Project 8:Lay summaries of CPC publications
In a recent development in project 8, researchers present evidence of the protective action of adiponectin by a newly-observed pathway and propose a new role for fat.
Spotlight, publication.
Zuccollo A, Shi C, Mastroianni R, Maitland KA, Weisbrod RM, Zang M, Xu S, Jiang B, Oliver-Krasinski JM, Cayatte AJ, Corda S, Lavielle G, Verbeuren TJ, Cohen RA. The Thromboxane A2 receptor antagonist, S18886, prevents enhanced atherogenesis caused by diabetes mellitus. Circulation 2005; 112: 3001-3008. Press release
di Bernardo D, Thompson MJ, Gardner TS, Chobot SE, Eastwood EL, Wojtovich AP, Elliott SJ, Schaus SE, and Collins JJ. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. Nature Biotechnology 2005. Lay summary and abstract Press release
Kuster GM, Pimentel DR, Adachi T, Ido Y, Brenner DA, Cohen RA, Liao R, Siwik DA, Colucci WS. Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation 2005. Lay summary and abstract Press release
Yang Y and Loscalzo J. S-nitrosoprotein formation and localization in endothelial cells. Proc Natl Acad Sci 2005; 102(1): 117-122. Lay summary and abstract
Sethuraman M, McComb ME, Huang H, Huang S, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag (ICAT) approach to redox proteomics: Identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures. J Proteome Research 2004; 3 (6): 1228- 1233. Lay summary and abstract
Adachi T, Weisbrod RM, Pimentel D, Ying J, Sharov VS, Schoneich C, Cohen RA. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. A mechanism targeted by oxidants in vascular disease. Nat Med 2004; 10: 1200-1207. Lay summary and abstract
