Publications 2010-2012

Bachschmid, M. M.; Schildknecht, S.; Matsui, R.; Zee, R.; Hauessler, D.; Cohen, R. A.; Pimental, D.; Loo, V. B.Vascular Aging: Chronic Oxidative Stress and Impairment of Redox Signaling-Consequences for Vascular Homeostasis and Disease. Ann Med 20112012 Mar 1. PubMed PMID: 22380696.

Biolo, A.; Fisch, M.; Balog, J.; Chao, T.; Schulze, P. C.; Ooi, H.; Siwik, D.; Colucci, W. S. Episodes of Acute Heart Failure Syndrome are Associated with Increased Levels of Troponin and Extracellular Matrix Markers. Circ Heart Fail. 2010, 3, 44-50. PubMed PMID: 19850700.

Burgoyne, J. R.; Haeussler, D. J.; Kumar, V.; Ji, Y.; Pimental, D. R.; Zee, R. S.; Costello, C. E.; Lin, C.; McComb, M. E.; Cohen, R. A.; Bachschmid, M. M.Oxidation of HRas Cysteine Thiols by Metabolic Stress Prevents Palmitoylation. in vivo and Contributes to Endothelial Cell Apoptosis.” FASEB J. 2012, 26, 832-841. [Epub 2011 Nov 15]. PubMed PMID: 22085642; PubMed Central PMCID: PMC3290434.

Cohen, R. A.; Tong, X. Vascular Oxidative Stress: the Common Link in Hypertensive and Diabetic Vascular Disease. J. Cardiovasc. Pharmacol. 2010, 55, 308-316. PubMed PMID: 20422735 PubMed Central PMCID: PMC3018745.

Evangelista, A. M.; Thompson, M. D.; Weisbrod, R. M.; Pimental, D. R.; Tong, X. Y.; Bolotina, V. M.; Cohen, R. A. Redox Regulation of SERCA2 Is Required for Vascular Endothelial Growth Factor-Induced Signaling and Endothelial Cell Migration. Antioxid Redox Signal. 2012 [Epub May 31.] PubMed PMID: 22472004.  

Kuster, G. M,; Lancel, S.; Zhang, J.; Communal, C.; Trucillo, M. P.; Lim, C. C.; Pfister, O.; Weinberg, E. O.; Cohen, R. A.; Liao, R.; Siwik, D. A.; Colucci, W. S. Redox-mediated Reciprocal Regulation of SERCA and Na+-Ca2+ Exchanger Contributes to Sarcoplasmic Reticulum Ca2+ Depletion in Cardiac Myocytes. Free Radic. Biol. Med. 2010, 48, 1182-1187. PubMed PMID: 20132882 PubMed Central PMCID: PMC2847633.

Kumar, V.; Calamaras, T. D.; Haeussler, D. J.; Colucci, W.; Cohen, R. A.; McComb, M. E.; Pimental, D. R.; Bachschmid, M. M. Cardiovascular Redox and Ox Stress. Proteomics. 2012 [Epub May 18] PubMed PMID: 22607061.  

Lancel, S.; Qin, F.; Lennon, S. L.; Zhang, J.; Tong, X.; Mazzini, M. J., Kang, Y. J.; Siwik, D. A.; Cohen, R. A.; Colucci, W. S. Oxidative Post-translational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in Gαq-overexpressing Mice. Circ. Res., 2010, 107, 228-32. PubMed PMID: 20508180 PubMed Central PMCID: PMC2909347.  

Legrain, P.; Aebersold, R.; Archakov, A.; Bairoch, A.; Bala, K.; Beretta, L.; Bergeron, J.; Borchers, C.; Corthals, G. l.; Costello, C. E.; Deutsch, E. W.; Domon, B.; Hancock, W.; He, F.; Hochstrasser, D.; Marko-Varga, G.; Salekdeh, G. H.; Sechi, S.; Snyder, M.; Srivastava, S.; Uhlén, M.; Wu, C. H.; Yamamoto, T.; Paik, Y.-K.; Omenn, G. S. The Human Proteome Project: Current State and Future Direction. Mol. Cell. Proteomics, 2011, 10:M111.009993. [Epub Apr 29] PubMed PMID: 21531903.

Leymarie N, McComb ME, Naimy H, Staples GO, Zaia J. Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Int. J. Mass. Spectrom. 2012, 312, 144-154. [Epub 2011 Jul 23]. PubMed PMID: 22523474 PubMed Central PMCID:PMC3329220

Li, X.; Yu, X.; Costello, C. E.; Lin, C.; O’Connor, P. B. Top-down Study of β2-Microglobulin Deamidation. Anal. Chem., 2012. [Epub Jun 18] DOI: 10.1021/ ac3009324

Li, Y.; Xu, S.; Mihaylova, M. M.; Zheng, B.; Hou, X.; Jiang, B.; Park, O.; Luo, Z.; Lefai, E.; Shyy, J. Y.; Gao, B.; Wierzbicki, M.; Verbeuren, T. J.; Shaw, R. J.; Cohen, R. A.; Zang, M. AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin-resistant Mice. Cell Metab. 2011, 13, 376-388. PubMed PMID: 21459323; PubMed Central PMCID: PMC3086578.

Liesa, M.; Luptak, I.; Qin, F.; Hyde, B. B.; Sahin, E.; Siwik, D. A.; Zhu, Z.; Pimentel, D. R.; Xu, X.J.; Ruderman, N. B.; Huffman, K. D.; Doctrow, S. R.; Richey, L.; Colucci, W. S.; Shirihai, O.S. Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid is a Novel Gene Required for Cardiac Recovery after Ischemia/Reperfusion. Circulation. 2011, 124, 806-813. [Epub Jul 25]. PubMed PMID: 21788586.

Mazzini, M.; Tadros, T.; Siwik, D.; Joseph, L.; Bristow, M.; Qin, F.; Cohen, R.; Monahan, K.; Klein, M.; Colucci, W. Primary Carnitine Deficiency and Sudden Death: in vivo Evidence of Myocardial Lipid Peroxidation and Sulfonylation of Sarcoendoplasmic Reticulum Calcium ATPase 2. Cardiology. 2011, 120, 52-58. [Epub Nov 24] PubMed PMID: 22116472.

Papanicolaou, K. N.; Khairallah, R. J.; Ngoh, G. A.; Chikando, A.; Luptak, I.; O’Shea, K. M.; Riley, D. D.; Lugus, J. J.; Colucci, W. S.; Lederer, W. J.; Stanley, W. C.; Walsh, K. Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-induced Permeability Transition in Cardiac Myocytes. Mol. Cell Biol. 2011, 31, 1309-1328. [Epub Jan 18] PubMed PMID: 21245373; PubMed Central PMCID: PMC3067905.

Pimentel, D.; Haeussler, D. J.; Matsui, R.; Burgoyne, J. R.; Cohen, R. A.; Bachschmid, M. M. Regulation of Cell Physiology and Pathology by Protein S-glutathionylation: Lessons Learned from the Cardiovascular System. Antioxid. Redox Signal. 2012, 16, 524-542. PubMed PMID:2010840; PubMed Central PMCID: PMC3270052.

Qin, F.; Siwik, D. A.; Luptak, I.; Hou, X.; Wang, L.; Higuchi, A.; Weisbrod, R. M.; Ouchi, N.; Tu, V. H.; Calamaras, T. D.; Miller, E. J.; Verbeuren, T. J.; Walsh, K.; Cohen, R. A.; Colucci, W. S. The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-induced Metabolic Heart Disease in Mice. Circulation. 2012, 125, 1757-1764, S1-6. [Epub Mar 2] PubMed PMID: 22388319; PubMed Central PMCID: PMC3354628.

Schildknecht, S.; Karreman, C.; Daiber, A.; Zhao, C.; Hamacher, J.; Perlman, D.; Jung, B.; van der Loo, B.; O’Connor, P.; Leist, M.; Ullrich, V.; Bachschmid, M. M. Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages. Antioxid. Redox Signal. 2012 [Epub Jun 25] PubMed PMID: 22578329.

Sargaeva, N. P.; Lin, C.; O’Connor, P. B. Differentiating N-terminal Aspartic and Isoaspartic Acid Residues in Peptides. Anal Chem. 2011, 83, 6675-6682. [Epub Aug 1] PMID: 21736361 PubMed Central PMCID: PMC3165085.

Sargaeva N. P.; Goloborodko, A. A.; O’Connor , P. B.; Moskovets, E.; Gorshkov, M. V. Sequence-specific Predictive Chromatography to Assist Mass Spectrometric Analysis of Asparagine Deamidation and Aspartate Isomerization in Peptides.Electrophoresis. 2011, 32, 1962-1969. PubMed PMID: 21557257.

 Sargaeva, N. P.; Lin, C.; O’Connor, P.B. Unusual Fragmentation of β-Linked Peptides by ExD Tandem Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22, 480-491. PubMed PMID: 21472566. 

Schulze, P. C.; Biolo, A.; Gopal, D.; Shahzad, K.; Balog, J.; Fish, M.; Siwik, D.; Colucci, W. S. Dynamics in Insulin Resistance and Plasma Levels of Adipokines in Patients with Acute Decompensated and Chronic Stable Heart Failure. J. Card. Fail. 2011, 17, 1004-1011. [Epub Oct 5] PubMed PMID: 22123363; PubMed Central PMCID: PMC3226951. 

Seta, F.; Bachschmid, M. Cyclooxygenase Pathway of the Arachidonate Cascade. eLS. 2012 John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0023401. Link

 Seward, R. J.; Drouin, E. E.; Steere, A. C.; Costello, C. E. Peptides presented by HLADR Molecules in Synovia of Patients with Rheumatoid Arthritis or Antibiotic-refractory Lyme Arthritis. Mol. Cell. Proteomics 2011 10(3):M110.002477. PubMed PMID: 21081667 PubMed Central PMCID: PMC3047150.

Théberge, R.; Infusini, G.; Tong, W.; McComb, M. E. Costello, C. E. Top-down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap: Potential for Mass Spectrometrybased Clinical Assays for Transthyretin and Hemoglobin. Int. J. Mass Spectrom., 2011, 300, 130-142. PubMed PMID: 21607198 PubMed Central PMCID: PMC3098445.

 Velagaleti, R. S.; Gona, P.; Sunström, J.; Larson, M. G.; Siwik, D.; Colucci, W. S.; Benjamin, E. J.; Vasan, R. S. Relations of Biomarkers of Extracellular Matrix Remodeling to Incident Cardiovascular Events and MortalityArterioscler. Thromb. Vasc. Biol. 2010, 30, 2283-2288. PubMed PMID: 20798380 PubMed Central PMCID: PMC2959140.

 Xu, S.; Jiang, B.; Hou, X.; Shi, C.; Bachschmid, M. M.; Zang, M.; Verbeuren, T. J.; Cohen, R. A. High-fat Diet Increases and the Polyphenol, S17834, Decreases Acetylation of the Sirtuin-1-dependent Lysine-382 on p53 and Apoptotic Signaling in Atherosclerotic Lesion-prone Aortic Endothelium of Normal Mice.” J. Cardiovasc. Pharmacol. 2011, 58, 263-271. PubMed PMID: 21654327; PubMed Central PMCID: PMC3168693.

 Xu, S.; Zhi, H.; Hou, X.; Cohen, R. A.; Jiang, B. IκBβ Attenuates Angiotensin II-induced Cardiovascular Inflammation and Fibrosis in Mice. Hypertension. 2011, 58, 310-316. [Epub Jun 6] PubMed PMID: 21646597; PubMed Central PMCID: PMC3141280.

Zee, R.; Yoo, C.; Pimentel, D.; Perlman, D.; Burgoyne,J.; Hou, X.; McComb, M. E. Costello, C. E.; Cohen, R. A.; Bachschmid, M. M. Redox Regulation of Sirtuin-1 by S-Glutathiolation. Antioxid. Redox Signal. 2010,13,1023-1032. PubMed PMID: 20392170.

Primary teaching affiliate
of BU School of Medicine