Modification of Cardiovascular Proteins by Metabolic Disease


A wide variety of academic faculty members combined to create the Cardiovascular Proteomics Center under the direction of Dr. Catherine E. Costello. CPC is a research institute studying oxidative stress using proteomics technologies. The faculty, true to the multi-disciplinary nature of cross-university alliances (which are spurring BUSM research grants in an era of restricted growth in biomedical research), represent the schools/departments/sections of Biochemistry, Physiology and Biophysics, Mass Spectrometry, Engineering, Bioinformatics, Cardiology, Epidemiology, and Medicine. In addition, CPC has many relationships and ongoing projects with researchers in the corporate sector.

Catherine E. Costello, Ph.D. Principal Investigator Mass Spectrometry, Proteomics Methods, Unfavorable Metabolic Syndromes
Richard A. Cohen, M.D. Co-PI, Leader for Vascular Biology Project Methods for Mouse Studies
Wilson S. Colucci, M.D. Co-PI, Leader for Clinical Project Metabolic Predictors of Diastolic Heart Failure
Mark E. McComb, Ph.D. Director, Cardiovascular Proteomics Core Laboratory Development and application of mass spectrometry (MS) and proteomics based technologies for the characterization of human disease
Vasan S. Ramachadran, M.D. Collaborator, BUSM, Framingham Heart Study Observations in the Offspring Cohort of the Framingham Heart Study
Christian Schöneich, Ph.D. Chair, Dept. of Pharmaceutical Chemistry, U Kansas Mechanisms of free radical reactions and protein stability
Primary teaching affiliate
of BU School of Medicine