Images
Creekmur Images, October 28, 2009
Creekmur Images (October 28, 2009) -- Three brain sections from Mr. Creekmur showing dense tau deposits (brown) in the insula (1), temporal (2) and frontal (3) cortices, amygdala (4) and hippocampus (5) in the absence of beta amyloid plaques. A normal control brain would not show any brown discoloration.
Borich Images (October 22, 2009) -- Figure 1: Photomicrographs of normal control brain (top panels) and the brain of Mike Borich (bottom panels), immunostained for tau protein (brown) and counterstained with cresyl violet (purple). Virtually no tau deposition is found in the normal control brain whereas numerous tau containing neurofibrillary tangles are found in individual nerve cells of the brain of Mike Borich (asterisks).
Borich Images (October 22, 2009) -- Figure 2: Whole mount hemi-sections of the brain immunostained for tau protein (brown) and counterstained with cresyl violet (purple) : 61 year old normal control (left) ; 42 year old Mike Borich (right). The normal brain shows no tau deposition, whereas the brain of Mike Borich shows extensive tau deposition throughout the frontal (1) and temporal (2) gray matter.
January 2009 Announcement Images -- Image 1: 18-year old high school football player
Image 1
18-year old high school football player
Top left: Whole mount section of frontal cortex showing very focal deposition of tau protein around small blood vessels (red box).
Bottom left: high magnification shows dense tau immunoreactive NFTs around small blood vessels (holes) and extensive tau immunoreactive neurites in the neuropil immediately surrounding the area.
Top right: Another whole mount section of frontal and insular cortex showing very focal deposition of tau protein around a small blood vessel in insulara cortex (red box).
Bottom right: high magnification shows dense tau immunoreactive NFTs around a small blood vessel (hole) and tau immunoreactive neurites in the neuropil immediately surrounding the area.
January 2009 Announcement Images -- Image 2: Thomas McHale, 45-year old NFL player
Image 2
Thomas McHale: 45-year old NFL player
Top left: Whole mount section of neocortex immunostained for tau protein showing extensive deposition of tau protein as neurofibrillary tangles throughout the neocortex Bottom left: high magnification photomicrograph of neocortex howing innumerable tau immunoreactive neurofibrillary tangles and neuropil neurites
Top right: Whole mount section of amygdala immunostained for tau protein showing dense, patchy deposition of tau protein Bottom right: high magnification photomicrograph showing tau immunoreactive neurofibrillary tangles and neuropil neurites in the amygdale.
January 2009 Announcement Images -- Image 3: Thomas McHale: 45-year old NFL player
Image 3
Thomas McHale: 45-year old NFL player
Top left: Whole mount section of inferior orbital cortex immunostained for tau protein showing dense, patchy deposition of tau protein Bottom left: high magnification photomicrograph sof inferior orbital cortex howing numerous tau immunoreactive neurofibrillary tangles and neuropil neurites
Top right: Whole mount section of hippocampus and temporal cortex immunostained for tau protein showing dense, patchy deposition of tau protein.
Bottom right: high magnification photomicrograph showing numerous tau immunoreactive neurofibrillary tangles and neuropil neurites in the hippocampus
January 2009 Announcement Images -- Image 4: 65-year old control
Image 4
65-year old control
Top left: whole mount section of medial temporal lobe immunostained for tau protein showing no immunoreactivity.
Bottom Left: high magnification photomicrograph of amygdala showing only extremely rare tau immunoreactivity.
Top Right: whole mount section of frontal cortex immunostained for tau protein showing no immunoreactivity.
Bottom right: high magnification photomicrograph of frontal cortex showing only no tau immunoreactivity.
September 2008 Announcement Images
- September 2008 Announcement Images — Figure 1
Figure 1 legend
Tau immunostained sections of medial temporal lobe; tau protein = dark brown color
Left (top ): Whole brain section from a 65 year old control subject showing no abnormal tau protein deposition
Left (bottom): Microscopic section from 65 year old control subject also shows no abnormal tau protein deposition
Middle top: Whole brain section from John Grimsley showing abundant tau protein deposition in the brain.
Middle bottom: Microscopic section showing numerous tau containing neurofibrillary tangles in the brain.
Right top: Whole brain section from a 73 year old world champion boxer with end stage CTE and dementia showing very severe tau protein deposition
Right bottom: Microscopic section from a 73 year old world champion boxer with end stage CTE and severe dementia showing abundant tau containing neurofibrillary tangles
- September 2008 Announcement Images — Figure 2
Figure 2 legend
Tau immunostained sections of frontal cortex; tau = dark brown color
Left (top): Whole brain section from a 65 year old control subject showing no abnormal tau protein deposition
Tau immunostained sections of frontal cortex; tau = dark brown color
Left (top): Whole brain section from a 65 year old control subject showing no abnormal tau protein deposition
Left (bottom): Microscopic section from 65 year old control subject also shows no abnormal tau protein deposition
Middle top: Whole brain section from John Grimsley showing abundant tau protein deposition in the brain.
Middle bottom: Microscopic section showing numerous tau containing neurofibrillary tangles in the brain.
Right top: Whole brain section from a 73 year old world champion boxer with end stage CTE and dementia showing very severe tau protein deposition
Right bottom: Microscopic section from a 73 year old world champion boxer with end stage CTE and severe dementia showing abundant tau containing neurofibrillary tangles
