Alphabetical CMB faculty list
Faculty belong to many different departments and have many different interests. If you are interested in a person please go first to pubmed and read some of their articles and then contact the faculty person and set up a meeting to speak with them.
Carmela Abraham, PhD
Amyloid and inflammation in the brain during normal aging and Alzheimers disease
Xingbin Ai, PhD
Matrix dependent mechansims that regulate extracellular signalling during embryogenesis and regeneration, functions of heparan sulfate editing enzymes (Sulfs) in the skeletal and nervous system
Christopher Akey, PhD
Structural biology of channels and chaperones
Kenneth Albrecht, PhD
Mechanism of human sex reversal and adrenal dysmorphogenesis, gonad development
*Karen Allen, PhD
Protein structure and function using x-ray crystallography and kinetics
Salomon Amar, DMD, PhD
Molecular and cellular events associated with inflammatory processes; emphasis is placed on the cytokine control of gene expression with potential applications into various animal models.
Brygida Berse, PhD
Signal transduction pathways regulating gene expression in neuronal cells
J. Krzysztof Blusztajn, PhD
Acetylcholine synthesis and release; signal transduction by lipid messengers
Victoria Bolotina, PhD
Cardiovascular diseases, ion channels and mechanisms of calcium signaling
Steven Bogen, MD, PhD
Monoclonal gammopathies, solid tumor detection
Esther Bullitt, PhD
Protein structure and function by electron microscopy
Wellington Cardoso, MD, PhD
Mechanisms that regulate lung development
Herbert Cohen, MD
Molecular basis of renal cancer, renal cystic disease and renal development
Richard A. Cohen, MD
Nitric oxide regulation of vascular cells, oxidative stress and atherosclerosis
Wilson Colucci, MD
Mechanisms that mediate myocardial remodeling and failure
John H. Connor, PhD
Determining how viruses interact with infected cell hosts, mechanisms controlling switch to viral translation, use of VSV in targeting destruction of tumor cells
Lawreen H. Connors, PhD
Role of protein structure in mechanisms of systemic forms of amyloidosis
Barbara Corkey, PhD
Metabolic regulation of signal transduction, calcium handling and fatty acyl CoA in pancreatic beta cells and fat cells
R.B. Corley, PhD
Chair of Microbiology
M. Carter Cornwall, PhD
Visual transduction and light adaptation in rods and cones of the vertebrate retina
Catherine E. Costello, PhD
Biopolymer studies based on development and application of mass spectral studies; glycobiology
Douglas Cotanche, PhD
Hearing, actin, regeneration of hair cells
Shoumita Dasgupta, PhD
Admissions Committee
Gerald Denis, PhD
Non-Hodgkin’s lymphoma, Function of the BRD2 gene in normal and diseased B cells
Isabelle Dominguez, PhD
To characterize the mechanism of Wnt signaling in development and cancer. We are studying the function, regulation and mechanism of action of two components of the Wnt pathway: the serine-threonine kinases CK2 and GSK3beta.
Douglas Faller, MD, PhD
Molecular and cellular biology of virus and oncogene-transformed cells and tumors
Stephen Farmer, PhD
Tissue specific gene expression; role of matrix interactions and cell morphology
Rachel Fearns, PhD
Molecular biology of human respiratory syncytial virus, control of virus gene expression and genome replication
Caroline Genco, PhD
Characterization of bacterial virulence factors produced by mucosal pathogens
Terrell Gibbs, PhD
Modulators of amino acid receptor function in the brain
David A. Goukassian, MD, PhD
Cellular responses to UV-induced DNA damage, development of novel treatment for UV induced human tumors
Rahm Gummuluru, PhD
Virus-host interactions in HIV-1 pathogenesis
Hwai-Chen Guo, PhD
Protein structure/function using x-ray crystallography and molecular biology
Olga Gursky, PhD
Folding structure and stability of apolipoproteins
James A. Hamilton, PhD
Lipid/protein interactions and lipid/membrane dynamics
James Head, PhD
Regulatory role of high affinity intracellular calcium binding proteins
Andrew Henderson, PhD
Interested in investigating how cellular signals regulate HIV transcription and replication
Alan Herbert, MBChB, PhD
Gene discovery, genome wide screen to type high density of single nucleotide polymorphisms in families, identifying novel classes of coRNAs and their impact on alternative splicing of RNA
Carlos Hirschberg, PhD
Novel regulation of posttranslational modifications in mammals and yeast
Michael Hollick, MD, PhD
Physiology and molecular biology of skin and bone, vitamin D and peptide hormones
Kevin Jarrell, PhD
Molecular mechanisms of RNA splicing and catalysis
Konstantin Kandror, PhD
Regulated vesicle traffic in different eukaryotic cells
Kathrin Kirsch, PhD
Molecular mechanisms important for tumor initiation and progression with interest on adapter proteins
Darrell Kotton, MD
Stem cell biology and gene therapy, embryonic lung development and repair
Neil Kowall, MD
Mechanisms of cell death in the central nervous system
Maria Kukuruzinska, PhD
Protein N-glycosylation in growth and development
Shinichiro Kurosawa, MD, PhD
New therapeutics and novel diagnostics for patients using in vitro approaches, and exploring model systems, Sepsis, Inflammation, Thrombosis and Hemostasis.
Robert Lafyatis, MD
Regulation of sclerosis, member of Scleroderma Program
Matthew Layne, PhD
Transcriptional control of genese upregulated in vascular smooth muscle cells and fibroblasts in cardiovascular and pulmonary disease
William J. Lehman, PhD
Structural studies on actin filament function
Adam Lerner, MD
Apoptosis in lymphoid malignancies and role of adhesion-associated proteins in breast cancer anti-estrogen resistance
David E. Levin, PhD.
The Levin lab uses yeast as a model system for the molecular genetic dissection of stress signaling pathways. We are interested in the mechanisms by which fungal cells maintain the structural integrity of their cell walls in response to osmotic stress and other challenges. Our work is directed at the identification of potential anti-fungal drug targets in pathogenic species.
Jennifer I. Luebke, PhD
Normal aging and Alzheimer’s disease
Zhijun Luo, PhD
Regulation and function of Raf kinase and AMP-activated protein kinase, both of which have been implicated in cancer and other diseases
Assen Marintchev, PhD
Our work is focused on studying the architecture of the translation initiation complexes, the molecular mechanisms of key steps in the process, and their regulation. The long-term goal is to build a detailed mechanistic and quantitative model of translation initiation as a whole, and learn how to rationally manipulate the system for the purposes of cancer therapy and treatment of metabolic disorders. Two areas of particular interest are the coordination between start codon selection and ribosomal subunit joining and the regeneration of the eIF2-GTP:Met-tRNAi complex.
Jay Mizgerd, ScD
Innate immunity, lung infections, transcriptional and post-transcriptional regulation of cytokines
C. James McKnight, PhD
Protein structure/function and folding using NMR
Jeffrey R. Moore, PhD
Cystoskeletal dynamics and motor proteins
Gustavo Mostoslavsky, MD, PhD
Stem cell biology and gene therapy; embryonic stem cell modeling of intestinal differentiation
Mary Jo Murnane, PhD
Tumor markers within a proteolytic cascade in tumorogenesis
Director of Admissions
George J. Murphy, PhD
Stem cells
John R. Murphy, PhD
Diphtheria toxin repressor; diphtheria toxin catalytic domaina nd entry into eukaryotic cell cytosol, protein structure function
Caryn Navarro, PhD
Mutation of the dynein complex (molecular motors) can lead to loss of function of the dynein associated protein Lissencephaly 1 (Lis-1) and neurodegenerative disease due to a lack of neuronal migration. Lis-1 is important for RNA localization, cell division and nuclear migration. My goal is to understand the mechanisms of dynein directed molecular transport and how intracellular transport is affected by mutations in piRNA (piwi-interacting) pathway components.
Barbara Nikolajczyk, PhD
Activation of immunologically critical genes in context of chromatin, regulation of IL-1 beta gene transcription, inflammation in type 2 diabetes,
Matthew Nugent, PhD
Cell proliferation, growth factor-receptor interactions, proteoglycans, extracellular matrix
Gwynneth Offner, PhD
Epithelial protection and repair; structure, function and regulation of both membrane bound and secreted mucins. Mucins protect normal cells from a variety of environmental insults and are critical signaling mediators as they transduce extracellular stimuli into cellular responses. The membrane mucin, MUC1, which is overexpressed in many cancers leads to altered cell-cell and cell-matrix interactions and the development of the metastatic phenotype.
Paul Pilch, PhD
Membrane trafficking and cell biology of insulin action
Nader Rahimi, PhD
Receptor tyrosine kinase regulationn of angiogenesis and signal transduction
Maria Ramiriz, PhD
To identify the molecular mechanisms that drive the formation of different lineages of lung epithelial cells during development
Katya Ravid, PhD
Genetic and signaling mechanims regulating blood cell development; vascular biology
Daniel G. Remick, MD
Inflammatory response; soluble mediators of inflammation, role of inflammatory response on tissue/organ injury and death
Ian Rifkin, MD
Association of autoantibodies to nucleic acids as potential activators of innate immunity, systemic lupus erythematosus
Phillip W. Robbins, PhD
Glycoprotein processing and secretion
Carol Rosenberg, MD
Breast Cancer, molecular biological mechanisms
Douglas Rosene, PhD
Neurobiological basis of normal learning and memory in normal brain and in neurodegenerative diseases
Sayon Roy, PhD
Diabetic retinopathy, regulation of extracellular matrix
Neil Ruderman, PhD, D.Phil
Insulin action, gene expression and diacylglycerol protein kinase C in skeletal muscle
Shelley Russek, PhD
Gene expression in neurons, tissue specific promoters as targets for therapeutic targets
Miklos Sahin-Toth,MD, PhD
Proteases and their inhibitors in the pathogenesis of pancreatitis/crystallography of mutated trypsinogens
David Salant, MD
Glomerular epithelial biology, proteomic analysis of components that constitute the glomerular filtration barrier
John C. Sammuelson, MD, PhD
Pathogenesis and evolution of parasites that cause disease
Ivelisse Sanchez, PhD
Neurodegenerative diseases
Barbara Schreiber, PhD
Atherosclerosis and aortic smooth muscle cells, effect of atherotgenic lipoproteins on proliferation and biosynthesis of collagens and apolipoproteins
John H. Schwartz, MD
Targeting of proteins in epithelial transport, renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells
Barbara Seaton, PhD
Structure/function using x-ray crystallography and other biophysical/biochemical technologies
David Seldin, MD, PhD
Oncogenes and tumorogenesis as modeled in transgenic mice, Dir. of Amyloid Program
Jacqueline Sharon, PhD
Generation and use of polyclonal antibody libraries for therapeutics and diagnostics
Michael Sherman, PhD
Molecular mechanisms underlaying role of heat shock protein Hsp72 in prevention of cell death
David Sherr, PhD
Mechanisms through which environmental chemicals suppress immune apoptosis, moleular signaling leading to carcinogenic and spontaneous breast cancers
Barbara Smith, PhD
Changes in gene expression of connective tissue components associated with transformation and differentiation
Jean-Jacques Soghomonian, PhD
Neuroanatomy of the basal ganglia, neurobiological basis of motor control, sensoriomotor and learning
Gail Sonenshein, PhD
Role of oncogenes in control of cell proliferation, apoptosis and neoplastic transformation
Deborah Stearns-Kurosawa, PhD
Sepsis and pathophysiology of anthrax
Karen Symes, PhD
Role of cell-cell interaction in embryonic development
Sam Thiagalingam, PhD
Smad signaling and cancer metastasis; role of p53 in genome stability; genetic susceptibility and molecular markers of lung cancer
Phillip Trackman, PhD
Gene regulation of extracellular matrix diseases
Vickery Trinkaus-Randall, PhD
Signal transduction mechanisms of wound repair, Amyloid and fibril formation, regulation of P2X7 in development and wound repair
Gregory Tullis, PhD
Molecular understanding of retinal degenerative diseases using gene therapy
Gregory A. Viglianti, PhD
Molecular biology of HIV-1; role of virus-host cell interactions in pathogenesis
Kenneth Walsh, PhD
Signalling and transcriptional-regulatory mechanisms that control normal and pathological tissue growth in the cardiovascular system
Benjamin Wolozin, MD, PhD
Pathophysiology of neurodegenerative diseases;Alzheimers and Parkinsons, genetic models in cell culture
Zhi-Xiong Jim Xiao, PhD
Tumor suppressor genes in cell cycle, proliferation and differentiation
Qian Yu, PhD
Tyrosine phosphorylation, cell signaling, apoptosis and metastasis
Joseph Zaia, PhD
Structure and function of proteoglycans and glycosaminoglycans using mass spectrometry as a primary tool
Irina V. Zhdanova, MD, PhD
Role of endogenous factors secreted into the cerebrospinal fluid and/or blood circulation in sleep regulation; interested in the effects of these factors on sleep, cognitive performance and drug abuse
Vassilis I. Zannis, PhD
Mechanisms of transcriptional regulation of apolipoprotein genes in vivo and in vitro, transgenic mice, adenovirus-mediated gene transfer
R. Andrew Zoeller, PhD
Somatic cell genetics to define roles of lipids in stroke, myocardial infarction and neurodegerative diseases
*Dr. Allen has moved to the Charles River Campus in the Department of Chemistry.
