What We Do
The Cardiovascular Proteomics Center (CPC) is a research institute within Boston University School of Medicine that analyzes protein variations caused by oxidative stress. In particular, the CPC is investigating post-translational modifications that may be important in the signalling mechanisms of proteins that are altered by oxidative chemical reactions in cardiovascular disease. One such chemical reaction is the production of reactive oxygen species, highly reactive molecules that arise from incomplete chemical reaction of oxygen. Cells and organisms under oxidative stress produce reactive oxygen species (ROS); ROS can cause tissue damage but also are involved in the regulation of cell growth, consequently they are important for the study of biochemical processes in normal and diseased cells. Oxidative stress is a widespread condition influenced by smoking, other lifestyle and environmental processes, as well as exposure to ionizing radiation.
Boston University School of Medicine successfully competed for the NIH/NHLBI‘s Proteomics Initiative, which led to the establishment of this line of research under the Cardiovascular Proteomics Center in 2002. Catherine E. Costello, Ph.D., is principal investigator of this center, one of the 7 centers currently funded under the Initiative. The Center was re-funded in 2010, permitting activities to be reinforced and revitalized with a thrust which includes clinical research in conjunction with the BMC Cardiomyopathy Program.
To study oxidative post-translational modifications in cardiovascular disease, the CPC is developing a variety of novel sample handling methods and high performance instruments. A wide variety of faculty, researchers and disciplines are united under CPC to conduct this research, true to the multi-disciplinary and translational nature of biomedical research today. The Core Laboratory is perfecting high throughput mass spectrometry using electrospray ionization and LC-MS/MS methodology developed in the mass spectrometry field over the last decade. Instrumentation development is focused on building a new and higher performance MALDI-FTMS instrument.