Representative Publications
Representative Publications of the Research Activities of the Participating Faculty
Recent Publications (2008-2012)
Akey
Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW.
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure. 2011 Aug 10;19(8):1084-96.
Platonova O, Akey IV, Head JF, Akey CW.
Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry. 2011 Sep 20;50(37):8078-89. Epub 2011 Aug 24.
Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW.
Structure of an apoptosome-procaspase-9 CARD complex. Structure. 2010 May 12;18(5):571-83.
Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure. 2009 Apr 15;17(4):590-601.
Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW.
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure. 2008 Jul;16(7):1126-37.
Atkinson
The crystal structure of the C-terminal truncated apolipoprotein a-I sheds new light on amyloid formation by the N-terminal fragment. Biochemistry. 2012 Jan 10;51(1):10-8. Epub 2011 Dec 29.
Crystal structure of C-terminal truncated apolipoprotein A-I reveals the assembly of high density lipoprotein (HDL) by dimerization. J Biol Chem. 2011 Nov 4;286(44):38570-82. Epub 2011 Sep 13.
Gorshkova IN, Kypreos KE, Gantz DL, Zannis VI, Atkinson D.
Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia. Biochemistry. 2008 Nov 25;47(47):12644-54.
Jiang ZG, Liu Y, Hussain MM, Atkinson D, McKnight CJ.
Reconstituting initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system. J Mol Biol. 2008 Nov 28;383(5):1181-94. Epub 2008 Sep 12.
Wang L, Hua N, Atkinson D, Small DM.
The N-terminal (1-44) and C-terminal (198-243) peptides of apolipoprotein A-I behave differently at the triolein/water interface. Biochemistry. 2007 Oct 30;46(43):12140-51. Epub 2007 Oct 4.
Bolotina
Yang B, Gwozdz T, Dutko-Gwozdz J, Bolotina VM.
Orai1 and Ca2+-independent phospholipase A2 are required for store-operated IcatSOC current, Ca2+ entry and proliferation of primary vascular smooth muscle cell. Am J Physiol Cell Physiol. 2011 Nov 16. [Epub ahead of print]
Gwozdz T, Dutko-Gwozdz J, Zarayskiy V, Peter K, Bolotina VM.
How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol. 2008 Nov;295(5):C1133-40. Epub 2008 Sep 3.
Zarayskiy V, Monje F, Peter K, Csutora P, Khodorov BI, Bolotina VM.
Store-operated Orai1 and IP3 receptor-operated TRPC1 channel. Channels (Austin). 2007 Jul-Aug;1(4):246-52.
Orai, STIM1 and iPLA2beta: a view from a different perspective. J Physiol. 2008 Jul 1;586(13):3035-42. Epub 2008 May 22.
Chui
Akinsheye I, Solovieff N, Ngo D, Malek A, Sebastiani P, Steinberg MH, Chui DH.
Fetal hemoglobin in sickle cell anemia: Molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans. Am J Hematol. 2011 Oct 14. doi: 10.1002/ajh.22221. [Epub ahead of print]
Verhovsek M, So CC, O’Shea T, Gibney GT, Ma ES, Steinberg MH, Chui DH.
Is HbA(2) level a reliable diagnostic measurement for β-thalassemia trait in people with iron deficiency? Am J Hematol. 2012 Jan;87(1):114-6. doi: 10.1002/ajh.22188. Epub 2011 Oct 31.
Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA, Klings ES, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen S, Ha SY, Li CK, Chui DH, Baldwin CT, Steinberg MH.
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5′ olfactory receptor gene cluster. Blood. 2010 Mar 4;115(9):1815-22. Epub 2009 Dec 16.
Sickle cell disease caused by heterozygosity for Hb S and novel LCR deletion: Report of two patients. Am J Hematol. 2009 Sep;84(9):603-6.
Thornburg CD, Steinberg MH, Chui DH.
Hemoglobin SE disease in Maine, and severe thalassemia in New Hampshire. J Pediatr Hematol Oncol. 2009 Apr;31(4):307. No abstract available.
Cohen
Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2011 Nov 15. [Epub ahead of print]
Xu S, Jiang B, Hou X, Shi C, Bachschmid MM, Zang M, Verbeuren TJ, Cohen RA.
High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Sep;58(3):263-71.
Redox regulation of sirtuin-1 is mediated by S-glutathiolation. Antioxid Redox Signal. 2010 Apr 14. [Epub ahead of print]
Tong X, Evangelista A, Cohen RA.
Targeting the redox regulation of SERCA in vascular physiology and disease. Curr Opin Pharmacol. 2010 Apr;10(2):133-8. Epub 2010 Jan 4.
Tong X, Ying J, Pimentel DR, Trucillo M, Adachi T, Cohen RA.
High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol. 2008 Feb;44(2):361-9. Epub 2007 Nov 12.
Colucci
Schulze PC, Biolo A, Gopal D, Shahzad K, Balog J, Fish M, Siwik D, Colucci WS.
Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure. J Card Fail. 2011 Dec;17(12):1004-11. Epub 2011 Oct 5.
Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16;124(7):806-13. Epub 2011 Jul 25.
Lancel S, Qin F, Lennon SL, Zhang J, Tong X, Mazzini MJ, Kang YJ, Siwik DA, Cohen RA, Colucci WS.
Oxidative Posttranslational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in G{alpha}q-Overexpressing Mice. Circ Res. 2010 May 27. [Epub ahead of print]
Jeong MY, Walker JS, Brown RD, Moore RL, Vinson CS, Colucci WS, Long CS.
AFos inhibits phenylephrine-mediated contractile dysfunction by altering phospholamban phosphorylation. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1719-26. Epub 2010 Apr 2.
Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med. 2010 May 1;48(9):1182-7. Epub 2010 Feb 1.
Corkey
Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA.
Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov;1812(11):1393-402. Epub 2011 Jul 21.
Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, Bader JS, Wong GW, Corkey BE, Pandey A.
Temporal profiling of the secretome during adipogenesis in humans. J Proteome Res. 2010 Oct 1;9(10):5228-38.
Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE.
Respiration in Adipocytes is Inhibited by Reactive Oxygen Species. Obesity (Silver Spring). 2009 Dec 24. [Epub ahead of print]
Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE.
The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct;17(10):1856-60. Epub 2009 Jul 30.
Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct;58(10):2303-15. Epub 2009 Jul 6.
Costello
Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J.
Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2011 Nov 15. [Epub ahead of print]
Redox regulation of sirtuin-1 is mediated by S-glutathiolation. Antioxid Redox Signal. 2010 Apr 14. [Epub ahead of print]
Palaima E, Leymarie N, Stroud D, Mizanur RM, Hodgkin J, Gravato-Nobre MJ, Costello CE, Cipollo JF.
The Caenorhabditis elegans bus-2 mutant reveals a new class of O-glycans affecting bacterial resistance. J Biol Chem. 2010 Jun 4;285(23):17662-72. Epub 2010 Apr 12.
Li X, Lin C, Han L, Costello CE, O’Connor PB.
Charge remote fragmentation in electron capture and electron transfer dissociation. J Am Soc Mass Spectrom. 2010 Apr;21(4):646-56. Epub 2010 Jan 18.
Farber
Pulmonary hypertension: screening and evaluation in scleroderma. Curr Opin Rheumatol. 2011 Nov;23(6):536-44.
Walkey AJ, Fein D, Horbowicz KJ, Farber HW.
Differential response to intravenous prostacyclin analog therapy in patients with pulmonary arterial hypertension. Pulm Pharmacol Ther. 2011 Aug;24(4):421-5. Epub 2011 Jan 18.
Farber HW, Walkey AJ, O’Donnell MR.
Ethical issues associated with globalization of placebo-controlled in pulmonary arterial hypertension. J Heart Lung Transplant. 2010 Apr 22. [Epub ahead of print]
Hardy H, Backman ES, Farber HW.
Successful bosentan and nonnucleoside reverse transcriptase inhibitor-based therapy in a patient with acquired immunodeficiency syndrome and pulmonary arterial hypertension. Pharmacotherapy. 2010 Apr;30(4):139e-44e.
Early Pulmonary Embolectomy for Acute Pulmonary Embolus: J Card Surg. 2010 Feb 23. [Epub ahead of print]
Farrer
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2011 Nov 8. [Epub ahead of print]
Reitz C, Rogaeva E, Foroud T, Farrer LA.
Genetics and genomics of late-onset Alzheimer’s disease and its endophenotypes. Int J Alzheimers Dis. 2011;2011:284728. Epub 2011 May 23.
Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes. Neuropsychopharmacology. 2010 May 19. [Epub ahead of print]
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010 May 12;303(18):1832-40.
Alzheimer’s Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement. 2010 May;6(3):265-73.
Freedman
Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE.
Regulatory effects of TLR2 on megakaryocytic cell function. Blood. 2011 Jun 2;117(22):5963-74. Epub 2011 Mar 31.
Freedman JE, Vitseva O, Tanriverdi K.
The role of the blood transcriptome in innate inflammation and stroke. Ann N Y Acad Sci. 2010 Oct;1207:41-5. doi: 10.1111/j.1749-6632.2010.05731.x.
p38: signaling improved platelet storage? Blood. 2010 Mar 4;115(9):1665-6.
Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K.
A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr;8(4):817-27. Epub 2010 Jan 21.
The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes. Thromb Res. 2010 Mar;125(3):205-9. Epub 2009 Nov 27.
Gokce
Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):467-73. Epub 2011 Nov 17.
Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol. 2011 Jul 12;58(3):232-7.
Hamburg NM, Mott MM, Bigornia SJ, Duess MA, Kluge MA, Hess DT, Apovian CM, Vita JA, Gokce N.
Maladaptive enlargement of the brachial artery in severe obesity is reversed with weight loss. Vasc Med. 2010 Jun;15(3):215-22. Epub 2010 Apr 7.
Long-term successful weight loss improves vascular endothelial function in severely obese individuals. Obesity (Silver Spring). 2010 Apr;18(4):754-9. Epub 2010 Jan 7.
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem. 2010 Feb 26;285(9):6153-60. Epub 2009 Dec 22.
Hamilton
Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA.
Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May;51(5):914-22.
Vlahos R, Bozinovski S, Chan SP, Ivanov S, Linden A, Hamilton JA, Anderson GP.
Neutralizing GM-CSF Inhibits Cigarette Smoke-induced Lung Inflammation. Am J Respir Crit Care Med. 2010 Mar 4. [Epub ahead of print]
Cook AD, De Nardo CM, Braine EL, Turner AL, Vlahos R, Way KJ, Beckman SK, Lenzo JC, Hamilton JA.
Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement. Arthritis Res Ther. 2010 Mar 2;12(2):R37. [Epub ahead of print]
Kandror
Biogenesis and regulation of insulin-responsive vesicles containing GLUT4. Curr Opin Cell Biol. 2010 Apr 21. [Epub ahead of print]
Chakrabarti P, English T, Shi J, Smas CM, Kandror KV.
Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes. 2010 Apr;59(4):775-81. Epub 2010 Jan 12.
Jedrychowski MP, Gartner CA, Gygi SP, Zhou L, Herz J, Kandror KV, Pilch PF.
Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem. 2010 Jan 1;285(1):104-14. Epub 2009 Oct 28.
Leham
The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil. J Struct Biol. 2010 May;170(2):313-8. Epub 2010 Feb 1.
Galińska A, Hatch V, Craig R, Murphy AM, Van Eyk JE, Wang CL, Lehman W, Foster DB.
The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments. Circ Res. 2010 Mar 5;106(4):705-11. Epub 2009 Dec 24.
Li XE, Lehman W, Fischer S, Holmes KC.
Curvature variation along the tropomyosin molecule. J Struct Biol. 2010 May;170(2):307-12. Epub 2009 Dec 22.
Nugent
Spencer JL, Bernanke JA, Buczek-Thomas JA, Nugent MA.
A computational approach for deciphering the organization of glycosaminoglycans. PLoS One. 2010 Feb 23;5(2):e9389.
Vora SR, Palamakumbura AH, Mitsi M, Guo Y, Pischon N, Nugent MA, Trackman PC.
Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts. J Biol Chem. 2010 Mar 5;285(10):7384-93. Epub 2010 Jan 4.
Smith EM, Mitsi M, Nugent MA, Symes K.
PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21683-8. Epub 2009 Dec 4.
Pilch
Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA.
Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May;51(5):914-22.
Jedrychowski MP, Gartner CA, Gygi SP, Zhou L, Herz J, Kandror KV, Pilch PF.
Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem. 2010 Jan 1;285(1):104-14. Epub 2009 Oct 28.
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009 Dec;58(12):2788-96. Epub 2009 Sep 9.
Ravid
Eliades A, Papadantonakis N, Ravid K.
New roles for cyclin E in megakaryocytic polyploidization. J Biol Chem. 2010 Apr 14. [Epub ahead of print]
Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K.
A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr;8(4):817-27. Epub 2010 Jan 21.
Genzen JR, Yang D, Ravid K, Bordey A.
Activation of adenosine A2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells. Cerebrospinal Fluid Res. 2009 Nov 18;6:15.
Ruderman
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 4;464(7285):121-5.
Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y.
AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E751-60. Epub 2010 Jan 26. Review.
Ritov VB, Menshikova EV, Azuma K, Wood RJ, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE.
Deficiency of Electron Transport Chain in Human Skeletal Muscle Mitochondria in Type 2 Diabetes Mellitus and Obesity. Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]
Sam
Serial troponin-I measurement as a diagnostic and therapeutic tool in chronic myocarditis. J Heart Lung Transplant. 2010 Apr 21. [Epub ahead of print] No abstract available.
Biolo A, Shibata R, Ouchi N, Kihara S, Sonoda M, Walsh K, Sam F.
Determinants of adiponectin levels in patients with chronic systolic heart failure. Am J Cardiol. 2010 Apr 15;105(8):1147-52. Epub 2010 Feb 20.
What can adiponectin say about left ventricular function? Heart. 2010 Mar;96(5):331-2. Epub 2009 Nov 23. No abstract available.
Schreiber
Sullivan CP, Seidl SE, Rich CB, Raymondjean M, Schreiber BM.
Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem. 2010 Jan 1;285(1):565-75. Epub 2009 Oct 22.
Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K.
The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):792-6. Epub 2008 Jan 9.
Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun. 2008 Feb 1;366(1):156-61. Epub 2007 Dec 3.
Small
The adsorption of biological peptides and proteins at the oil/water interface. A potentially important but largely unexplored field. J Lipid Res. 2009 Apr;50 Suppl:S329-34. Epub 2008 Nov 21.
Role of ABC transporters in secretion of cholesterol from liver into bile. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):4-6. Epub 2002 Dec 30. No abstract available.
Duggan A, Paolucci M, Tercyak A, Gigliotti M, Small D, Callard I.
Seasonal variation in plasma lipids, lipoproteins, apolipoprotein A-I and vitellogenin in the freshwater turtle, Chrysemys picta. Comp Biochem Physiol A Mol Integr Physiol. 2001 Sep;130(2):253-69.
Smith
Wu X, Kong X, Luchsinger L, Smith BD, Xu Y.
Regulating the activity of class II transactivator by posttranslational modifications: exploring the possibilities. Mol Cell Biol. 2009 Nov;29(21):5639-44. Epub 2009 Aug 31.
St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K.
TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008 Oct 24;375(3):292-6. Epub 2008 Jul 21.
Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling. J Biol Chem. 2008 May 23;283(21):14213-20. Epub 2008 Mar 21.
Vita
Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease? Can J Cardiol. 2010 Mar;26 Suppl A:45A-50A. Review.
Milbury PE, Vita JA, Blumberg JB.
Anthocyanins are bioavailable in humans following an acute dose of cranberry juice. J Nutr. 2010 Jun;140(6):1099-104. Epub 2010 Apr 7.
Hamburg NM, Mott MM, Bigornia SJ, Duess MA, Kluge MA, Hess DT, Apovian CM, Vita JA, Gokce N.
Maladaptive enlargement of the brachial artery in severe obesity is reversed with weight loss. Vasc Med. 2010 Jun;15(3):215-22. Epub 2010 Apr 7.
Walsh
Androgen Receptor Counteracts Doxorubicin-Induced Cardiotoxicity in Male Mice. Mol Endocrinol. 2010 May 25. [Epub ahead of print]
Ohashi K, Ouchi N, Higuchi A, Shaw RJ, Walsh K.
LKB1-deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem. 2010 May 19. [Epub ahead of print]
Papanicolaou KN, Streicher JM, Ishikawa TO, Herschman H, Wang Y, Walsh K.
Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. J Mol Cell Cardiol. 2010 Apr 24. [Epub ahead of print]
Zannis
Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ, Zannis VI.
MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res. 2010 Jun;51(6):1513-23. Epub 2010 Feb 2.
Gorshkova IN, Kypreos KE, Gantz DL, Zannis VI, Atkinson D.
Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia. Biochemistry. 2008 Nov 25;47(47):12644-54.
Zannis VI, Koukos G, Drosatos K, Vezeridis A, Zanni EE, Kypreos KE, Chroni A.
Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models. Ann Med. 2008 Feb;40 Suppl 1:14-28. Review.
Recent Publications (2007-2008)
Atkinson
Hongli L.Zhu and D. Atkinson.
Conformation and Lipid Binding of a C-Terminal(198-243) Peptide of Human Apolipoprotein A-1. Biochemistry. 2007. 46(6): 1624-1634. PMID: 17279626
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Bolotina
Zarayskiy V., Monje F., Peter K., Csutora P., Khodorov B.I., Bolotina V.M.
Store-operated Orai1 and IP3 receptor-operated TRPC1: separation of Siamese twins.
Channels. 2007. 1(4):246-252. PMID: 18711860
Park K., Trucillo M., Serban D.N., Cohen R.A., Bolotina V.M.
The role of iPLA2 and store-operated channels in agonist-induced constriction of small resistant vessels.
Am. J. Physiol Heart Circ Physiol. 2008. Mar;294(3):H1183-7. PMID: 18156193
Csutora P., Peter K., Kilic H., Park K., Zarayskiy V., Gwozdz T., and Bolotina V.M.
Novel role of STIM1 as a trigger for Calcium Influx Factor production. calcium influx factor (CIF) production.
J Biol Chem. 2008. 283:14524-14531. PMID: 18337241
Smani T., Patel T., Bolotina V.M.
Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs.
Am J Physiol Cell Physiol.. 2008. 294(6): C1499-508. PMID: 18434622
Gwozdz T., Dutko-Gwozdz J., Zarayskiy V., and Bolotina V.M.
How strict is the correlation between STIM1 and Orai1 expression, puncta formation and ICRAC activation?
Am J Physiol Cell Physiol.. 2008 Sep 3. [Epub ahead of print] PMID: 18768920
Cohen
Ying J, Tong XY, Pimental DR, Weisbrod RM, Trucillo MP, Adachi T, Cohen RA.
Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide.
Arterioscler Thromb Vasc Biol. 2007. Apr;27(4):783-90. PMID: 17234728
Tong XY, Ying J, Pimentel DR, Trucillo M, Adachi T, Cohen RA. High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration.
J. Mol. Cell Cardiol. 2008. Feb;44(2):361-9. PMID: 18164028
Colucci
Wang TJ, Larson MG, Benjamin EJ, Siwik DA, Safa R, Guo CY, Corey D, Sundstrom J, Sawyer DB, Colucci WS, Vasan RS.
Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community.
Am Heart J. 2007. Aug;154(2):291-7. PMID: 17643579
Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, Sam F, Ouchi N, Walsh K.
Adiponectin protects against the development of systolic dysfunction following myocardial infarction.
J Mol Cell Cardiol. 2007. Jun;42(6):1065-74. PMID: 17499764
Givertz MM, Andreou C, Conrad CH, Colucci WS.
Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships.
Circulation. 2007. Mar 13;115(10):1218-24. PMID: 17339544
Corkey
Heart, E., Yaney, G. C., Corkey, R. F., Schultz, V., Luc, E., Liu, L., Deeney, J. T., Shirihai, O., Tornheim, K., Smith, P.J.S. and Corkey, B. E.
Ca2+, NAD(P)H and Membrane Potential Changes in Pancreatic ß-Cells by Methyl-Succinate: Comparison with Glucose.
Biochem. J. 2007. 403:197-205 PMID: 17181533
Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W, Thomou, T., Han, J., Wang, T., Wang, S., Cartwright, A., Hegardt, F., Corkey, B. E. and Kirkland, J. L.
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
Am. J. Physiol. 2007. 292:E1041-1051 PMID: 17148751
Pi, J., Bai, Y., Zhang, Q., Wong, V., Floering, L. M., Daniel, K., Reece, J. M., Deeney, J. T., Andersen, M. E., Corkey, B. E. and Collins, S.
Reactive oxygen species as putative signals in glucose-stimulated insulin secretion: Relationship to oxidative stress.
Diabetes. 2007. 56:1783-1791 PMID: 17400930
Han J. R., Deng B., Sun J., Chen C. G., Corkey B. E., Kirkland J.L., Ma J. and Guo W.
Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects.
Metabolism. 2007. 56:985-991 PMID: 17570262
Guo, W., Bigornia, S., Xie, W., McDonnell, M., Clemente, K., Leizerman, I, Pirtskhalava, T., Kirkland, J. L., Gokce, N., Corkey, B. E., Sullivan, C. L. and Apovian, C.
A new scanning electron microscopic method for determination of adipocyte size in human fat tissue: correlations with weight loss and fat depot origin.
Obesity. 2007. 15:1657-1665 PMID: 17636083
Deeney, J. T., Branstrom, R., Corkey, B. E., Larsson, O. and Berggren, P.-O.
3H-Serotonin as a Marker of Oscillatory Insulin secretion in Clonal ß-Cells (INS-1)
FEBS Lett. 2007. 581:4080-4084 PMID: 17686476
Wikstrom, J. D., Katzman, S. M., Mohamed, H., Twig, G., Graf, S. A., Elorza, A., Heart, E., Corkey, B. E., de Vargas, L. M., Danial, N. N., Collins, S., Shirihai, O. S.
ß-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.
Diabetes. 2007. 56:2569-2578 PMID: 17686943
Song, D H, Getty-Kaushik, L, Tseng, E, Simon, J, Corkey, BE, and Wolfe M.
Glucose-dependent insulinotropic polypeptide (GIP) activates Akt and enhances glucose uptake in adipocytes.
Gastroent. 2007. Dec;133(6):1796-805. PMID: 18054552
Trus, M., Corkey, R. F., Nesher, R., Richard, A. M., Deeney, J. T., Corkey, B. E. and Atlas, D.
The L-Type voltage-gated Ca2+-channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic ß-cells.
Biochemistry. 2007. Dec 18;46(50):14461-7. PMID: 18027971
Twig, G., Wikstrom, J., Molina, A., Elorza, A., Haigh, S., Katz, S., Walzer, G., Mohamed, H., Deeney, J.T., Corkey, B. E. and Shirihai, O. S.
Fission and Selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008. Jan 23;27(2):433-46. PMID: 18200046
Costello
Pilch, P. F.; Souto, R. P.; Liu, L.; Jedrychowski, M. P.; Berg, E. A.; Costello, C. E.; Gygi, S. P.
Cellular Spelunking: Exploring Adipocyte Caveolae.
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Zhao, C.; Xie, B.; Chan, S.-Y.; Costello, C. E.; O’Connor, P. B.
Collisionally Activated Dissociation and Electron Capture Dissociation Provide Complementary Structural Information for Permethylated Oligosaccharides.
J. Am. Soc. Mass Spectrom. 2008. T19,TT138-150T. PMID: 18063385
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Comparative Glycomics of Connective Tissue Glycosaminoglycans.
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Lim, C. C.;, Yang, H.; Yang, M.; Berg, E. A.; Pimentel, D. R.; Shi, J.; Wang, C.-K.; Gwathmey, J. K.; Costello, C. E.; Huo, S.; Liao, R.
A Novel Mutant Cardiac Troponin C Disrupts Molecular Motions Critical for Calcium Binding Affinity and Cardiomyocyte Contractility.
Biophys. J. 2008. 94, 3577-3589. PMID: 18212018
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Human Proteinpedia: A Portal for Sharing and Integration of Human Protein Data.
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Kingsbury, J. S.; Klimtchuk,P PE. S.; Laue, T. M.; Théberge, R.; Costello, C. E.; Connors, L. H.
The Modulation of Transthyretin Tetramer Stability by Cysteine-10 Adducts and the Drug Diflunisal: Direct Analysis by Fluorescence-detected Analytical Ultracentrifugation.
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Unique Asn-linked Oligosaccharides of the Human Pathogen Entamoeba histolytica.
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Lavatelli, F.; Perlman, D. H.; Spencer, B.; Prokaeva, T.; McComb, M. E.; Théberge, R.; Connors, L. H.; Bellotti, V.; Seldin, D. C.; Merlini, G.; Skinner, M.; Costello, C. E.
Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol. Cell. Proteomics 2008. 7, 1570-1583. PMID: 18474516
Singh, B. N.; Hayes, G. R.; Lucas, J. J.; Sommer, S.; Viseux, N.; Mirgorodskaya, E.; Trifonova, R. T.;
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Structural Details and Composition of Trichomonas vaginalis Lipophosphoglycan in Relevance to the Epithelial Immune Function.
Glycoconj. J., 2008,. [Epub July 6] PMID: 18604640
Kilcoyne, M.; Shah, M.; Gerlach, J. Q.; Bhavanandan, V.; Nagaraj, V.; Smith, A. D.; Fujiyama, K.; Sommer, U.; Costello, C. E.; Olszewski, N.; Joshi, L.
O-Glycosylation of Protein Subpopulations in Alcohol-extracted Rice Proteins.
J. Plant Physiol. 2008. [Epub Jul 17] PMID: 18639953
Farber
Odhuambo A, Perlman D, Huang H, Costello C, Farber HW, Steinberg MH, McComb M, Klings ES.
Identification of oxidative post-translational modifications on plasma albumin in patients with pulmonary hypertension of sickle cell anemia.
Rapid Comm in Mass Spectrom 2007. 21:2195-2203. PMID: 17569101
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On the importance of plasmalogen status in stimulated arachidonic acid release in the macrophage cell line RAW 264.7.
Biochim Biophys Acta. 2008. 1781:213-9. PMID: 18328831
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Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: Clinical characteristics and association with soluble adhesion molecule expression.
Am J Hematol. 2008. Am J Hematol. 2008 Jul;83(7):547-53. PMID: 18383329
Farrer
Rogaeva E, Meng Y, Lee JH, … (34 additional co-authors) …, Mayeux R, Farrer LA, St George-Hyslop P.
The sortilin-related receptor SORL1 is functionally and genetically associated with Alzheimer’s disease.
Nat Genet. 2007. 39:168-177. PMID: 17220890
Nolan V, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C, Mahabir RN, Homan EP, Wyszynski DF, Fabry ME, Nagel RL, Farrer LA, Steinberg MH.
Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.
Am J Hematol. 2007. 82:179-84. PMID: 17034027
Sebastiani P, Nolan V, Baldwin CT, Abad-Grau MM, Wang L, Adewoye H, McMahon L, Farrer LA, Taylor JG 4th, Kato GJ, Gladwin MT, Steinberg MH.
A network model to predict the risk of death in sickle cell disease.
Blood. 2007. 110: 2727-2735. PMID: 17600133
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ß-globin gene cluster polymorphisms are associated with severity of Hb E / ß0 thalassemia.
Clin Genet. 2007. 72:497-505. PMID: 17894837
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Substance dependence whole genome association study in two distinct American populations. Hum Genet. 2008. 123:495-506. PMID: 18438686
T.Cuenco K, Lunetta K, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St. George-Hyslop P, Chui H, DeCarli C, Farrer LA.
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Arch Neurol. 2008. In press.
Freedman
Chakrabarti S, Blair P, Freedman JE.
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Jnl Biol Chem. 2007. 282:18307-18317. PMID: 17459878
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Heritability, Platelet Function, and Aspirin: A Link Established but Cause Unknown.
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Translational Therapeutics at the Platelet Vascular Interface. Oxidative Stress and Platelets. Arterioscler Thromb Vasc Biol. 2008. Mar;28(3):s11-6. PMID: 18174453
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Shaik Y.B., S. Grogan, M. Davey, S. Sebastian, S. Goswami, B. Szmigielski, and C.A. Genco. Expression of the iron-activated nspA and secY genes in Neisseria meningitidis Group B by Fur-dependent and -independent mechanisms.
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Porphyromonas gingivalis mediated periodontal disease and atherosclerosis: Disparate disease with commonalities in pathogenesis through TLRs.
Current Pharmaceutical Design. 2007. 13: 3665-3675. PMID: 18220804
Liu, X., T. Ukai, H. Yumoto, M. Davey, F.C. Gibson, and C.A. Genco.
TLR2 plays a critical role in the atherosclerotic inflammatory response in apolipoprotein E- deficient mice that is independent of dietary lipids.
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Davey, M., X. Liu, T. Ukai, V. Jain, C. Gudino, F.C. Gibson III, D. Golenbock, A. Visintin, and C.A. Genco.
Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs. J. Immunol. 2008. 180: 2187-2195. PMID: 18250425
Gibson III, F.C., T. Ukai, and C.A. Genco.
Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis.
Frontiers in Bioscience. 2008. 13: 2041-2059. PMID: 17981690
Ukai, T. H. Yumoto, T. Miyamoto, F.C. Gibson III, and C.A. Genco.
Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2 dependent tumor necrosis factor-alpha production.
Infect. Immun. 2008. 6: 812-819. PMID: 17998311
Isabella, V., L. F. Wright, K. Barth, J.M. Spence, S. Grogan, C.A. Genco, and V.L. Clark.
cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae.
Microbiology. 2008. 154: 226-239. PMID: 18174141
Agarwal, S., S. Sebastian, B. Szmigielski, P. A. Rice, and C. A. Genco.
Expression of the gonococcal global regulatory Fur, and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women.
J. Bacteriol. 2008. 190:3129-3139. (PMC2347397)
Hamilton
Qiao Y, Farber A, Semaan E, Hamilton JA
Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration.
Circulation. 2008 Sep 2;118(10):e147-8. PMID: 18765382
Hamilton J.A. and Deckelbaum R. D.
The crystal structure of CETP: new hope for raising HDL to decrease risk if cardiovascular disease?
Nature Structural and Molecular Biology, 2007 Feb;14 (2):95-7. PMID: 17277799
Duncanson WJ, Figa MA, Hallock K, Zalipsky S, Hamilton JA, Wong JY.
Targeted binding of PLA microparticles with lipid-PEG-tethered ligands.
Biomaterials. 2007 Nov;28(33):4991-9. PMID: 17707503
Simard JR, Kamp F, Hamilton JA.
Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes.
Biophys J. 2008 Jun;94(11):4493-503. PMID: 18296488
Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K.
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.
Cell Metab. 2008 Feb;7(2):159-72. PMID: 18249175
Kandror
Shi, J. and Kandror, K.V.
The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin responsive Glut4-containing vesicles.
J.Biol.Chem. 2007. v. 282(12):9008-16. PMID: 17220298
Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW.
An ACAP1-containing clathrin coat complex for endocytic recycling.
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J Biol Chem. 2008. Aug 18. [Epub ahead of print] PMID: 18713752
Lehman
Kalomoira, S., A. T. Coulton, W. Lehman, M. A. Geeves & D. P. Mulvihill.
Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe.
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Greenberg, M. J., C.-L. Wang, W. Lehman & J. R. Moore.
Modulation of actin mechanics by caldesmon and tropomyosin.
Cell Motil. Cytoskeleton. 2008. 65:156-164. PMID: 18000881
Lehman, W. & Craig, R.
Tropomyosin and the Steric Mechanism of Muscle Regulation. In Tropomyosin (ed. P. Gunning) Landes BioScience (Austin, TX). 2008.
Maytum, R., M. Konrad, V. Hatch, W. Lehman & M. A. Geeves.
Ultra short yeast tropomyosins show novel myosin regulation.
J. Biol. Chem. 2008. 283:1902-1910. PMID: 18006493
Galińska-Rakoczy, A., P. Engel, C. Xu, H.-S. Jung, R. Craig, L.S. Tobacman & W. Lehman. Structural basis for the regulation of muscle contraction by troponin and tropomyosin.
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Morgan
Li Y, Gallant C, Malek S, Morgan KG.
Focal adhesion signaling is required for myometrial ERK activation and contractile phenotype switch before labor.
J Cell Biochem. 2007. 100(1):129-40. PMID: 16888778
Ahn DS, Choi SK, Kim YH, Cho, YE, Shin HM, Morgan KG, Lee YH.
Enhanced stretch-induced myogenic tone in the basilar artery of spontaneously hypertensive rats.
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Munevar S, Gangopadhyay SS, Gallant C, Colombo B, Sellkee FW, Morgan KG.
CaMKII T287 and T305 regulate history-dependent increases in alpha agonist-induced vascular tone.
JCMM. 2008. 12:219-26. PMID: 18088385
Gangopadhyay SS, Gallant C, Sundberg EJ, Lane WS, Morgan KG.
Regulation of CaM kinase II by a small CTD phosphatase
Biochemical J. 2008. Jun 15;412(3):507-16. PMID: 1833898
Wu X, Morgan KG, Jones CJ, Tribe RM, Taggart MJ.
Myometrial mechanoadaptation during pregnancy: implications for smooth muscle plasticity and remodelling.
JCMM. 2008. Mar 17. [Epub ahead of print] PMID: 1836383
Nugent
Suki, B., Majumdar, A., Nugent, M.A., and Bates, J.H.T.
In silico Modeling of Interstitial Lung Mechanics: Implications for Disease Development and Repair.
Drug Discovery Today: Disease Models. 2007. 4, 139-145. PMID: 18709177
Fannon, M, Forsten-Williams, K, Nugent, MA, Gregory, KJ, Chu, CL, Goerges-Wildt, AL, Panigrahy, D, Kaipainen, A, Lapp, C, Shing, Y.
Sucrose Octasulfate Modulates Fibroblast Growth Factor-2 Binding, Transport and Activity: Potential for Regulation of Tumor Growth.
J. Cell. Physiol. 2008. 215, 434-441. PMID: 18163458
Yang, S, Nugent, MA, and Panchenko, MP.
EGF Antagonizes TGF-beta Induced Tropoelastin Expression in Lung Fibroblasts via Stabilization of Smad Corepressor TGIF.
Am J Physiol Lung Cell Mol Physiol. 2008. 295(1):L143-51. PMID: 18441095
Buczek-Thomas, J., Hsia, E., Rich, C.B, Foster, JA, and Nugent, M.A.
Inhibition of histone acetyltransferase by heparin and heparan sulfate.
J. Cell. Biochem. 2008. 105(1):108-20. PMID: 18459114
Pilch
Pilch PF, Souto RP, Liu L, Jedrychowski MP, Berg EA, Costello CE, Gygi SP.
Cellular spelunking: exploring adipocyte caveolae.
J Lipid Res. 2007. 48, 2103-2111. PMID: 17496267
Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF.
Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle.
Mol Endocrinol. 2007. 21, 2152-2163. PMID: 17550977
Coderre L, Vallega GA, Pilch PF, Chipkin SR.
Regulation of glycogen concentration and glycogen synthase activity in skeletal muscle of insulin-resistant rats.
Arch Biochem Biophys. 2007. 464:144-150. PMID: 17509520
Saito, T., Jones, C.C., Huang, S., Czech, M.P. and Pilch, P.F.
The interaction of AKT with APPL1 is required for insulin-stimulated Glut4 translocation.
J Biol Chem. 2007. 282, 32280-32287. PMID: 17848569
Liu L and Pilch P.F.
A critical role of cavin (PTRF) in caveolae formation and organization.
J Biol Chem. 2008. 283, 4314-4322. PMID: 18056712
Pilch P.F.
The mass action hypothesis: formation of Glut4 storage vesicles, a tissue-specific, regulated exocytic compartment.
Acta Physiol (Oxf). 2008. 192:89-101. PMID: 18171432
Ravid
Yang, D., Koupenova, M., McCrann, D.J., Kopeikina, K.J., Kagan, H., Schreiber, B.M., and Ravid, K.
The A2b adenosine receptor protects against vascular injury.
PNAS. 2008. 05(2):792-796. PMID: 18184815
Grenz, A., Osswald, H., Eckle, T. Yang, D., Zhang, H., Z. V., Tran, Klingel, K., Ravid, K., and Eltzschig, H. K.
The reno-vascular A2B adenosine receptor protects the kidney from ischemia.
PLoS Medicine. 2008. Jun 24;5(6):e137. PMID: 18578565
Xu, Y., Ravid, K. and Smith, B.D.
Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling.
J Biol Chem. 2008. 283(21):14213-20. PMID: 18359773
Papadantonakis, N, Makitalo, M, McCrann, DJ, Liu, K., Nguyen, HG, Martin, G., Patel-Hett, G., Italiano, JE, and Ravid, K.
Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells.
Cell Cycle. 2008. Aug;7(15):2352-6. PMID: 18677109
Lucero, H.L., Ravid, K., Grimsby, J.L., Rich, C.B., Dicamillo, S.J., Maki, J.M., Myllyharju, J., and Kagan, H.M.
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells.
J. Biol Chem. 2008. (in press) PMID: 18586678
St.Hilaire, C., Koupenova, M., Carroll, S.H., Smith, B.D., and Ravid, K.
TNF-alpha upregulates the A(2B) adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008. Jul 19. [Epub ahead of print] PMID: 18647598
McCrann, D.J., Yezefski, T., Nguyen, H.G., Liu, H., Wen, Q., Crispino, J.D., and Ravid, K. Survivin overexpression in transgenic mice does not alter megakaryocyte ploidy status nor interfere with erythroid/megakaryocytic lineage development.
Blood. 2008. 111(8):4092-4095. PMID: 18245663
St. Hilaire, C., Yang, D., Schreiber, B.M., and Ravid, K.
B-Myb regulates the A2b adenosine receptor in vascular smooth muscle cells.
J. Cell. Biochem. 2008. 103:1962-1974. PMID: 17979185
McCrann, D.J., Nguyen, H.G., Jones, M.R., and Ravid, K.
Vascular smooth muscle cell polyploidy: An adaptive or maladaptive response?
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Hurtado, P.A., Vora, S., SUme, S.S., Yang, D., Guo, Y., Schreiber, B.M., Ravid, K., and Trackman, P.C.
Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.
Biochem Biophys Res Commun. 2008. 366(1):156-161. PMID: 18060869
Yang, D., McCrann, DJ, Nguyen, H.G., St. Hilaire, C. DePinho R.A., Jones, M.R., and Ravid, K.
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence.
Aging Cell. 2007. 6:257-260. PMID: 17291294
Ruderman
Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA.
Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers.
Arterioscler Thromb Vasc Biol. 2007. Dec;27(12):2650-6. PMID: 17932315
Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.
J Biol Chem. 2008 Jun 13;283(24):16514-24. PMID: 18390901
Schreiber
Xu, Y., McDonald, J., Perloff, E., Butticè, G., Schreiber, B. M. and Smith, B. D.
Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice.
Mol. Immunol. 2007. 44:1720-1732. PMID: 16982097
St. Hilaire, C., Yang, D., Schreiber, B. M., and Ravid, K.
B-Myb regulates the A2B adenosine receptor in vascular smooth muscle cells.
J. Cell. Biochem. 2008. 103:1962-74. PMID: 17979185
Hurtado, P. A., Vora, S., Sume, S. S., Yang, D., Hilaire, C. S., Guo, Y., Palamakumbura, A. H., Schreiber, B. M., Ravid, K and Trackman, P. C.
Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.
Biochem, Biophys, Res, Commun. 2008. 366:156-61. PMID: 18060869
Yang, D., Koupenova, M., McCrann, D. J., Kopeikina, K. J., Kagan, H. M., Schreiber, B. M. and Ravid, K.
The A2b adenosine receptor protects against vascular injury.
Proc. Natl. Acad. Sci. USA. 2008. 105:792-6. PMID: 18184815
Small
Wang L, Hua N, Atkinson D, Small DM.
The N-terminal (1-44) and C-terminal (198-243) peptides of apolipoprotein A-I behave differently at the triolein/water interface.
Biochemistry. 2007. 46(43):12140-51. PMID: 17915945
Bagurdes LA, Mesulam MM, Gitelman DR, Weintraub S, Small DM.
Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment.
Neuropsychologia. 2008. 46(12):2943-8. PMID: 18602410
Smith
Xu Y, McDonald J, Perloff E, Buttice G, Schreiber BM, Smith BD.
Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice.
Mol Immunol. 2007. 44, 1720-32. PMID: 16982097
Xu Y, Farmer SR, Smith BD.
PPARgamma interacts with CIITA/RFX5 complex to repress type I collagen gene expression.
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Xu, Y, Harton J, and Smith B.D.
CIITA mediates IFN-g repression of collagen transcription through phosphorylation dependent interactions with co-repressor molecules.
J. Biol. Chem. 2008. Jan 18;283(3):1243-56. Epub 2007 Nov 8. PMID: 17991736
Xu ,Y., Ravid, K., and Smith B.D.
Major histocompatibility class II transactivator (CIITA) expression in smooth muscle cells from A2b adenosine receptor knockout mice: crosstalk between the adenosine and IFN-gamma signaling.
J. Biol. Chem. 2008. May 23;283(21):14213-20. PMID: 18359773
Vita
Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF, Jr, Vita JA.
Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers.
Arterioscl Thromb Vasc Biol. 2007. 27:2650-2656. PMID: 17932315
Vasan RS, Larson MG, Aragam J, Wang TJ, Mitchell GF, Kathiresan S, Newton-Cheh C, Vita JA, Keyes MJ, O’Donnell CJ, Levy D, Benjamin EJ.
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
BMC Medical Genetics 2007. 8 (Suppl 1):S2
Hamburg NM, Keyes MJ, Larson MG, Vasan RS, Schnabel R, Pryde MM, Mitchell GF, Sheffy J, Vita JA, Benjamin EJ.
Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study.
Circulation. 2008 May 13;117(19):2467-74. PMID: 18458169
Schnabel R, Larson MG, Dupuis J, Lunetta KL, Lipinska I, Meigs JB, Yin X, Rong J, Vita JA, Newton-Cheh C, Levy D, Keaney JF Jr, Vasan RS, Mitchell GF, Benjamin EJ.
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.
Hypertension. 2008. Jun;51(6):1651-7. PMID: 18426996
Walsh
Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K.
Fast/glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.
Cell Metab. 2008. 7:159-172. Accompanied by editorial. PMID: 18249175
Papanicolaou KN, Izumiya Y, Walsh K.
Forkhead transcription factors and cardiovascular biology.
Circ Res. 2008. 102:16-31. PMID: 18174472
Lee HY, You HJ, Won JY, Youn SW, Cho HJ, Park KW, Seo JS, Park YB, Walsh K, Oh BH, Kim HS.
Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases.
Arterioscler Thromb Vasc Biol. 2008. 28:302-308. PMID: 18063811
Ikeda Y, Ohashi K, Shibata R, Pimentel DR, Kihara S, Ouchi N, Walsh K.
Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes.
FEBS Lett. 2008. 582:1147-1150. PMID: 18339320
Mogi M, Walsh K, Iwai M, Horiuchi M.
Akt-FOXO3a signaling affects human endothelial progenitor cell differentiation.
Hypertens. Res. 2008. 31:153-159. PMID: 18360030
Shibata R, Skurk C, Ouchi N, Galasso G, Kondo K, Ohashi T, Shimano M, Kihara S, Murohara T, Walsh K.
Adiponectin promotes endothelial progenitor cell number and function.
FEBS Lett. 2008. 582:1607-1612. PMID: 18423403
Summer R, Little F, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K.
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin deficient mice.
Am J Physiol Lung Cell Mol Physiol. 2008. 294(6):L1035-42. PMID: 18326826
Aprahamian T, Takemura Y, Goukassian D, Walsh K.
Aging is associated with diminished apoptotic cell clearance in vivo.
Clin Exp Immunol. 2008. 152:448-55. PMID: 18422728
Shibata R, Numaguchi Y, Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N, Murohara T.
Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction.
Am. J. Cardio. 2008. 01:1712-5. PMID: 18549845
Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K.
Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart.
Circulation. 2008. 117:3099-108. PMID: 18519848
Schiekofer S, Belisle K, Galasso G, Schneider J, Burster T, Schmitz G, Boehm BO, Walsh K.
Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells.
Angiogenesis. 2008. 11:289-99. PMID: 18491207
Wong
S. Koester, J.B. Leach, T. Pfohl, and J.Y. Wong.
Visualization of flow-aligned type I collagen self-assembly in tunable pH-gradients.
Langmuir. 2007. 23: 357-359. PMID: 17209575
J.B. Leach, X.Q. Brown, J.G. Jacot, P.A. DiMilla, and J.Y. Wong.
Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity.
J Neural Eng. 2007. 4:26-34. PMID: 17409477
W.J. Duncanson, M.A. Figa, K. Hallock, S. Zalipsky, J.A. Hamilton, and J. Y. Wong.
Targeted binding of PLA microparticles with lipid-PEG-tethered ligands.
Biomaterials. 2007. 28: 4991-4999. PMID: 17707503
S. Koester, H.M. Evans, J.Y. Wong, and T. Pfohl.
An in-situ Study of Collagen Self-Assembly Processes.
Biomacromolecules. 2007. 9: 199-207. PMID: 18078321
J.Y. Wong and T.L. Kuhl.
Dynamics of Membrane Adhesion: The role of polyethylene glycol spacers, ligand-receptor bond strength, and rupture pathway.
Langmuir. 2008. 24: 1225-1231. PMID: 18186654
G.R. Houtchens, M.D. Foster, T.A. Desai, E.F. Morgan, and J.Y. Wong.
Combined Effects of Microtopography and Cyclic Strain on Vascular Smooth Muscle Cell Orientation.
J Biomech. 2008. 41: 762-769. PMID: 18222460
B.C. Isenberg, Y. Tsuda, C. Williams, T. Shimizu, M. Yamato, T. Okano, and J.Y. Wong.
A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization.
Biomaterials. 2008. 29(17): 2565-72. PMID: 18377979
Zannis
Kypreos, K.E., V.I. Zannis.
Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.
Biochem. J. 2007. 302:359-367. PMID: 17206937
Chroni, A., G. Koukos, A. Duka, V.I. Zannis.
The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of a-HDL but not preb-HDL particles in vivo.
Biochemistry. 2007. 46:5697-5708. PMID: 17447731
Drosatos, K., K.E. Kypreos, V.I. Zannis.
Residues Leu261, Trp264 and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of high density lipoprotein.
Biochemistry. 2007. 46:9645-9653. PMID: 17655277
Drosatos, K., D. Sanoudou, K.E. Kypreos, D. Kardassis. V.I. Zannis.
A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice.
J. Biol. Chem. 2007. 282:19556-19564. PMID: 17456467
Koukos, G., A. Chroni, A. Duka, D. Kardassis, V.I. Zannis.
LCAT can rescue the abnormal phenotype produced by the natural apoA-I mutations Leu141Arg(Pisa and (Leu159ARg)Fin.
Biochemistry. 2007. 46:10713-10721. PMID: 17711302
Koukos, G., A. Chroni, A. Duka, D. Kardassis, V.I. Zannis.
Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: Correction of the abnormal HDL phenotypes by treatment with LCAT. Biochem. J. 2007. 406:167-174. PMID: 17506726
Nieland, T.J.F., S. Shaw, F.A. Jaipuri, J.L. Duffner, A.N. Koehler, S. Banakos, V.I. Zannis, T. Kirchhausen, M. Krieger.
Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008. 47:460-472. PMID: 18067275
Earlier Publications (2006 and previous)
Dr. Christopher Akey’s Representative Publications:
Yu X, Wang L, Acehan D, Wang X, Akey CW.
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer.
J Mol Biol. 2006 Jan 20;355(3):577-89. Epub 2005 Nov 8.
PMID: 16310803 [PubMed - indexed for MEDLINE]
Yu X, Acehan D, Menetret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW.
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform.
Structure. 2005 Nov;13(11):1725-35.
PMID: 16271896 [PubMed - in process]
Menetret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW.
Architecture of the ribosome-channel complex derived from native membranes.
J Mol Biol. 2005 Apr 29;348(2):445-57.
PMID: 15811380 [PubMed - indexed for MEDLINE]
Namboodiri VM, Schmidt-Zachmann MS, Head JF, Akey CW.
Purification, crystallization and preliminary X-ray analysis of the N-terminal domain of NO38, a nucleolar protein from Xenopus laevis.
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2325-7. Epub 2004 Nov 26.
PMID: 15583381 [PubMed - indexed for MEDLINE]
Namboodiri VM, Akey IV, Schmidt-Zachmann MS, Head JF, Akey CW.
The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus.
Structure. 2004 Dec;12(12):2149-60.
PMID: 15576029 [PubMed - indexed for MEDLINE]
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Dr. David Atkinson’s Representative Publications:
Nolte RT, Atkinson D.
Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism.
Biophys J. 1992 Nov;63(5):1221-39.
PMID: 1477274 [PubMed - indexed for MEDLINE]
Spin JM, Atkinson D.
Cryoelectron microscopy of low density lipoprotein in vitreous ice.
Biophys J. 1995 May;68(5):2115-23.
Fang Y, Gursky O, Atkinson D.
Lipid-binding studies of human apolipoprotein A-I and its terminally truncated mutants.
Biochemistry. 2003 Nov 18;42(45):13260-8.
PMID: 14609337 [PubMed - indexed for MEDLINE]
Gorshkova IN, Liadaki K, Gursky O, Atkinson D, Zannis VI.
Probing the lipid-free structure and stability of apolipoprotein A-I by mutation.
Biochemistry. 2000 Dec 26;39(51):15910-9.
PMID: 11123918 [PubMed - indexed for MEDLINE]
Gursky O, Atkinson D.
High- and low-temperature unfolding of human high-density apolipoprotein A-2.
Protein Sci. 1996 Sep;5(9):1874-82.
PMID: 8880911 [PubMed - indexed for MEDLINE]
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Dr. Victoria M. Bolotina’s Representative Publications:
Csutora P, Zarayskiy V, Peter K, Monje F, Smani T, Zakharov SI, Litvinov D, Bolotina VM.
Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway.
J Biol Chem. 2006 Nov 17;281(46):34926-35. Epub 2006 Sep 26.
Bolotina VM, Csutora P.
CIF and other mysteries of the store-operated Ca2+-entry pathway.
Trends Biochem Sci. 2005 Jul;30(7):378-87. Review.
PMID: 15951181 [PubMed - indexed for MEDLINE]
Zakharov SI, Smani T, Dobrydneva Y, Monje F, Fichandler C, Blackmore PF, Bolotina VM.
Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca(2+) influx.
Mol Pharmacol. 2004 Sep;66(3):702-7.
PMID: 15322263 [PubMed - indexed for MEDLINE]
Gwanyanya A, Amuzescu B, Zakharov SI, Macianskiene R, Sipido KR, Bolotina VM, Vereecke J, Mubagwa K.
Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation.
J Physiol. 2004 Sep 15;559(Pt 3):761-76. Epub 2004 Jul 22.
PMID: 15272039 [PubMed - indexed for MEDLINE]
Smani T, Zakharov SI, Leno E, Csutora P, Trepakova ES, Bolotina VM.
Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry.
J Biol Chem. 2003 Apr 4;278(14):11909-15. Epub 2003 Jan 23.
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Dr. Richard Cohen’s Representative Publications:
Kuster GM, Pimentel DR, Adachi T, Ido Y, Brenner DA, Cohen RA, Liao R, Siwik DA, Colucci WS.
Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras.
Circulation. 2005 Mar 8;111(9):1192-8. Epub 2005 Feb 21.
PMID: 15723974 [PubMed - indexed for MEDLINE]
Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA.
Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II.
Circulation. 2005 Jul 12;112(2):257-63. Epub 2005 Jul 5.
PMID: 15998684 [PubMed - indexed for MEDLINE]
Zuccollo A, Shi C, Mastroianni R, Maitland-Toolan KA, Weisbrod RM, Zang M, Xu S, Jiang B, Oliver-Krasinski JM, Cayatte AJ, Corda S, Lavielle G, Verbeuren TJ, Cohen RA.
The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus.
Circulation. 2005 Nov 8;112(19):3001-8. Epub 2005 Oct 31.
PMID: 16260636 [PubMed - indexed for MEDLINE]
Xu S, Jiang B, Maitland KA, Bayat H, Gu J, Nadler JL, Corda S, Lavielle G, Verbeuren TJ, Zuccollo A, Cohen RA.
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.
Diabetes. 2006 Jan;55(1):110-9.
PMID: 16380483 [PubMed - indexed for MEDLINE]
Clavreul N, Adachi T, Pimental DR, Ido Y, Schoneich C, Cohen RA.
S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells.
FASEB J. 2006 Mar;20(3):518-20. Epub 2006 Jan 13.
PMID: 16415107 [PubMed - indexed for MEDLINE]
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Dr. Wilson S. Colucci’s Representative Publications:
Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R.
CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation.
Circ Res. 2005 Jul 8;97(1):52-61. Epub 2005 Jun 9.
PMID: 15947249 [PubMed - indexed for MEDLINE]
Rude MK, Duhaney TA, Kuster GM, Judge S, Heo J, Colucci WS, Siwik DA, Sam F.
Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes.
Hypertension. 2005 Sep;46(3):555-61. Epub 2005 Jul 25.
PMID: 16043662 [PubMed - indexed for MEDLINE]
Izumiya Y, Shiojima I, Sato K, Sawyer DB, Colucci WS, Walsh K.
Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload.
Hypertension. 2006 May;47(5):887-93. Epub 2006 Mar 27.
PMID: 16567591 [PubMed - indexed for MEDLINE]
Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K.
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure.
J Clin Invest. 2005 Aug;115(8):2108-18.
PMID: 16075055 [PubMed - indexed for MEDLINE]
Pimentel DR, Adachi T, Ido Y, Heibeck T, Jiang B, Lee Y, Melendez JA, Cohen RA, Colucci WS.
Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation.
J Mol Cell Cardiol. 2006 Oct;41(4):613-22. Epub 2006 Jun 27.
PMID: 16806262 [PubMed - indexed for MEDLINE]
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Dr. Barbara Corkey’s Representative Publications:
Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE.
Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.
Biochem J. 2007 Apr 1;403(1):197-205.
PMID: 17181533 [PubMed - indexed for MEDLINE]
Getty-Kaushik L, Song DH, Boylan MO, Corkey BE, Wolfe MM.
Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification.
Obesity (Silver Spring). 2006 Jul;14(7):1124-31.
PMID: 16899793 [PubMed - indexed for MEDLINE]
Getty-Kaushik L, Richard AM, Corkey BE.
Glucose-dependent insulin modulation of oscillatory lipolysis in perifused rat adipocytes.
Obes Res. 2005 Dec;13(12):2058-65.
PMID: 16421338 [PubMed - indexed for MEDLINE]
Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL.
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. Epub 2006 Dec 5.
PMID: 17148751 [PubMed - indexed for MEDLINE]
Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE.
Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.
Biochem J. 2007 Apr 1;403(1):197-205.
PMID: 17181533 [PubMed - indexed for MEDLINE]
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Dr. Catherine Costello’s Representative Publications:
Monis GF, Schultz C, Ren R, Eberhard J, Costello C, Connors L, Skinner M, Trinkaus-Randall V.
Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts.
Am J Pathol. 2006 Dec;169(6):1939-52.
PMID: 17148659 [PubMed - indexed for MEDLINE]
McComb ME, Perlman DH, Huang H, Costello CE.
Evaluation of an on-target sample preparation system for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in conjunction with normal-flow peptide high-performance liquid chromatography for peptide mass fingerprint analyses.
Rapid Commun Mass Spectrom. 2007;21(1):44-58.
PMID: 17133622 [PubMed - indexed for MEDLINE]
Kingsbury JS, Theberge R, Karbassi JA, Lim A, Costello CE, Connors LH.
Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry.
Anal Chem. 2007 Mar 1;79(5):1990-8. Epub 2007 Jan 30.
PMID: 17261023 [PubMed - indexed for MEDLINE]
Sethuraman M, Clavreul N, Huang H, McComb ME, Costello CE, Cohen RA.
Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry.
Free Radic Biol Med. 2007 Mar 15;42(6):823-9. Epub 2006 Dec 16. PMID: 17320764 [PubMed - indexed for MEDLINE]
Perlman DH, Huang H, Dauly C, Costello CE, McComb ME.
Coupling of protein HPLC to MALDI-TOF MS using an on-target device for fraction collection, concentration, digestion, desalting, and matrix/analyte cocrystallization.
Anal Chem. 2007 Mar 1;79(5):2058-66. Epub 2007 Jan 26.
PMID: 17256876 [PubMed - indexed for MEDLINE]
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Dr. Harrison Farber’s Representative Publications:
Fisher KA, Serlin DM, Wilson KC, Walter RE, Berman JS, Farber HW.
Sarcoidosis-associated pulmonary hypertension: outcome with long-term epoprostenol treatment.
Chest. 2006 Nov;130(5):1481-8.
PMID: 17099027 [PubMed - indexed for MEDLINE]
Steiner MK, Preston IR, Klinger JR, Criner GJ, Waxman AB, Farber HW, Hill NS.
Conversion to bosentan from prostacyclin infusion therapy in pulmonary arterial hypertension: a pilot study.
Chest. 2006 Nov;130(5):1471-80.
PMID: 17099026 [PubMed - indexed for MEDLINE]
Fiack CA, Farber HW.
Heart failure with preserved ejection fraction.
N Engl J Med. 2006 Oct 26;355(17):1828; author reply 1830-1. No abstract available.
PMID: 17065647 [PubMed - indexed for MEDLINE]
Patterson KC, Weissmann A, Ahmadi T, Farber HW.
Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension.
Ann Intern Med. 2006 Jul 18;145(2):152-3. No abstract available.
PMID: 16847299 [PubMed - indexed for MEDLINE].
Tam DH, Farber HW.
Pulmonary hypertension and beta-thalassemia major: report of a case, its treatment, and a review of the literature.
Am J Hematol. 2006 Jun;81(6):443-7.
PMID: 16680745 [PubMed - indexed for MEDLINE]
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Dr. Lindsay Farrer’s Representative Publications:
Erlich PM, Lunetta KL, Cupples LA, Huyck M, Green RC, Baldwin CT, Farrer LA; MIRAGE Study Group.
Polymorphisms in the PON gene cluster are associated with Alzheimer disease.
Hum Mol Genet. 2006 Jan 1;15(1):77-85. Epub 2005 Nov 30.
PMID: 16319130 [PubMed - indexed for MEDLINE]
Yu Y, Panhuysen C, Kranzler HR, Hesselbrock V, Rounsaville B, Weiss R, Brady K, Farrer LA, Gelernter J.
Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.
Hum Mol Genet. 2006 Jul 15;15(14):2192-9. Epub 2006 Jun 1.
PMID: 16740595 [PubMed - indexed for MEDLINE]
Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL, Wilcox MA, Farrer LA, Barzilai N, Baldwin CT, Asea A.
Serum heat shock protein 70 level as a biomarker of exceptional longevity.
Mech Ageing Dev. 2006 Nov;127(11):862-8. Epub 2006 Oct 6.
PMID: 17027907 [PubMed - indexed for MEDLINE]
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Nat Genet. 2007 Feb;39(2):168-77. Epub 2007 Jan 14.
PMID: 17220890 [PubMed - indexed for MEDLINE]
Nolan VG, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C, Mahabir RN, Homan EP, Wyszynski DF, Fabry ME, Nagel RL, Farrer LA, Steinberg MH.
Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.
Am J Hematol. 2007 Mar;82(3):179-84.
PMID: 17034027 [PubMed - indexed for MEDLINE]
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Dr. Carl Franzblau’s Representative Publications:
Hsiao H, Stone PJ, Toselli P, Rosenbloom J, Franzblau C, Schreiber BM.
The role of the carboxy terminus of tropoelastin in its assembly into the elastic fiber.
Connect Tissue Res. 1999;40(2):83-95.
PMID: 10761633 [PubMed - indexed for MEDLINE]
Stone PJ, Lucey EC, Snider GL, Franzblau C.
Distribution of elastin in hamsters and the turnover rates of different elastin pools.
Proc Soc Exp Biol Med. 1997 May;215(1):94-101.
PMID: 9142143 [PubMed - indexed for MEDLINE]
Stone PJ, Morris TA 3rd, Franzblau C, Snider GL.
Preliminary evidence that augmentation therapy diminishes degradation of cross-linked elastin in alpha-1-antitrypsin-deficient humans.
Respiration. 1995;62(2):76-9.
PMID: 7784713 [PubMed - indexed for MEDLINE]
Stone PJ, Konstan MW, Berger M, Dorkin HL, Franzblau C, Snider GL.
Elastin and collagen degradation products in urine of patients with cystic fibrosis.
Am J Respir Crit Care Med. 1995 Jul;152(1):157-62.
PMID: 7599816 [PubMed - indexed for MEDLINE]
Stone PJ, Bryan-Rhadfi J, Shaw HA, Franzblau C.
Isolation of hydroxylysyl pyridinoline, a mature collagen crosslink from neonatal rat aorta smooth muscle cell cultures.
Matrix. 1992 Nov;12(5):381-7.
PMID: 1484505 [PubMed - indexed for MEDLINE]
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Dr. Jane Freedman’s Representative Publications:
Albers AR, Varghese S, Vitseva O, Vita JA, Freedman JE.
The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease.
Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):e179-80. No abstract available.
PMID: 15528483 [PubMed - indexed for MEDLINE]
Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE.
Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates.
J Cardiovasc Pharmacol. 2005 Oct;46(4):445-51.
PMID: 16160595 [PubMed - indexed for MEDLINE]
Iafrati MD, Vitseva O, Tanriverdi K, Blair P, Rex S, Chakrabarti S, Varghese S, Freedman JE.
Compensatory mechanisms influence hemostasis in setting of eNOS deficiency.
Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1627-32. Epub 2004 Nov 24.
PMID: 15563534 [PubMed - indexed for MEDLINE]
Freedman JE.
Molecular regulation of platelet-dependent thrombosis.
Circulation. 2005 Oct 25;112(17):2725-34.
PMID: 16246969 [PubMed - indexed for MEDLINE]
Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE.
CD40 ligand influences platelet release of reactive oxygen intermediates.
Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2428-34. Epub 2005 Sep 1.
PMID: 16141403 [PubMed - indexed for MEDLINE]
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Dr. Haralambos Gavras’ Representative Publications:
Sun B, Kintsurashvili E, Ona D, Ignjacev-Lazich I, Gavras I, Gavras H.
Inhibition of the alpha(1D)-adrenergic receptor gene by RNA interference (RNAi) in rat vascular smooth muscle cells and its effects on other adrenergic receptors.
Vascul Pharmacol. 2007 May;46(5):367-72. Epub 2007 Jan 23.
PMID: 17307398 [PubMed - indexed for MEDLINE]
Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K.
The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
J Clin Invest. 2006 Jul;116(7):1913-23.
PMID: 16823489 [PubMed - indexed for MEDLINE]
Duka A, Duka I, Gao G, Shenouda S, Gavras I, Gavras H.
Role of bradykinin B1 and B2 receptors in normal blood pressure regulation.
Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E268-74. Epub 2006 Feb 28.
PMID: 16507603 [PubMed - indexed for MEDLINE]
Duka A, Schwartz F, Duka I, Johns C, Melista E, Gavras I, Gavras H.
A novel gene (Cmya3) induced in the heart by angiotensin II-dependent but not salt-dependent hypertension in mice.
Am J Hypertens. 2006 Mar;19(3):275-81.
PMID: 16500513 [PubMed - indexed for MEDLINE]
Shenouda SM, Johns C, Kintsurashvili E, Gavras I, Gavras H.
Long-term inhibition of the central alpha(2B)-adrenergic receptor gene via recombinant AAV-delivered antisense in hypertensive rats.
Am J Hypertens. 2006 Nov;19(11):1135-43. Erratum in: Am J Hypertens. 2007 Apr;20(4):466. Kintsurashvili, Ekaterina [added].
PMID: 17070424 [PubMed - indexed for MEDLINE]
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Dr. Noyan Gokce’s Representative Publications:
McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA.
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.
J Clin Hypertens (Greenwich). 2007 Apr;9(4):249-55.
PMID: 17396066 [PubMed - in process]
Vita JA, Brennan ML, Gokce N, Mann SA, Goormastic M, Shishehbor MH, Penn MS, Keaney JF Jr, Hazen SL.
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.
Circulation. 2004 Aug 31;110(9):1134-9. Epub 2004 Aug 23.
PMID: 15326065 [PubMed - indexed for MEDLINE]
Gokce N, Vita JA, McDonnell M, Forse AR, Istfan N, Stoeckl M, Lipinska I, Keaney JF Jr, Apovian CM.
Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients.
Am J Cardiol. 2005 Jan 15;95(2):266-8.
PMID: 15642566 [PubMed - indexed for MEDLINE]
Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, Keaney JF Jr, Frei B, Vita JA.
Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease.
Free Radic Biol Med. 2005 Feb 15;38(4):499-506.
PMID: 15649652 [PubMed - indexed for MEDLINE]
Widlansky ME, Gokce N, Keaney JF Jr, Vita JA.
The clinical implications of endothelial dysfunction.
J Am Coll Cardiol. 2003 Oct 1;42(7):1149-60. Review.
PMID: 14522472 [PubMed - indexed for MEDLINE]
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Dr. James Hamilton’s Representative Publications:
Simard JR, Zunszain PA, Ha CE, Yang JS, Bhagavan NV, Petitpas I, Curry S, Hamilton JA.
Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy.
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17958-63. Epub 2005 Dec 5.
PMID: 16330771 [PubMed - indexed for MEDLINE]
Ruberg FL, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA.
Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS.
J Lipid Res. 2006 Feb;47(2):310-7. Epub 2005 Nov 29.
PMID: 16317172 [PubMed - indexed for MEDLINE]
Guo W, Huang N, Cai J, Xie W, Hamilton JA.
Fatty acid transport and metabolism in HepG2 cells.
Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G528-34. Epub 2005 Oct 27.
PMID: 16254047 [PubMed - indexed for MEDLINE]
Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF.
Role of caveolin-1 and cholesterol in transmembrane fatty acid movement.
Biochemistry. 2006 Mar 7;45(9):2882-93.
PMID: 16503643 [PubMed - indexed for MEDLINE]
Hamilton JA, Deckelbaum RJ.
Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?
Nat Struct Mol Biol. 2007 Feb;14(2):95-7. No abstract available.
PMID: 17277799 [PubMed - indexed for MEDLINE]
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Dr. Herbert Kagan’s Representative Publications:
Lucero HA, Kagan HM.
Lysyl oxidase: an oxidative enzyme and effector of cell function.
Cell Mol Life Sci. 2006 Oct;63(19-20):2304-16. Review.
PMID: 16909208 [PubMed - indexed for MEDLINE]
Gilad GM, Kagan HM, Gilad VH.
Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer’s disease brain.
Neurosci Lett. 2005 Mar 16;376(3):210-4. Epub 2004 Dec 15.
PMID: 15721223 [PubMed - indexed for MEDLINE]
Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K.
A(3) adenosine receptor deficiency does not influence atherogenesis.
J Cell Biochem. 2004 Aug 1;92(5):1034-43.
PMID: 15258925 [PubMed - indexed for MEDLINE]
Kagan HM, Li W.
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.
J Cell Biochem. 2003 Mar 1;88(4):660-72. Review.
PMID: 12577300 [PubMed - indexed for MEDLINE]
Li W, Nugent MA, Zhao Y, Chau AN, Li SJ, Chou IN, Liu G, Kagan HM.
Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential.
J Cell Biochem. 2003 Jan 1;88(1):152-64.
PMID: 12461785 [PubMed - indexed for MEDLINE]
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Dr. Kastya Kandror’s Representative Publications:
Shi J, Kandror KV.
The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles.
J Biol Chem. 2007 Mar 23;282(12):9008-16. Epub 2007 Jan 12.
PMID: 17220298 [PubMed - indexed for MEDLINE]
Xu Z, Huang G, Kandror KV.
Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles.
Mol Endocrinol. 2006 Nov;20(11):2890-7. Epub 2006 Jun 13.
PMID: 16772528 [PubMed - indexed for MEDLINE]
Tzatsos A, Kandror KV.
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
Mol Cell Biol. 2006 Jan;26(1):63-76.
PMID: 16354680 [PubMed - indexed for MEDLINE]
Shi J, Kandror KV.
Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes.
Dev Cell. 2005 Jul;9(1):99-108.
PMID: 15992544 [PubMed - indexed for MEDLINE]
Li LV, Kandror KV.
Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes.
Mol Endocrinol. 2005 Aug;19(8):2145-53. Epub 2005 Mar 17.
PMID: 15774496 [PubMed - indexed for MEDLINE]
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Dr. John Keaney’s Representative Publications:
McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA.
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.
J Clin Hypertens (Greenwich). 2007 Apr;9(4):249-55.
PMID: 17396066 [PubMed - in process]
Thomas SR, Schulz E, Keaney JF Jr.
Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity — role for iron-dependent oxidative stress.
Free Radic Biol Med. 2006 Aug 15;41(4):681-8. Epub 2006 May 19.
PMID: 16864001 [PubMed - indexed for MEDLINE]
Fox CS, Guo CY, Larson MG, Vasan RS, Parise H, O’Donnell CJ, D’Agostino RB Sr, Keaney JF Jr, Benjamin EJ.
Relations of inflammation and novel risk factors to valvular calcification.
Am J Cardiol. 2006 May 15;97(10):1502-5. Epub 2006 Mar 29.
PMID: 16679093 [PubMed - indexed for MEDLINE]
Kotlyar E, Vita JA, Winter MR, Awtry EH, Siwik DA, Keaney JF Jr, Sawyer DB, Cupples LA, Colucci WS, Sam F.
The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.
J Card Fail. 2006 Mar;12(2):122-7.
PMID: 16520260 [PubMed - indexed for MEDLINE]
Shapira OM, Eskenazi BR, Anter E, Joseph L, Christensen TG, Hunter CT, Lazar HL, Vita JA, Shemin RJ, Keaney JF Jr.
Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit.
J Thorac Cardiovasc Surg. 2006 Feb;131(2):388-94. Epub 2006 Jan 4.
PMID: 16434269 [PubMed - indexed for MEDLINE]
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Dr. William Lehman’s Representative Publications:
Poole KJ, Lorenz M, Evans G, Rosenbaum G, Pirani A, Craig R, Tobacman LS, Lehman W, Holmes KC.
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle.
J Struct Biol. 2006 Aug;155(2):273-84. Epub 2006 May 7.
PMID: 16793285 [PubMed - indexed for MEDLINE]
Pant K, Chereau D, Hatch V, Dominguez R, Lehman W.
Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction.
J Mol Biol. 2006 Jun 16;359(4):840-7. Epub 2006 May 4.
PMID: 16697006 [PubMed - indexed for MEDLINE]
Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W.
An atomic model of the thin filament in the relaxed and Ca2+-activated states.
J Mol Biol. 2006 Mar 31;357(3):707-17. Epub 2006 Jan 13.
PMID: 16469331 [PubMed - indexed for MEDLINE]
Cammarato A, Craig R, Sparrow JC, Lehman W.
E93K charge reversal on actin perturbs steric regulation of thin filaments.
J Mol Biol. 2005 Apr 15;347(5):889-94.
PMID: 15784249 [PubMed - indexed for MEDLINE]
Pirani A, Xu C, Hatch V, Craig R, Tobacman LS, Lehman W.
Single particle analysis of relaxed and activated muscle thin filaments.
J Mol Biol. 2005 Feb 25;346(3):761-72. Epub 2005 Jan 11.
PMID: 15713461 [PubMed - indexed for MEDLINE]
Lehman W, Craig R, Kendrick-Jones J, Sutherland-Smith AJ.
An open or closed case for the conformation of calponin homology domains on F-actin?
J Muscle Res Cell Motil. 2004;25(4-5):351-8. Review.
PMID: 15548864 [PubMed - indexed for MEDLINE]
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Dr. Joseph Loscalzo’s Representative Publications:
Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J.
Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children.
Stroke. 2007 Jan;38(1):41-9. Epub 2006 Nov 22.
PMID: 17122425 [PubMed - indexed for MEDLINE]
Handy DE, Loscalzo J.
Nitric oxide and posttranslational modification of the vascular proteome: S-nitrosation of reactive thiols.
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1207-14. Epub 2006 Mar 16. Review.
PMID: 16543494 [PubMed - indexed for MEDLINE]
Matsui R, Xu S, Maitland KA, Mastroianni R, Leopold JA, Handy DE, Loscalzo J, Cohen RA.
Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice.
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):910-6. Epub 2006 Jan 26.
PMID: 16439706 [PubMed - indexed for MEDLINE]
Handy DE, Loscalzo J.
Nitric oxide and posttranslational modification of the vascular proteome: S-nitrosation of reactive thiols.
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1207-14. Epub 2006 Mar 16. Review.
PMID: 16543494 [PubMed - indexed for MEDLINE]
Galasso G, Schiekofer S, Sato K, Shibata R, Handy DE, Ouchi N, Leopold JA, Loscalzo J, Walsh K.
Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction.
Circ Res. 2006 Feb 3;98(2):254-61. Epub 2005 Dec 22.
PMID: 16373599 [PubMed - indexed for MEDLINE]
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Dr. Matthew Nugent’s Representative Publications:
Mitsi M, Hong Z, Costello CE, Nugent MA.
Heparin-mediated conformational changes in fibronectin expose vascular endothelial growth factor binding sites.
Biochemistry. 2006 Aug 29;45(34):10319-28.
PMID: 16922507 [PubMed - indexed for MEDLINE]
Spencer JL, Stone PJ, Nugent MA.
New insights into the inhibition of human neutrophil elastase by heparin.
Biochemistry. 2006 Aug 1;45(30):9104-20.
PMID: 16866356 [PubMed - indexed for MEDLINE]
Gopalakrishnan M, Forsten-Williams K, Nugent MA, Tauber UC.
Effects of receptor clustering on ligand dissociation kinetics: theory and simulations.
Biophys J. 2005 Dec;89(6):3686-700. Epub 2005 Sep 8.
PMID: 16150967 [PubMed - indexed for MEDLINE]
Chu CL, Goerges AL, Nugent MA.
Identification of common and specific growth factor binding sites in heparan sulfate proteoglycans.
Biochemistry. 2005 Sep 13;44(36):12203-13.
PMID: 16142919 [PubMed - indexed for MEDLINE]
DiCamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, Stone PJ, Nugent MA, Panchenko MP.
Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L232-43. Epub 2006 Feb 10.
PMID: 16473861 [PubMed - indexed for MEDLINE]
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Dr. Paul Pilch’s Representative Publications:
Liu L, Jedrychowski MP, Gygi SP, Pilch PF.
Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes.
Mol Biol Cell. 2006 Oct;17(10):4249-56. Epub 2006 Jul 26.
PMID: 16870704 [PubMed - indexed for MEDLINE]
Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF.
Role of caveolin-1 and cholesterol in transmembrane fatty acid movement.
Biochemistry. 2006 Mar 7;45(9):2882-93.
PMID: 16503643 [PubMed - indexed for MEDLINE]
Gross DN, Miyoshi H, Hosaka T, Zhang HH, Pino EC, Souza S, Obin M, Greenberg AS, Pilch PF.
Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin.
Mol Endocrinol. 2006 Feb;20(2):459-66. Epub 2005 Oct 20.
PMID: 16239256 [PubMed - indexed for MEDLINE]
Hosaka T, Brooks CC, Presman E, Kim SK, Zhang Z, Breen M, Gross DN, Sztul E, Pilch PF.
p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation.
Mol Biol Cell. 2005 Jun;16(6):2882-90. Epub 2005 Mar 30.
PMID: 15800058 [PubMed - indexed for MEDLINE]
Pilch PF, Bergenhem N.
Pharmacological targeting of adipocytes/fat metabolism for treatment of obesity and diabetes.
Mol Pharmacol. 2006 Sep;70(3):779-85. Epub 2006 Jun 7. Review.
PMID: 16760360 [PubMed - indexed for MEDLINE]
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Dr. Katya Ravid’s Representative Publications:
Yang D, McCrann DJ, Nguyen H, St Hilaire C, DePinho RA, Jones MR, Ravid K.
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell. 2007 Apr;6(2):257-60. Epub 2007 Feb 7. PMID: 17291294 [PubMed - indexed for MEDLINE]
Hazony Y, Lu J, St Hilaire C, Ravid K.
Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Res. 2006;34(16):4416-28. Epub 2006 Aug 26. PMID: 16936310 [PubMed - indexed for MEDLINE]
Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K.
The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul;116(7):1913-23. PMID: 16823489 [PubMed - indexed for MEDLINE]
Nguyen HG, Chinnappan D, Urano T, Ravid K.
Nguyen HG, Yu G, Makitalo M, Yang D, Xie HX, Jones MR, Ravid K.
Conditional overexpression of transgenes in megakaryocytes and platelets in vivo. Blood. 2005 Sep 1;106(5):1559-64. Epub 2005 May 12. PMID: 15890684 [PubMed - indexed for MEDLINE]
Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St Hilaire C, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K.
Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res. 2005 May 1;305(2):277-91. PMID: 15817153 [PubMed - indexed for MEDLINE]
Yaar R, Jones MR, Chen JF, Ravid K.
Animal models for the study of adenosine receptor function. J Cell Physiol. 2005 Jan;202(1):9-20. Review. PMID: 15389588 [PubMed - indexed for MEDLINE]
Dr. Neil Ruderman’s R epresentative Publications:
LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E.
Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues.
Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E175-81. Epub 2006 Feb 7.
PMID: 16464908 [PubMed - indexed for MEDLINE]
Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN.
Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.
Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1296-303. Epub 2006 Jan 24.
PMID: 16434556 [PubMed - indexed for MEDLINE]
Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.
Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.
Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.
PMID: 16234268 [PubMed - indexed for MEDLINE]
Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB.
AMPK regulation of the growth of cultured human keratinocytes.
Biochem Biophys Res Commun. 2006 Oct 20;349(2):519-24. Epub 2006 Aug 28.
PMID: 16949049 [PubMed - indexed for MEDLINE]
Ruderman NB, Saha AK.
Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.
Obesity (Silver Spring). 2006 Feb;14 Suppl 1:25S-33S. Review.
PMID: 16642960 [PubMed - indexed for MEDLINE]
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Dr. Flora Sam’s Representative Publications:
Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, Sam F, Ouchi N, Walsh K.
Adiponectin protects against the development of systolic dysfunction following myocardial infarction.
J Mol Cell Cardiol. 2007 Jun;42(6):1065-74. Epub 2007 Mar 20.
PMID: 17499764 [PubMed - in process]
Duhaney TA, Cui L, Rude MK, Lebrasseur NK, Ngoy S, De Silva DS, Siwik DA, Liao R, Sam F.
Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload.
Hypertension. 2007 May;49(5):1084-94. Epub 2007 Mar 12.
PMID: 17353509 [PubMed - indexed for MEDLINE]
Kotlyar E, Vita JA, Winter MR, Awtry EH, Siwik DA, Keaney JF Jr, Sawyer DB, Cupples LA, Colucci WS, Sam F.
The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.
J Card Fail. 2006 Mar;12(2):122-7.
PMID: 16520260 [PubMed - indexed for MEDLINE]
Kuster GM, Kotlyar E, Rude MK, Siwik DA, Liao R, Colucci WS, Sam F.
Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload.
Circulation. 2005 Feb 1;111(4):420-7.
PMID: 15687129 [PubMed - indexed for MEDLINE]
Sam F, Xie Z, Ooi H, Kerstetter DL, Colucci WS, Singh M, Singh K.
Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion.
Am J Hypertens. 2004 Feb;17(2):188-93.
PMID: 14751663 [PubMed - indexed for MEDLINE]
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Dr. Barbara Schreiber’s Representative Publications:
Xu Y, McDonald J, Perloff E, Buttice G, Schreiber BM, Smith BD.
Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice.
Mol Immunol. 2007 Mar;44(7):1709-21. Epub 2006 Sep 18.
PMID: 16982097 [PubMed - indexed for MEDLINE]
Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K.
The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
J Clin Invest. 2006 Jul;116(7):1913-23.
PMID: 16823489 [PubMed - indexed for MEDLINE]
Johnson RJ, Williams JM, Schreiber BM, Elfe CD, Lennon-Hopkins KL, Skrzypek MS, White RD.
Analysis of gene ontology features in microarray data using the Proteome BioKnowledge Library.
In Silico Biol. 2005;5(4):389-99.
PMID: 16268783 [PubMed - indexed for MEDLINE]
Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St Hilaire C, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K.
Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle.
Exp Cell Res. 2005 May 1;305(2):277-91.
PMID: 15817153 [PubMed - indexed for MEDLINE]
Schadinger SE, Bucher NL, Schreiber BM, Farmer SR.
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.
Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1195-205. Epub 2005 Jan 11.
PMID: 15644454 [PubMed - indexed for MEDLINE]
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Dr. Donald Small’s Representative Publications:
Wang L, Walsh MT, Small DM.
Apolipoprotein B is conformationally flexible but anchored at a triolein/water interface: a possible model for lipoprotein surfaces.
Proc Natl Acad Sci U S A. 2006 May 2;103(18):6871-6. Epub 2006 Apr 24.
PMID: 16636271 [PubMed - indexed for MEDLINE]
Wang L, Atkinson D, Small DM.
The interfacial properties of ApoA-I and an amphipathic alpha-helix consensus peptide of exchangeable apolipoproteins at the triolein/water interface.
J Biol Chem. 2005 Feb 11;280(6):4154-65.
PMID: 15695525 [PubMed - indexed for MEDLINE]
Wang L, Small DM.
Interfacial properties of amphipathic beta strand consensus peptides of apolipoprotein B at oil/water interfaces.
J Lipid Res. 2004 Sep;45(9):1704-15. Epub 2004 Jul 1.
PMID: 15231853 [PubMed - indexed for MEDLINE]
Small DM.
Role of ABC transporters in secretion of cholesterol from liver into bile.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):4-6. Epub 2002 Dec 30. No abstract available.
PMID: 12509503 [PubMed - indexed for MEDLINE]
Herscovitz H, Derksen A, Walsh MT, McKnight CJ, Gantz DL, Hadzopoulou-Cladaras M, Zannis V, Curry C, Small DM.
The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins.
J Lipid Res. 2001 Jan;42(1):51-9.
PMID: 11160365 [PubMed - indexed for MEDLINE]
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Dr. Barbara Smith’s Representative Publications:
Xu Y, McDonald J, Perloff E, Buttice G, Schreiber BM, Smith BD.
Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice.
Mol Immunol. 2007 Mar;44(7):1709-21. Epub 2006 Sep 18.
PMID: 16982097 [PubMed - indexed for MEDLINE]
Buttice G, Miller J, Wang L, Smith BD.
Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells.
Circ Res. 2006 Mar 3;98(4):472-9. Epub 2006 Jan 26.
PMID: 16439692 [PubMed - indexed for MEDLINE]
Xu Y, Sengupta PK, Seto E, Smith BD.
Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression.
J Biol Chem. 2006 Apr 7;281(14):9260-70. Epub 2006 Feb 6.
PMID: 16464847 [PubMed - indexed for MEDLINE]
Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD.
Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma).
J Biol Chem. 2004 Oct 1;279(40):41319-32. Epub 2004 Jul 6.
PMID: 15247294 [PubMed - indexed for MEDLINE]
Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD.
Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex.
J Biol Chem. 2003 Dec 5;278(49):49134-44. Epub 2003 Sep 10.
PMID: 12968017 [PubMed - indexed for MEDLINE]
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Dr. Joseph Vita’s Representative Publications:
Mitchell GF, Guo CY, Kathiresan S, Vasan RS, Larson MG, Vita JA, Keyes MJ, Vyas M, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O’Donnell CJ, Hirschhorn JN, Benjamin EJ.
Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.
Hypertension. 2007 Jun;49(6):1285-90. Epub 2007 Apr 2.
PMID: 17404185 [PubMed - indexed for MEDLINE]
Mitchell GF, Guo CY, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D.
Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study.
Circulation. 2007 May 22;115(20):2628-36. Epub 2007 May 7.
PMID: 17485578 [PubMed - indexed for MEDLINE]
McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA.
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.
J Clin Hypertens (Greenwich). 2007 Apr;9(4):249-55.
PMID: 17396066 [PubMed - in process]
Silver AE, Vita JA.
Shear-stress-mediated arterial remodeling in atherosclerosis: too much of a good thing?
Circulation. 2006 Jun 20;113(24):2787-9. No abstract available.
PMID: 16785350 [PubMed - indexed for MEDLINE]
Shapira OM, Eskenazi BR, Anter E, Joseph L, Christensen TG, Hunter CT, Lazar HL, Vita JA, Shemin RJ, Keaney JF Jr.
Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit.
J Thorac Cardiovasc Surg. 2006 Feb;131(2):388-94. Epub 2006 Jan 4.
PMID: 16434269 [PubMed - indexed for MEDLINE]
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Dr. Kenneth Walsh’s Representative Publications:
Ouchi N, Walsh K.
Adiponectin as an anti-inflammatory factor.
Clin Chim Acta. 2007 May 1;380(1-2):24-30. Epub 2007 Feb 2.
PMID: 17343838 [PubMed - in process]
Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, Walsh K.
Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.
J Clin Invest. 2007 Feb;117(2):375-86. Epub 2007 Jan 25.
PMID: 17256056 [PubMed - indexed for MEDLINE]
Lee HY, Chung JW, Youn SW, Kim JY, Park KW, Koo BK, Oh BH, Park YB, Chaqour B, Walsh K, Kim HS.
Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia.
Circ Res. 2007 Feb 16;100(3):372-80. Epub 2007 Jan 18.
PMID: 17234971 [PubMed - indexed for MEDLINE]
Hopkins TA, Ouchi N, Shibata R, Walsh K.
Adiponectin actions in the cardiovascular system.
Cardiovasc Res. 2007 Apr 1;74(1):11-8. Epub 2006 Oct 20. Review.
PMID: 17140553 [PubMed - indexed for MEDLINE]
Fisslthaler B, Fleming I, Keseru B, Walsh K, Busse R.
Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1.
Circ Res. 2007 Feb 2;100(2):e12-21. Epub 2007 Jan 11.
PMID: 17218607 [PubMed - indexed for MEDLINE]
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Dr. Vassillis Zannis’ Representative Publications:
Koukos G, Chroni A, Duka A, Kardassis D, Zannis VI.
Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: The abnormal HDL phenotypes can be corrected by treatment with LCAT.
Biochem J. 2007 May 16; [Epub ahead of print]
PMID: 17506726 [PubMed - as supplied by publisher]
Singaraja RR, Visscher H, James ER, Chroni A, Coutinho JM, Brunham LR, Kang MH, Zannis VI, Chimini G, Hayden MR.
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
Circ Res. 2006 Aug 18;99(4):389-97. Epub 2006 Jul 27.
PMID: 16873719 [PubMed - indexed for MEDLINE]
Gorshkova IN, Liu T, Kan HY, Chroni A, Zannis VI, Atkinson D.
Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation.
Biochemistry. 2006 Jan 31;45(4):1242-54.
PMID: 16430220 [PubMed - indexed for MEDLINE]
Chroni A, Duka A, Kan HY, Liu T, Zannis VI.
Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.
Biochemistry. 2005 Nov 1;44(43):14353-66.
PMID: 16245952 [PubMed - indexed for MEDLINE]
Chroni A, Kan HY, Kypreos KE, Gorshkova IN, Shkodrani A, Zannis VI.
Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.
Biochemistry. 2004 Aug 17;43(32):10442-57.
PMID: 15301543 [PubMed - indexed for MEDLINE]
