning and Expression of Connexin Genes during Development in the Avian Inner

2000 NIH/NIDCD RO1, Claude Lechene, P.I.; Douglas A. Cotanche, Co-Investigator; Spatial Dynamics of Protein Turnover in the Cochlea ($77,350 for 3 years, 12% salary support).

2001 Deafness Research Foundation, Petula A. Coutinho, P.I., Douglas A. Cotanche, co-P.I.; How Does Gap Junction Communication Affect Structure and Function in the Normal and Drug Damaged Avian Cochlea?

2001 Deafness Research Foundation, Douglas A. Cotanche, P.I. The Role of Apoptosis in Regulating Hair Cell Death and Supporting Cell Proliferation.

2001 National Organization for Hearing Research, Douglas A. Cotanche, P.I., Matthew W. Kelley, Co-P.I. Development of Stem Cell Populations for Utilization in Cochlear Transplantation ($283,980 over 3 years, 25% salary support).

2002 NIH/NIDCD F32 Mark A. Parker, Ph.D., P.I., Douglas A. Cotanche, Mentor; Therapeutic Effects of Stem Cells on Hearing Loss ($128,724 over 3 years).

2002 NIH/NIDCD F32 Jonathan I. Matsui, Ph.D., P.I., Douglas A. Cotanche, Co-Mentor; Genetic Analysis of Usher Syndrome in Zebrafish ($129, 784 over 3 years).

2001 NIH/NIDCD RO1, Douglas A. Cotanche, P.I.; Cell Form and Gene Expression in Hair Cell Regeneration ($637,500 over 5 years, 9/01-8/06, 50% salary support).

2004 Caroline Bass Fund, Douglas A. Cotanche, PI. Genomics of Stem Cells in the Cochlea ($100,000 for 2 years).

2002 Anonymous Philanthropic Donation, Douglas A. Cotanche, P.I.; Development of Stem Cells for Utilization in Cochlear Transplantation ($100,000 over 5 years).

2005 Patterson Trust Award, Douglas A. Cotanche, Ph.D., P.I.; Functional Analysis of Stem Cell Transplantation in the Mammalian Cochlea ($50,000 for 2 years)

2005 Kramer/Dosberg Fund Grant, Douglas A. Cotanche, P.I.; Functional Analysis of Stem Cell Transplantation in the Mammalian Cochlea ($50,000 for 2 years)

2006 National Organization for Hearing Research, Wen-Hann Tan, M.D., P.I., Douglas A. Cotanche, co-P.I.; The Microenvironment in Neural Stem Cell Development ($20,000 for 1 year).

2006 American Hearing Research Foundation, Jonathan I. Matsui, Ph.D., P.I., Douglas A. Cotanche, co-P.I.; Characterization of the Sensory Hair Cells and Supporting Cells of Zebrafish Mutants: marginal zone deficient and round eye ($20,000 for 1 year).

2006 Hood Foundation, Mark A. Parker, Ph.D., P.I., Douglas A. Cotanche, Mentor; Functional Analysis of Stem Cell Transplantation in the Mammalian Cochlea ($75,000 for 2 years)

Training Grants and Other Collaborative Research Projects

2001-06 NIH/NIDCD RO1 David Mountain , Ph.D., P.I., Department of Biomedical Engineering, Boston University . EarLab: A Virtual Hearing Laboratory. October 1, 2001- September 30, 2006. I serve as a consultant/collaborator on this project.

2006-11 NIH/NICHD P30 Core Grant, Michael Greenberg, PhD., P.I. Developmental Disabilities Research Center , Children’s Hospital. August 1, 2006- July 31, 2011. I serve as a Research Investigator on this project.

2002-07 NIH/NIDCD T32 Training Grant, Lou Braida, P.I., Massachusetts Institute of Technology. Training for Speech and Hearing Sciences. July 1, 2002- June 30, 2007. I serve as a member of the teaching faculty.

2002-07 NIH/NIDCD T32 Training Grant, Joseph Nadol, M.D., P.I. Research Training in Otolaryngology. July 1, 2002- June 30, 2007. I serve as a member of the teaching faculty.

2000-08 NIH/NIBIB P41 National Resource for Imaging Mass Spectrometry, Claude Lechene, MD, PI. September 1, 2000- August 31, 2008. I serve as a collaborator on this project.

2005- NIH/NIDCD P30 Hearing Research Center Core Grant, Department of Biomedical Engineering, Boston University , Steven H. Colburn, PhD, PI. I serve as a Key Personnel Researcher on the Center Grant.

Invited Lectures and Presentations

1987 Invited Seminar Speaker, BU Small Hearing Group Meeting, Department of Biomedical Engineering, Boston University , Boston , MA . Regulation of Hair Cell Development and Regeneration.

1988 Invited Seminar Speaker, Eaton-Peabody Laboratory, Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston , MA . Regulation of Hair Cell Development and Regeneration.

Invited Participant, Mechanics of Hearing 1988, a NATO Advanced Research Workshop, University of Keele , Staffordshire , UK

Invited Seminar Speaker, MRC Neurophysiology Group, University of Sussex , Brighton , U.K. Sensory Cell Regeneration in the Avian Cochlea.

Invited Seminar Speaker, Department of Physiology, The Medical School , University of Bristol , Bristol , U.K. Sensory Cell Regeneration in the Avian Cochlea.

Invited Seminar Speaker, BU Small Hearing Group Meeting, Department of Biomedical Engineering, Boston University , Boston , MA . Structure of the Avian Tectorial Membrane: Possibilities for a Bimodal Function.

1989 Invited Seminar Speaker, Department of Cell Biology and Anatomy, School of Medicine , University of North Carolina at Chapel Hill . Regulation of Stereocilia Growth in Developing and Regenerating Cochlear Hair Cells.

Invited Seminar Speaker, The Hair Cell Group, School of Medicine , University of North Carolina at Chapel Hill . Speculations on the Role of the Tectorial Membrane and Hyaline Cells in Basilar Membrane Mechanics.

Invited Seminar Speaker, Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston , MA . Regulation of Stereocilia Growth in Developing and Regenerating Cochlear Hair Cells.

Invited Seminar Speaker, Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston , MA . Speculations on the Role of the Tectorial Membrane and Hyaline Cells in Basilar Membrane Mechanics.

Invited Symposium Speaker, Symposium on Regeneration of Hair Cells Following Ototoxic Drugs and Noise Exposure, American Speech-Language-Hearing Association (ASHA) Convention, St. Louis , MO. Regeneration of Hair Cells Following Ototoxic Drugs and Noise Exposure.

Invited Seminar Speaker, Department of Otolaryngology, University of Washington , Seattle , WA . Common Mechanisms in the Development and Regeneration of Hair Cells in the Chick Cochlea.

1990 Invited Seminar Speaker, Department of Otolaryngology, The Children’s Hospital, Harvard Medical School , Boston , MA . Stereocilia-Tectorial Membrane Interactions During Development, Noise Damage and Regeneration.

Invited Symposium Speaker, Ciba Foundation Symposium on Regeneration of Sensory Receptor Cells in Vertebrates, The Ciba Foundation, London , UK . Structural reorganization of hair cells and supporting cells during noise damage, recovery, and regeneration in the chick cochlea.

Invited Seminar Speaker, Department of Otolaryngology, University of Washington , Seattle , WA . Contractile Proteins in the Hyaline Cells of the Chick Cochlea.

Invited Seminar Speaker, Tectorial Membrane-Stereocilia Interactions During Cochlear Development and Regeneration” Oct. 5, 1990. Department of Pathology, Boston University School of Medicine, Boston , MA .

Invited Seminar Speaker, Whitaker Health Sciences Fund Faculty Research Presentation Meeting, Massachusetts Institute of Technology, Cambridge , MA . Video-Enhanced, Computer-Processed Images of the Unfixed Tectorial Membrane.

1991 Invited Seminar Speaker, Central Institute for the Deaf, St. Louis , MO. Development and Regeneration of Hair Cells and the Tectorial Membrane in the Chick Cochlea.

Invited Participant, First Conference on Biological Replacement in Sensory Systems, Central Institute for the Deaf, St. Louis , MO.

Invited Seminar Speaker, Kresge Hearing Research Institute, University of Michigan , Ann Arbor , MI. Hair Cell and Tectorial Membrane Regeneration in the Chick Cochlea.

Department of Otolaryngology, University of Washington , Seattle , WA . Ear Stuff.

Invited Seminar Speaker, Department of Otolaryngology, University of Rochester School of Medicine , Rochester , N.Y. Birds Do It: Hair Cell Regeneration in the Chicken Cochlea.

Invited Seminar Speaker, Department of Biomedical Engineering, Boston University , Boston , MA . Birds Do It: Hair Cell Regeneration in the Chicken Cochlea.

Invited Seminar Speaker, Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston , MA . Birds Do It: Hair Cell Regeneration in the Chick Cochlea.

1992 Invited Seminar Speaker, Department of Otolaryngology, University of Kansas Medical Center, Kansas City , KS . Birds Do It: Hair Cell Regeneration in the Chick Cochlea.

Invited Symposium Speaker, Symposium on Auditory Hair Cells and Regeneration, American Speech-Language-Hearing Association (ASHA) Convention, San Antonio , TX . Cell cycle events in hair cell regeneration.

Invited Seminar Speaker, Genetics Institute, Cambridge , MA . Cell Cycle Events During Cochlear Hair Cell Regeneration.

1993 Invited Seminar Speaker, Department of Anatomy & Cell Biology, Tufts University , Boston , MA . Timing of S Phase and Patterns of Cell Proliferation During Hair Cell Regeneration.

Invited Seminar Speaker, Department of Anatomy & Neurobiology , Washington University School of Medicine , St. Louis . MO. Regeneration in the Chick Cochlea.

Invited Symposium Speaker, Workshop on the Effect of Noise on Birds, Hubbs-Sea World Research Institute, San Diego , CA. Noise-induced damage in the avian ear.

Invited Symposium Speaker, Symposium on Computational and Structural Biology: The Anatomy of the 21st Century, Joint Meeting of the American Association of Anatomists and Japanese Association of Anatomists. Confocal microscopic imaging of intracellular organization from whole mount tissues.

Invited Symposium Speaker, Hearing Research Trust Workshop: Repair and Regeneration in the Inner Ear, Wye College , Wye , Kent , UK . Early events in cell damage and progenitor stimulation during noise induced hair cell regeneration in the chick cochlea.

Invited Seminar Speaker, House Ear Institute, Los Angeles , CA. Hair Cell Regeneration in the Cochlea.

1994 Invited Seminar Speaker, Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia , PA. Hair Cell Regeneration in the Chick Cochlea.

Invited Seminar Speaker, Baule Colloquium Series of the Institute for Sensory Research, Syracuse University , Syracuse , NY . Regulation of Hair Cell Regeneration in the Cochlea.

Invited Seminar Speaker, The Shriver Mental Retardation Research Center , Waltham , MA . Hair Cell Regeneration in the Inner Ear.

Invited Symposium Speaker, Wellcome Trust Meeting on Human Olfaction and Audition: Parallels and Emerging Research Strategies, London , UK . Hair Cell Regeneration in the Cochlea: Possibilities for Therapeutic Use.

Invited Symposium Speaker, Deafness Research Foundation Conference on the Mechanisms of Sensory Regeneration, Charlottesville , VA. Regeneration in the Avian Cochlea.

1995 Invited Seminar Speaker, Hearing Research Group, Department of Biomedical Engineering, Boston University , Boston , MA . Interactions between cytoskeletal proteins and the extracelluar matrix in hair cells and supporting cells of the chick cochlea.

Invited Seminar Speaker, Department of Zoology, University of Maryland , College Park , MD. Hair Cell Regeneration in the Inner Ear.

Invited Symposium Speaker, “Frontiers in Hearing Research”, Opening Ceremony and Symposium for the Virginia Merrill Bloedel Hearing Research Center, School of Medicine, University of Washington, Seattle, WA. Hair cell regeneration in the avian cochlea.

Invited Seminar Speaker, R.L. Smith Mental Retardation and Human Development Research Center , University of Kansas Medical Center, Kansas City , KS . Hair Cell Regeneration in the Inner Ear.

Invited Seminar Speaker, Department of Biology, Boston College , Chestnut Hill , MA . Hair cell regeneration in the avian cochlea.

Invited Seminar Speaker, R.S. Dow Neurological Sciences Institute, Portland , OR . The Role of Growth Factors and Extracellular Matrix Proteins in Hair Cell Regeneration.

1996 Invited Seminar Speaker, Grand Rounds, Department of Otolaryngology- Head and Neck Surgery, Boston University Medical Center , Boston , MA . Hair Cell Regeneration.

(This was the year my twin daughters were born. I didn’t do a lot of traveling that year)

1997 Invited Seminar Speaker, Ontogeny, Inc., Cambridge , MA . The Role of Growth Factors in Regulating Hair Cell Regeneration.

Invited Seminar Speaker, Kresge Hearing Research Institute, University of Michigan , Ann Arbor , MI . The Role of Growth Factors in Regulating Hair Cell Regeneration.

Invited Seminar Speaker, Department of Otolaryngology and Communication Disorders, Children’s Hospital, Boston , MA . The Role of Growth Factors in Regulating Hair Cell Regeneration.

Invited Seminar Speaker, Department of Anatomy and Neurobiology, Boston University Medical Center , Boston , MA . Loss and Recovery of Efferent Innervation to the Hair Cells in the Regenerating Chick Cochlea.

Invited Seminar Speaker, League for the Hard of Hearing, New York , NY . Hair Cell Regeneration : The Reality and The Possibilities.

1998 Invited Symposium Speaker, House Ear Institute Inaugural Symposium on Cell and Molecular Biology of the Ear, Pasadena , CA . Loss and Regeneration of Cochlear Hair Cell Innervation Following Sound and Drug Damage.

Invited Symposium Speaker, Harvard School of Public Health Department of Environmental Health Symposium on Hearing Impairment: Causes, Prevention, New Treatment Technologies, and Access to Prevention and Technologies. New Technologies for Treatment of Hearing Loss.

Invited Seminar Speaker, Eaton-Peabody Laboratory, Mass Eye & Ear Infirmary, Boston , MA Regeneration of Cochlear Efferent Nerve Terminals After Sound Damage and Gentamicin Treatment.

Invited Symposium Speaker, 5 th Research Symposium, SHHH National Convention, Boston , MA . Can Hair Cells be Made to Regrow After Cochlear Damage?

Invited Seminar Speaker, Diacrin, Inc. Biotechnology Company, Cochlear Hair Cell Regeneration

Invited Symposium Speaker, Symposium on Neuroplasticity, American Speech-Language-Hearing Association (ASHA) 1998 Convention, San Antonio , TX . Hair Cell Regeneration: Theoretical and Practical Implications.

1999 Invited Symposium Speaker, ARO Educational Symposium on Anatomical Methods for Research in Otolaryngology. St. Petersburg Beach , FL. Confocal Microscopy.

Invited Symposium Speaker, Seminar Series on Hearing for the Hard-of-Hearing and Deaf Individuals, their Family Members, and Hearing Health Professionals. Sponsored by Oregon Hearing Research Center and OHSU, Portland Oregon . Inner Ear Cell Regeneration: Future Potential for Treatment of Hearing Loss.

Invited Graduation Speaker, Graduation Ceremonies for the Department of Otolaryngology- Head & Neck Surgery, Henry Ford Hospital , Detroit , MI . Cochlear Hair Cell Regeneration: Future Potential for Treatment of Hearing Loss.

Invited Speaker, Fundraising Event for the Deafness Research Foundation in support of the National Campaign for Hearing Health, The Yale Club, New York , NY . Hair Cell Regeneration in the Cochlea and its Potential as a Treatment for Human Deafness.

2000 Invited Seminar Speaker, Molecular Mechanisms of Hearing and Balance Seminar Series, Harvard Medical School Center for Hereditary Deafness. Cell Death and Proliferation in Regeneration.

Co-Organizer and Speaker, Symposium on Biotechnology and the Cochlea, Alexander Graham Bell Association Annual Convention, Philadelphia , PA July, 2000. Hair Cell Regeneration and the Development of a Biological Cochlear Implant.

Invited Speaker, CORLAS Meeting, Washington , DC August 2000. Aminoglycoside treatment alters TIAR expression in apoptotic hair cells.

Invited Speaker, Minuteman Cochlear Implant Club, Norwood , MA November, 2000. The Genetics of Hearing Loss: What We Know and Where We’re Headed.

2001 Invited Speaker, SHHH-NH, Manchester , NH January, 2001. The Genetics of Hearing Loss: What We Know and Where We’re Headed.

Invited Seminar Speaker, University of Iowa Otolaryngology Research Group, Iowa City IA March 19, 2001. Cell Death and Proliferation in Regeneration.

Invited Seminar Speaker, University of Iowa Department of Otolaryngology Grand Rounds, Iowa City IA March 20, 2001. Hair Cell Regeneration in the Cochlea and Its Potential as a Treatment for Human Deafness.

Invited Symposium Speaker, Conference on New Frontiers in the Amelioration of Hearing Loss, Central Institute for the Deaf, St. Louis , MO. March 22-25, 2001. Activating Influences on Supporting Cell Proliferation in the Regenerating Avian Cochlea.

2002 Invited Seminar Speaker, Children’s Hospital at Lexington , Audiology Department, Lexington , MA , February 26, 2002. Regeneration in the Avian Cochlea: Potential for Human Therapy?

Invited Seminar Speaker, University of Kansas Mecical Center , Department of Otolaryngology, Kansas City KS , July 11, 2002. Hair Cell Regeneration- A Tightly Coupled Dance of Death and Proliferation.

Invited Seminar Speaker, Long Island Chapter of HearUS, Wantaugh, LI. July 17, 2002. Regeneration in the Avian Cochlea: Potential for Human Therapy?

Invited Seminar Speaker, Southwestern Connecticut Chapter of Self Help for Hard of Hearing People (SHHH), Westport , CT , November 16, 2002. Hair Cell Regrowth
in the Cochlea.

2003 Invited Seminar Speaker, Massachusetts Eye & Ear Infirmary, Department of Otolaryngology, Boston , MA , Jan. 10, 2003. Hair Cell Regeneration- A Tightly Coupled Dance of Death and Proliferation.

Invited Seminar Speaker, Children’s Hospital-Boston, Department of Nephrology, Boston , MA , Jan. 30, 2003. Hair Cell Regeneration- A Tightly Coupled Dance of Death and Proliferation.

Invited Seminar Speaker, University of Michigan , Department of Otolaryngology, Ann Arbor , MI , April 9, 2003. Hair Cell Regeneration in the Avian Cochlea: Progress and Potential for Human Therapy.

Invited Seminar Speaker, Cochlear CONNection, the Connecticut Chapter of CIAI, New Haven , CT , May 21, 2003. Hair Cell Regeneration in the Cochlea: Potential for Human Therapy?

Invited Symposium Speaker, Northeast Cochlear Implant Convention, Sturbridge , MA , July 12, 2003. Hair Cell Regeneration in the Cochlea: Potential for Human Therapy?

2004 Invited Symposium Speaker, AG Bell Summit on Deafness, Washington , DC , February 27, 2004. Hair Cell Regeneration and Repair.

Invited Symposium Speaker, HearUS Long Island and DRF Conference on the Future of Hearing Impaired Children, Manhassett, NY, March 13, 2004. The Future of Hair Cell Regeneration.

Invited Symposium Speaker, Southern New England Junior Science and Humanities Symposium, HMS March 26, 2004. How the Ear Works and How Science can Help Treat Deafness.

Invited Seminar Speaker, Molecular Mechanisms of Hearing and Deafness Seminar Series, Harvard Medical School April 7, 2004. On Death and Dying: Hair Cell Apoptosis in the Avian Cochlea.

Invited Teleconference Speaker, ASHA Telephone Seminar, Harrisonburg , VA. July, 2004. Hair Cell Regeneration in the Inner Ear.

Invited Symposium Speaker, Audiology Keynote Symposium, 2004 ASHA Convention, Philadelphia , PA. November, 2004. Rescue, Repair and Regeneration in the Inner Ear.

2005 Invited Seminar Speaker, Department of Neuroscience, University of Connecticut Health Center, Farmington , CT , January 18, 2005. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Symposium Speaker, 2005 Speech & Hearing Association of Alabama Annual Meeting, Opelika , AL . March 4, 2005. Hair Cell Regeneration and Cochlear Repair.

Featured Speaker, Connecticut Chapter of the Alexander Graham Bell Association for the Deaf and Hard of Hearing Spring Conference, Farmington , CT. May 6-7, 2005. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Short Course Presenter, BCDC Next Steps… 2005 Conference, Boxborough , MA . 05/05/05. Biomedical Advances: Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Speaker, Advanced Fetal Care Center Research Conference, Boston , MA . 9/27/05 Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Speaker, Children’s Hospital Division of Neuroscience Lab Talks, 10/05/05. Death Becomes Her: The Apoptotic Cascade Regulates Hair Cell Death Following Aminoglycoside Treatment.

Invited Speaker, CNSR Conference, Mass General Hospital , Boston , MA . 10/11/05. Neural Stem Cell Transplantation in the Cochlea.

Invited Speaker, Children’s Hospital Stem Cell Program Meeting, Boston , MA . 11/04/05. Stem Cell Transplantation in the Mammalian Cochlea.

2006 Invited Translational Research Speaker, American Audiology Society, Scottsdale , AZ. 03/06/06. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Speaker, Symposium on Multi-Isotope Imaging Mass Spectrometry (MIMS) Applications to Biology, Harvard Medical School , Boston , MA . 06/22/06.

Invited Symposium Speaker, New Mexico Speech, Language, Hearing Association Annual Convention. Albuqueque , NM . 10/27/06. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

2007 Invited Symposium Speaker, 2007 Speech & Hearing Association of Alabama Annual Meeting, Mobile , AL. 03/03/07. Hair Cell Regeneration, Gene Therapy, and Stem Cell Transplantation in the Cochlea .

Invited Seminar Speaker, Department of Biology, Lehigh University , Bethlehem , PA. 04/05/07. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Seminar Speaker, Department of Otolaryngology, Wayne State University Medical School , Detroit , MI . 05/15/07. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Seminar Speaker, Audiology Lecture Series, Massachusetts Eye & Ear Infirmary, Boston , MA . 06/20/07. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Seminar Speaker, Neurology Grand Rounds, Tufts University School of Medicine, Boston , MA . 09/20/07. Can You Hear Me Now? Repairing the Damaged Inner Ear.

Invited Symposium Speaker, National Center for Rehabilitative Auditory Research Conference on “Hearing Therapies for the Future”. 09/27-28/07. Overview of Repair in Noise-Induced Hearing Loss.

Invited Seminar Speaker, University of Michigan , Department of Otolaryngology, Ann Arbor , MI, 10/17/07. Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

Invited Symposium Speaker, American Speech-Language-Hearing Association 17 th Annual Research Symposium on “Genetic and Biological Pathways Underpinning Communication Disorders Across the Lifespan”. Boston , MA 11/17/07. Genetic and pharmacological intervention for treatment/prevention of hearing loss.

Invited Seminar Speaker, Department of Otolaryngology, Head and Neck Surgery, Boston Medical Center , Boston , MA . 12/12/07. Can You Hear Me Now? Hair Cell Regeneration and Stem Cell Transplantation in the Cochlea.

2008 Invited Symposium Speaker, Deafness Research Foundation Conference on Cell Replacement in the Inner Ear. 6/13/08. Auditory Regeneration.

Bibliography

Original, peer reviewed articles:

1. Cotanche, DA, Sulik, KK. Scanning electron microscopy of the developing chick tegmentum vasculosum. Scanning Electron Microscopy/1982/III, 1283-1294.
2. Cotanche, DA, Sulik, KK. Early differentiation of hair cells in the embryonic chick basilar papilla. Arch. Otorhinolaryngol. 1983;237:191-195.
3. Cotanche, DA, Sulik, KK. The development of stereociliary bundles in the cochlear duct of chick embryos. Developmental Brain Research 1984;16:181-193.
4. Cotanche, DA, Sulik, KK. Parameters of growth in the embryonic and neonatal chick basilar papilla. Scanning Electron Microscopy/1985/I, 407-417.
5. Cotanche, DA, Cotton, CU, Gatzy, JT, Sulik, KK. Ultrastructural and electrophysiological maturation of the chick tegmentum vasculosum. Hearing Res.1987;25:125-139.
6. Cotanche, DA, Saunders, JC, Tilney, LG. Hair cell damage produced by acoustic trauma in the chick cochlea. Hearing Res. 1987;25:267-286.
7. Cotanche, DA. Development of hair cell stereocilia in the avian cochlea. Hearing Res. 1987;28:35-44.
8. Cotanche, DA. Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hearing Res. 1987;30:181-196.
9. Cotanche, DA. Regeneration of the tectorial membrane in the chick cochlea following severe acoustic trauma. Hearing Res. 1987;30:197-206.
10. Schneider , ME , Cotanche, DA, Fambrough, DM, Matschinsky, FM. The cellular distribution of the Na + -K + ATPase in the chick cochlea. Hearing Res. 1987;31:39-44.
11. Tilney, LG, Tilney , MS , Cotanche, DA. Actin filaments, stereocilia and hair cells of the bird cochlea V. How the staircase pattern of stereociliary lengths is generated. J. Cell Biol. 1988;106:355-365.
12. Corwin, JT, Cotanche, DA. Regeneration of sensory hair cells after acoustic trauma. Science 1988;240:1772-1774.
13. Tilney, LG, Tilney , MS , Cotanche, DA. New observations on the stereocilia of tall and short hair cells of the chicken cochlea. Hearing Res. 1988;37:71-82.
14. Tilney, MS, Tilney, LG, Stephens, RE, Merte, C, Drenckhahn, D, Cotanche, DA, Bretscher, A. Preliminary biochemical characterization of the stereocilia and cuticular plate of hair cells of the chick cochlea. J. Cell Biol. 1989;109:1711-1723.
15. Corwin, JT, Cotanche,DA. The development of location-specific hair cell stereocilia in denervated embryonic ears. J. Comp. Neurol.1989; 288:529-537.
16. Cotanche, DA, Dopyera, CEJ. Effects of acoustic trauma on hair cells and supporting cells in the chick cochlea. Hearing Research 1990;46:29-40.
17. Shiel, MJ, Cotanche, DA. SEM analysis of the developing tectorial membrane in the chick cochlea. Hearing Research 1990;47:147-158.
18. Cotanche, DA, Corwin, JT. Stereocilia bundles reorient during hair cell development and regeneration in the chick ear. Hearing Res. 1991;52:379-402.
19. Stone, JS, Cotanche, DA. Hair cell differentiation in the developing chick cochlea and in embryonic cochlear organ culture. J. Comp. Neurol. 1991;314:614-625.
20. Cotanche, DA. Video-enhanced DIC images of the noise-damaged and regenerated chick tectorial membrane. Experimental Neurology 1992;115:23-26.
21. Stone, JS, Cotanche, DA. Synchronization of hair cell regeneration in the chick cochlea following noise damage. J. Cell Science 1992;102:671-680.
22. Cotanche, DA, Henson, MM, Henson, OW Jr. Contractile proteins in the hyaline cells of the chicken cochlea. J. Comp. Neurol.1992; 324:353-364.
23. Tilney, LG, Cotanche, DA, Tilney, MS. Actin filaments, stereocilia and hair cells of the bird cochlea VI. How the number and arrangement of stereocilia is determined. Development 1992;116:213-226.
24. Stone, JS, Cotanche, DA. Identification of the timing of S phase and the patterns of cell proliferation during hair cell regeneration in the chick cochlea. J. Comp. Neurology 1994;341:50-67.
25. Freeman, DM, Cotanche, DA, Ehsani, F, Weiss, TF. The osmotic response of the isolated tectorial membrane of the chick to isosmotic solutions: Effect of Na + , K + , and Ca 2+ concentration. Hearing Research 1994;79:197-215.
26. Lee, KH, Cotanche, DA. Detection of ß-actin mRNA by RT-PCR in normal and regenerating chicken cochleae. Hearing Res. 1995;87:9-15.
27. Epstein, JE, Cotanche, DA. Secretion of a new basal layer of tectorial membrane following gentamicin-induced hair cell loss. Hearing Res. 1995;90:31-43.
28. Cotanche, DA, Messana, EP, Ofsie, MS. Migration of hyaline cells into the chick basilar papilla during severe noise damage. Hearing Res. 1995;91:148-159.
29. Janas, JD, Cotanche, DA Rubel, EW. Avian cochlear hair cell regeneration: stereological analyses of damage and recovery from a single high dose of gentamicin. Hearing Res. 1995;92:17-29.
30. Lee, KH, Cotanche, DA. Localization of the hair cell specific protein fimbrin during regeneration in the chicken cochlea. Audiology & Neuro-Otology 1996;1:41-53.
31. Lee, KH, Cotanche, DA. Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells. Hearing Res. 1996;94:1-13.
32. Ofsie, MS, Cotanche, DA Distribution of nerve fibers in the basilar papilla of normal and sound-damaged chick cochleae. J. Comp. Neurol. 1996;370:281-294.
33. Ofsie , MS , Hennig , AK , Messana, EP, Cotanche, DA. Sound damage and gentamicin treatment produce different patterns of damage to the efferent innervation of the chick cochlea. Hearing Res. 1997;113:207-223.
34. Hennig, A.K. and D.A. Cotanche. Regeneration of cochlear efferent nerve terminals after gentamicin damage. J. Neurosci 1998;18: 3282-3296.
35. Fernandes, R., M. Fox, D.A. Cotanche, K. Lennon, and M.A. Kukuruzinska. Confocal imaging of gene expression during hamster salivary gland biogenesis. Ann. NY Acad. Sci. 1998;842:212-216.
36. Cotanche, D.A. 1999. Can Hair Cells be Made to Regrow After Cochlear Damage? Hearing Loss 1999;20: 19-22.
37. Fernandes, R.P., Cotanche D.A., Lennon-Hopkins, K., Erkan, F., Menko, A.S., and Kukuruzinska, M.A. 1999. Differential expression of proliferative, cytoskeletal, and adhesive proteins during postnatal development of the hamster submandibular gland. Histochem. Cell Biol. 111: 153-62.
38. Kruger, R.P., R.J. Goodyear, P.K. Legan, M. Warchol, Y. Raphael, D.A. Cotanche, and G.P. Richardson. The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear. J. Neurosci. 1999;19: 4815-4827.
39. Torchinsky, C., E.P. Messana, M. Arsura, and D.A. Cotanche. 1999. Regulation of p27 Kip1 in the avian cochlea during gentamicin mediated hair cell death and regeneration. J. Neurocytol. 1999;28:913-924.
40. Roberson, D.W., J.A. Alosi, E.P. Messana, and D.A. Cotanche. Effect of violation of the labyrinth on the sensory epithelium in the chick cochlea. Hear. Res. 2000;141: 155-164.
41. Roberson, D.W., J.A. Alosi, E.P. Messana, A.P. Netter, and D.A. Cotanche. Endotracheal isoflurane anesthesia for chick auditory surgery. Hear. Res. 2000;141: 165-168.
42. Kenna, M.A., B.-L. Wu, D.A. Cotanche, B. Korf, H. Rehm. Connexin26 mutations in patients with sensorineural hearing loss. Arch Otolaryngol HNS 2001;127:1037-1042.
43. Roberson, D.W., J.A. Alosi, M. Mercola, D.A. Cotanche. Role of REST in cell fate in normal and regenerating avian auditory epithelium. Hearing Res. 2002;172:62-72.
44. Matsui, J.I., A. Haque, D. Huss, E.P. Messana, J.A. Alosi, D.W. Roberson, D.A. Cotanche, J.D. Dickman and M.E. Warchol. Hair cell function and survival following aminoglycoside treatment with caspase inhibitors in vivo. J. Neurosci. 2003; 23:6111-6122.
45. Mangiardi, D.A., K.M. Williamson, K.E. May, E.P. Messana, D.C. Mountain . and D.A. Cotanche. Progression of Hair Cell Ejection and Molecular Markers of Apoptosis in the Avian Cochlea following Gentamicin Treatment. J. Comp. Neurol. 2004; 475:1-18
46. Roberson, D.W., J.A. Alosi and D.A. Cotanche. Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium. J. Neurosci. Res. 2004, 78:461-471.
47. Wang, H., J. Li, P.L. Follett, D.A. Cotanche, J.J. Volpe and P.A. Rosenberg. 12-Lipoxygenase plays a causal role in cell death caused by glutathione depletion and arachadonic acid in cultured rat oligodendrocytes. Eur. J. Neurosci. 2004, 20:2049-2058.
48. Parker, MA, JK Anderson, DA Corliss, VE Abraira, R Sidman, KI Park, DA Cotanche, EY Snyder. Expression profile of an operationally-defined neural stem cell clone. J. Exp. Neurol., 2005, 194:320-332.
49. Dai, C.F., D.A. Mangiardi, D.A. Cotanche, and P. S. Steyger. Accumulation of fluorescent gentamicin by vertebrate sensory cells in vivo. Hearing Research 2006; 213:64-78.
50. Duncan, LJ, JK Anderson, KE Williamson, DA Mangiardi, JI Matsui, DA Cotanche. Characterization of myosin VI and VIIa distribution through gentamicin-mediated hair cell death and regeneration in the avian cochlea. J. Comp. Neurol. 2006, 499:691-701.
51. Parker, MA, DA Corliss, B Gray, N Roy, JK Anderson, RP Bobbin, EY Snyder, DA Cotanche. Neural stem cells integrate into the sound-damaged cochlea and develop into cochlear cells. Hearing Research 2007, 232:29-43.
52. Spencer NJ, DA Cotanche and CM Klapperich. Peptide and collagen based hydrogel substrates for in vitro culture of chick cochleae . Biomaterials 2008, 28:1028-1042 .
53. Kaiser CL, BJ Chapman, JL Guidi, CE Terry, DA Mangiardi, and DA Cotanche. Comparison of activated caspase detection methods in thegentamicin-treated chick cochlea Hearing Research 2008, 240:1-11.
54. Mueller MA, MD Kramer, DA Cotanche, JE Dowling, and JI Matsui. DMSO enhances cisplatin-induced hair cell death in zebrafish (Danio rerio). Hearing Research 2008, to be submitted.

 

Case Reports, Reviews, Chapters and Editorials

Proceedings of Meetings & Invited Papers:

1. Cotanche, DA, Petrell, A, Picard, DA. Structural reorganization of hair cells and supporting cells during noise damage, recovery, and regeneration in the chick cochlea. In: Bock, GR, Whelan, J, editors. Regeneration of Vertebrate Sensory Receptor Cells. Ciba Foundation Symposium 160. Chichester , UK : Wiley; 1991. p. 131-150.
2. Cotanche, DA. Hair cell regeneration in the avian cochlea. Proceedings from the Symposium “Frontiers in Hearing Research” at the opening of the Virginia Merril Bloedel Hearing Research Center . Annals of Oto- Rhino- Laryngol 1997;106(Suppl. 168):9-15.
3. Cotanche, DA, Hennig , AK , Riedl, AE, Messana, EP. Hair cell regeneration in the chick cochlea- Where we stand after ten years of work. In: Palmer, AR, Rees, A, Summerfield, AQ, Meddis, R editors. Psychophysical and Physiological Advances in Hearing- Proceedings of the XIth International Symposium on Hearing. London : Whurr Publishers Ltd; 1998. p. 122-129.
4. Cotanche, D.A. and A.K. Hennig. Loss and regeneration of cochlear hair cell innervation following sound and drug damage. In: Cell and Molecular Biology of the Ear, D. Lim, ed., Plenum, NY. 1999; pp. 133-44.
5. Cotanche, D.A., E.P. Messana, and P.A. Coutinho. Activating influences on supporting cell proliferation in the regenerating avian cochlea. Seminars in Hearing 2003, 24:167-168.
6. Cotanche, D.A. Genetic and pharmacological intervention for treatment/prevention of hearing loss. Proceedings of the ASHA 17 th Annual Research Symposium. J. Communication Disorders 2008, 41:421-43.

Editorials and Critical Reviews

1. Cotanche, DA, Lee, KH, Stone, Picard, DA. Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage: A review. Anatomy & Embryology 1994, 189:1-18.
2. Cotanche, DA, Lee, KH. Regeneration of hair cells in the vestibulocochlear system of birds and mammals. Current Opinion in Neurobiology 1994, 4:509-514.
3. Riedl. AE, Lee, KH, Moskalyk , LA , Cotanche, DA. The molecular biology of hair cell regeneration in the avian cochlea. Audiology and Neuro-Otology 1997, 2:61-70.
4. Cotanche, DA. Can Hair Cells be Made to Regrow After Cochlear Damage? In: Understanding Hair Cells: The Key to Understanding Hearing Loss, B Harris, ed. Proceedings of the 5 th Annual SHHH Research Symposium, published by SHHH, Inc., Bethesda, MD, 1998; pp. 6-8.
5. Cotanche, D.A. and E.P. Messana. Confocal Microscopy. In: Syllabus for the ARO Short Course on Anatomical Methods for Research in Otolaryngology, D.S. Whitlon, ed. 1999; pp. 31-39.
6. Cotanche, D.A. Structural Recovery from Sound and Aminoglycoside Damage in the Avian Cochlea: A Review. Audiology and Neuro-Otology 1999, 4:271-285.
7. Cotanche, D.A. Hair Cell Regeneration and the Development of a Biological Cochlear Implant. In: Biotechnology and the Cochlea, Proceedings of the First Research Symposium for Non-Scientists at the AG Bell 2000 International Convention, published by Alexander Graham Bell Association for the Deaf and Hard of Hearing, Washington, DC, 2000; pp.4-6.
8. Parker, M.A and D.A. Cotanche. The potential use of stem cells for cochlear repair. Audiology & Neuro-Otolology 2004, 9:72-80.
9. Matsui, J.I. and D.A. Cotanche. Sensory Hair Cell Death and Regeneration: Two Halves of the Same Equation. Current Opinion in Otolaryngology & Head and Neck Surgery, 2004, 12:418-425.
10. Morest, D.K and D.A. Cotanche. Regeneration of the inner ear as a model of neural plasticity. J. Neurosci Res., 2004, 78:455-460.
11. Matsui, J.I., M.A. Parker, B.M. Ryals and D.A. Cotanche. Regeneration and replacement in the vertebrate inner ear. Drug Discovery Today, 2005, 10:1307-1312.
12. Mangiardi, D.A. and D.A. Cotanche. Mechanisms of aminoglycoside-induced hair cell death. In: P. Steyger and J. Ripper, eds. Volta Review, Washington , DC : AGBell Association; 2005, 105; 357-371.
13. Stone, J.S. and D.A. Cotanche. Hair Cell Regeneration in the Avian Auditory Epithelium. Special Issue on Ear Development, International Journal of Developmental Biology. 2007, 51:633-647.

 

Textbook Chapters:

1. Cohen, G, Cotanche, DA. Development of stato-acoustic receptors and their innervation in the chick. In: Romand, R, editor. Development of Auditory and Vestibular Systems 2. Amsterdam : Elsevier; 1992. p. 101-138.
2. *Sulik, K.K. and D.A. Cotanche. Embryogenesis of the ear. In: Gorlin, RJ, Toriello, HV, Cohen, MM Jr., editors. Hereditary Hearing Loss and Its Syndromes. New York , NY : Oxford University Press; 1995. p. 22-42. *(Note: due to an editorial error the name of Douglas A. Cotanche was inadvertently omitted as an author of Chapter 4 and from the list of contributors, table of contents and first page of the chapter. An erratum has been issued to be included in the first printing and the second printing will be revised to correct the error).
3. Sulik, K.K. and D.A. Cotanche. Embryology of the ear. In: Toriello, HV, Reardon, W, Gorlin, RJ, editors. Hereditary Hearing Loss and Its Syndromes, 2 nd Edition. New York , NY : Oxford University Press; 2004. p. 17-36.
4. Ryals, B.M., J.I. Matsui and D.A. Cotanche. Regeneration of hair cells. In: C.M. Campbell, ed. Pharmacology and Ototoxicity for Audiologists, Clifton Park , NJ : Thomson Delmar Learning; 2007, pp. 301-319.
5. Cotanche, D.A. Regeneration in the cochlea. In: P. Fuchs, ed. The Oxford Handbook of Auditory Science: The Ear, Oxford , UK : Oxford University Press; 2007, submitted.