What’s New

First signal! reported in cryo FTMS lab. Read the June 2007 NewsSpots for more NHLBI Proteomics Initiative news.

Report on OPTM 2006 Symposium

Map your BU location! Check out this link to map your routes around campus and to measure campus distances.

In 2007 compared to recent years, NHLBI paylines show improvement in R01 New Investigator category only. Read all at: NHLBI payline policy.

chart of uptake of apoptotic debris vs. control, from Walsh publication
Uptake of apoptotic debris vs. control

CPC hosted the 9th NHLBI Investigators’ Meeting of the Proteomics Initiative on April 18 and 19, 2007. The two-day program, consisting of closed networking sessions on the first day and open research session on the second day, highlighted research of the 10 Centers and featured junior investigators, informal networking, CPC laboratory techniques, and a symposium with invited speakers, open to all. Meeting attendees rated the meeting 1.9, and want to continue the symposium concept.

A new role for fat has been proposed by project 8 researchers, led by Dr. Kenneth Walsh, in the January Journal of Clinical Investigation. Come hear them present the research Aug. 24, 10:30 am, conference rooms 107/108, 670 Albany St. Spotlight, publication.

Quantification of oxidative post-translational modifications of cysteine thiols of p21ras demonstrates the potential importance of redox modulation of its function, published in Free Radical Biology & Medicine, March 2007, by project 2 researchers. Spotlight.

Investigators are beginning to publish in open access journals, as PLoS Biology, where the project 6 team published in January their results of large-scale mapping of E. coli transcriptional regulation. The investigators use computational tools that predict regulatory pathways with great accuracy and can be used for sample classification and relative quantification in proteomics analysis of complex data sets.

Pictures, 9th NHLBI Proteomics Initiative Investigators Meeting, BUSM

Investigator's Meeting, BUSM, Simon Letarte in poster session 9th Investigator's Meeting, BUSM, Dean Karen Antman addressing audience 9th Investigator's Meeting, BUSM, Raman Mathur describing FTMS amplifiers

image of Claire Dauly
Claire Dauly		 Joseph Zaia, Ph.D., Research Associate Professor of Biochemistry, is newly a member of our proteomics center. As Associate Director of the Mass Spectrometry Resource, he has directed the Shared Mass Spectrometry Instrument Laboratory for many years and now will provide consultation on experimental setup, instruction, and assistance in data interpretation related to innovative protein analyses using a newly-installed ThermoFisher LTQ-Orbitrap mass spectrometer within the lab. Recently we said goodbye to Cheng Zhao, Ph.D., Mahadevan Sethuraman, Ph.D., Tyler Heibeck, Ph.D., and Claire Dauly. Congratulations to Vera Ivleva, now a Ph.D., who defended her thesis, “Direct coupling of thin layer chromatography with vibrationally cooled MALDI-MS for the analysis of glycolipids from biological samples” in April. image of Vera Ivleva
Vera Ivleva

Report on OPTM 2006 Symposium        OPTM 2006 Abstract Book      OPTM 2006 Program    OPTM conference hightlights
The second “Oxidative Post-Translational Modifications in the Cardiovascular System” symposium took place Oct. 3-6, 2006 with over 100 scientists in attendance. The Scientific Advisory Committee is reviewing presentations to select travel and science awards.

RECENT ABSTRACTS/PUBLICATIONS

Milestones and Advancements on the Plan — Annual Report 2006   

BUPID software is available online to the research community by the Bioinformatics project.

The NHLBI Proteomics Initiative’s NewsSpots is here, with coverage of recent CPC research.

Proteomics Informatics and Genetic Immunization courses coming up at other NHLBI Proteomics Centers.

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