2008 OPTM
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Boston University School of Medicine’s NHLBI Cardiovascular Proteomics Center will host the third in a biennial series of symposia, October 1 through 3, 2008.
OPTM demands understanding and integration of physiology, pathology, biochemistry, and cell biology, as well as mastery of technologies of protein separation and mass spectrometry. Thus it represents a new fusion of these disciplines, harnessed to study reactive oxygen and nitrogen species in the cardiovascular system. This year we hope to increase the number of participating external scientists as well as the number of abstracts submitted. Our 2006 symposium engaged more than 140 researchers from the United States, United Kingdom, Uruguay, Germany, and France, and this year we hope to build significantly on that attendance. The research presentations provide a snapshot of this new field and demonstrated the tightening links between mass spectrometry and biology.
Highlights: The first two mornings of the conference will begin with presentations by keynote speakers, chosen with the advice of our Scientific Advisory Committee. The third and final day will feature Grand Rounds.
KEYNOTE SPEAKER: Pei Pei Ping, Ph.D. FAHA
Professor of Physiology and Medicine/Cardiology
University of California/Los Angeles
Dr. Ping is a molecular biologist and cell biologist, whose expertise is in the areas of signal transduction. Her research involves the investigation of the intracellular signaling events that underlie pathophysiology of cardiac myocytes associated with disease. The overall goal of the research is to elucidate the signal transduction cascades that underlie the response of the heart to ischemia and the processes that lead to heart failure. Ultimately, this research may lead to the identification of novel targets for pharmacologic or gene therapy to induce cardioprotection(ischemia) or to delay the progression of disease(heart failure). Dr. Ping’s Abstract.
KEYNOTE SPEAKER: Christine C. Winterbourn, Ph.D.
Professor of Pathology and Director, Free Radical Research Group
Otago University, Christchurch, New Zealand
Dr. Winterbourn received in 2004 the Distinguished Research Medal, the highest research honor conferred by the University of Otago, the first university in New Zealand (1869). Following her discovery that free radicals are generated by hemoglobin in association with the destruction of red blood cells and anemia, her work has led to the understanding that free radicals are constantly generated in cells and participate in normal function. She focuses on the development and application of specific biomarkers of oxidative stress, oxidant-sensitive cell proteins and links to redox-regulated signaling pathways, thiol reactions and cellular oxidant scavenging pathways. Dr. Winterbourn’s Abstract
KEYNOTE SPEAKER: Aimee Landar, Ph.D.
Assistant Professor of Pathology
School of Medicine
Birmingham, Alabama
Dr. Landar’s current research focuses on the use of proteomics approaches to determine the mechanisms of redox cell signaling under conditions of pathological stress. Redox cell signaling dysfunction impacts the pathogenesis of diseases including cancer, diabetes, atherosclerosis and ischemia-reperfusion injury. Her laboratory has coined the term “redox tone” to define the process by which ROS and RNS modify the function of proteins. Post-translational protein modifications under examination include nitrotryosine formation, protein thiol oxidation, and lipid-protein adducts. She will discuss these efforts as well as the modification of protein thiols by electrophilic lipids.
GRAND ROUNDS: Bradford C. Berk, M.D., Ph.D.
Senior Vice President for Health Sciences and CEO
University of Rochester Medical Center
Dr. Berk is a widely published cardiovascular specialist and internationally respected scientist, academic administrator, and educator-clinician who has successfully integrated research, teaching, and clinical programs. His research interests include the role of exidants in the cellular mechanisms underlying vascular and cardiac diseases, the role of stem cells in the pathogenesis of vascular disease, and abnormal vascular smooth muscle cell growth in diseased blood vessels.
Dr. Berk’s Abstract.
2008 Proteomics Methods Workshop
A new feature of the 2006 gathering, the methods workshop, will be offered again on Tuesday afternoon, September 30, for researchers interested in the state of the art. It includes introductory and advanced tutorials and hands-on proteomics science. The OPTM 2008 Methods Workshop curriculum covering the complex of mass spectral technologies that the Core Proteomics Laboratory is fashioning into one overall proteomics approach, two-thirds lecture and one-third wet lab. The cost, $75, is waived for students and trainees and attendance is limited to 45 in order to ensure the appropriate environment. Some of the technologies that will be covered:
- Electrospray Fourier Transform (FT) Mass Spectrometry (MS) to provide the mass of intact protein samples as well as top-down sequencing and initial peptide mapping;
- Matrix-Assisted Laser Desorption/Ionization Time of Flight MS for peptide mass mapping;
- MALDI FT MS for more accurate peptide mass measurement;
- Laboratory detection of Thiol modifications, iodoacetamide labeling, synthesis of biotin-tagged glutathione and other labels, S-Glutathiolation, and antibodies for oxidized thiols;
- New Proteome Lab Protein Fraction 2-Dimension (PF2D) protein fractionation methods to analyze protein abundance and detect protein modifications;
- Along with instruments purchased commercially, CPC researchers use hybrid FTMS instruments constructed in-house within BUSM’s Mass Spectrometry Resource, an NIH-NCRR Research Resource. This instrumentation also will be described in the tutorial.
OPTM SYMPOSIUM INFORMATION
Speakers and attendees are encouraged to arrive Tuesday. The program will begin each day at 8:30 am and finish at 5 pm Wednesday and Thursday and at 1 pm on Friday.
Audience: For this as for the previous conference, we hope to host an expert group of about 200 international participants for an in-depth look at developments in Cardiovascular Proteomics.
Travel Awards and Prizes: We are pleased that the NIH provided funds to support both this meeting and our previous meeting in 2006. This support, in addition to corporate support that we have solicited, allows us to provide travel awards for students and trainees. Those ten attendees submitting abstracts deemed most meritorious by the Scientific Advisory Committee will be awarded the amount of $750 each. Students, fellows, and trainees (faculty excluded) will be considered.
Funding: In addition to Cardiovascular Proteomics Center sponsorship, OPTM was sponsored by two NIH institutes, NHLBI and NIDDKD, the NHLBI’s Proteomics Initiative, Boston University School of Medicine, and corporate sponsors including Applied Biosystems/MDS SCIEX, Bruker-Daltonics, and Pressure BioSciences. Companies who support the conference will run display booths for the duration of the conference, located alongside the poster session in the Hiebert Lounge. Click in the banners on top and on the bottom to go to our sponsors’ websites. Funding for this conference was made possible (in part) by R13 HL78317 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Location: Registration and oral sessions will take place in a state-of-the-art auditorium located on the ground floor of 670 Albany Street (the building where Cardiovascular Proteomics Center labs and offices are located). On Wednesday and Thursday, the poster session will take place in the Hiebert Lounge, a large conference room in the main School of Medicine building across the street. Upon registration, registrants will receive a conference booklet with campus map identifying the buildings.
ONLINE REGISTRATION
Secure registration will remain open until Friday, September 26. All conference attendees–invited speakers, researchers, students, trainees, corporate sponsors–are requested to register in advance.
OPTM registration and abstract submission Hotel information 2008 OPTM Flyer Banquet at Amrhein’s Boston weather updates Corporate Sponsors
Reminder, all who wish to attend our meetings are expected to register on the secure site that is activated at the appropriate season. CPC investigators and trainees are expected to attend the meetings.
