Boston University Medical Campus
Cardiovascular Proteomics Center

CPC Research at the AHA

AHA 2007

To be presented at the AHA’s 2007 Scientific Sessions in Orlando, Florida, Nov 4-7, 2007:

• Lancel S, Zhang J, Kuster GM, Ying J, Pimentel DR, Trucillo MP, Weinberg EO, Siwik DA, Cohen RA, Colucci WS. Hydrogen Peroxide-Induced Contractile Dysfunction is Mediated Through Oxidation of SERCA on Cysteine-674;
• Lancel S, Qin F, Trucillo MP, Lennon SL, Communal C, Xu S, Weinberg EO, Siwik DA, Cohen RA, and Colucci WS. Dilated Cardiomyopathy and Progressive Myocardial Failure in GƒÑq Over-expressing Mice are Associated with Transcriptional and Oxidative Post-Translational Modifications of RyR2 and SERCA2.

AHA 2006

The AHA Scientific Sessions, held in Chicago, Ill., Nov 12-15, 2006 featured oxidative post-translational modifications in special sessions and highlighted the 10 NHLBI-funded Proteomics Initiative Centers. In the session entitled, “Diagnosis, Prognosis, and Risk Assessment: The Potential of Clinical Proteomics,”

• Jennifer Van Eyk, principal investigator of the Johns Hopkins center, presented “Discovery of Novel Biomarkers for Ischemic Heart Disease.”
• P. J. Utz, Stanford University’s center, “Monitoring Autoantibody Response of the Cellular Proteome.”
• Richard A. Cohen, Boston University’s center, who studies 3-Nitrotyrosine and Thiols, presented “Monitoring Oxidation for Cardiovascular Stress.”

CPC research presented there:

• Handy DE, Yang Y, Lubos E, Galbraith JD, Leopold JA and Loscalzo. Glutathione Peroxidase-1 (GPx-1) Overexpression Alters Receptor-mediated Signaling by Regulating Intracellular Levels of Reactive Oxygen Species. The investigators are working on Post-translational Modification of Vascular Proteins by Homocysteine.
• Qin F, Biolo A, Siwik DA, Pimentel DR, Ip P, Dorn GW, Kang J, Colucci WS. Cardiac-specific Overexpression of Catalase Prevents Progressive Left Ventricular Remodeling and Failure in Gaq-overexpression Transgenic Mice. This abstract comes from project 12 research.
• Rex S, Perlman DH, Vitseva O, Blair PS, McComb MD, Costello CE, Freedman JE. Immune vs. Thrombotic Stimulation of Platelets Differentially Regulates Intracellular Protein Associations and Protein Release: a Proteomics Analysis. The research is a collaboration between the Circulating Surrogate Target Cells of Oxidant Stress project and the Core Laboratory.

AHA 2005

At the 2005 meetings in Dallas, Texas:

• Two papers from the “Circulating Surrogate Target Cells of Oxidant Stress” project were presented: Sybille Rex, Price S. Blair, David H. Perlman, Hua Huang, Mark E. McComb, Catherine E. Costello, and Jane E. Freedman, “Proteomics Analysis of Toll-Like Receptor 2 and Intracellular Factor XIIIA in Platelets: Functional Implications in Immune Defense,” and
• Price S. Blair, Sybille Rex, Kahraman Tanriverdi, Olga Vitseva, Mark D. Iafrati, and Jane E. Freedman, “The Expression of Toll-like Receptors on Human Platelets.”
• Ramachandran S. Vasan, investigator of the NHLBI’s Framingham Heart Study and project leader of “Impact of Oxidative Stress on Cardiovascular Diseases in the Community,” presented, “Are All ‘Normal’ Aldosterone Levels Normal?”
• Kenneth Walsh, project leader of “Circulating Endothelial Progenitor Cells”, presented a seminar entitled, “Reprogramming Cardiac Structure/Function at the Cellular and Organ Level With Akt.”
• Harrison W. Farber, project leader of “Proteomic Markers of Endothelial Damage and Oxidative Stress in Sickle Cell Disease,” gave a How-to seminar.