Joseph P. Gerrein
B.S., Biomedical Engineering, Columbia University, New York, NY, 2005
Early detection of lung cancer using nasal epithelium gene expression. The goal of this project is to establish biomarkers in nasal epithelium for the early detection of lung cancer. Our group has previously shown that smoking creates a field of injury that affects the bronchial and nasal epithelium gene expression similarly. In addition, the bronchial epithelium gene expression can be used to diagnose lung cancer. The establishment of a lung cancer biomarker in nasal epithelium would enable less invasive diagnosis and potentially a large-scale screening tool.
Discovery of novel microRNAs in the human airway that are associated with smoking and/or lung cancer. The goal of this project is to detect novel microRNAs in the human airway that are associated with lung cancer and/or smoking. Novel microRNAs are predicted computationally from the RNA-seq data and a select number of predicted microRNAs are experimentally validated , functionally characterized, and evaluated for use as biomarkers.
Kallwass H, Carr C, Gerrein J, Titlow M, Pomponio R, Bali D, Dai J, Kishnani P, Skrinar A, Corzo D, Keutzer J. Rapid diagnosis of late-onset Pompe disease by fluorometric assay of alpha-glucosidase activities in dried blood spots. Mol Genet Metab. 2007 Apr;90(4):449-52. PMID:17270480
Kherlopian AR, Gerrein JP, Yue M, Kim KE, Kim JW, Sukumaran M, Sajda P. Electrooculogram based system for computer control using a multiple feature classification model. Conf Proc IEEE Eng Med Biol Soc. 2006;1:1295-8. PMID:17946887
Gerrein JP, Kherlopian AR, Berman M, Wu V, Wald A. MedfoLink: Bridging the Gap between IT and the Medical Community. Proceedings of the Computational Systems Bioinformatics 2003 (CSB’03)