Ying Shen, Ph.D.
B.S., Biological Sciences, Fudan University, Shanghai, China, 2006
M.S., Statistics, Georgia Institute of Technology, Atlanta, Georgia, 2010
Ph.D., Biology, Georgia Institute of Technology, Atlanta, Georgia, 2011
My research focuses on the development and application of computational and statistical methods for optimizing personalized medicine. My current research project is to develop Bayesian regression-based approaches for identifying pathway and drug signatures from cancer cell lines and projecting signatures into patient samples. We will integrate gene expression signatures with SNP variation and other genetic/genomic factors to optimize personalized treatment regimes.
Shen, Y., Koh, K., Weiss, B., and Storici, F. (2011) Mispaired rNMPs are mutagenic and are targets of mismatch repair and RNases H. Nat. Struct. Mol. Biol. 19(1), 98-104
Shen, Y., Nandi, P., Taylor, M.B., Stuckey, S.A., Bhadsavle, H. P., Weiss, B., and Storici, F. (2011) RNA-driven genetic changes in bacteria and in human cells. Mutat. Res. 717, 91-98
Shen, Y. and Storici, F. (2011) Detection of RNA-templated double-strand break repair in yeast. Methods Mol. Biol. 745, 193-204
Shen, Y. and Storici, F. (2010) Generation of RNA/DNA hybrids in genomic DNA by transformation using RNA-containing oligonucleotides. J. Vis. Exp. 45