Zhen Y. Jiang, MD, PhD

Associate Professor, Pharmacology & Experimental Therapeutics

Zhen Jiang
617.638.4300
650 Albany St Evans Biomed Research Ctr

Biography

Experience

Dr. Jiang was trained as a Medical Doctor before earning his M.S. in Pharmacology from Peking Union Medical College, China, and a Ph.D. in Biochemistry from University College, the University of London, UK. He did his postdoctoral research training at the Joslin Diabetes Center, Harvard Medical School in Boston before working as an Instructor/Research Assistant Professor in the Program in Molecular Medicine at the University of Massachusetts Medical School. Dr. Jiang was then recruited to the Diabetes and Obesity Research Center at Sanford-Burnham Medical Research Institute as an Assistant Professor in 2008. Dr. Jiang has been a faculty member in the Department of Pharmacology and Whitaker Cardiovascular Institute at Boston University School of Medicine since 2013.

Research Interests

Jiang lab is interested in understanding how nutritional factors, obesity and gut microbiota influence myelopoiesis and innate immunity in connection with adipose inflammation, insulin sensitivity, metabolic and vascular functions. Currently, Jiang lab is mainly focused on the following research areas: (1) Understanding how innate immunity regulates metabolic and vascular functions. In particular, we are exploring the role of neutrophils and neutrophil elastase in the development of adipose inflammation, insulin resistance and vascular dysfunction (Mansuy-Aubert V et al, Cell Metabolism 2013). (2) Investigating the role of CDP138, a novel calcium-binding phosphoprotein, in the regulation of glucose and lipid metabolisms, thermogenesis, fat browning, and cardiovascular functions (Xie X et al, Cell Metabolism 2011). Approaches used in the lab include flow cytometry, live cell imaging, bone marrow transplantation, transcriptional regulation, cell differentiation, and genetically modified animal models fed with high-fat diet.

Other Positions

  • Associate Professor, Endocrinology, Diabetes & Nutrition, Medicine, Boston University School of Medicine
  • Associate Professor, Cardiovascular Medicine, Medicine, Boston University School of Medicine

Education

  • Jiangxi University of Traditional Chinese Medicine, MD
  • University of London, PhD
  • China Academy of Chinese Medical Sciences (CACMS), MSc

Publications

  • Published on 1/29/2018

    Zhou QL, Song Y, Huang CH, Huang JY, Gong Z, Liao Z, Sharma AG, Greene L, Deng JZ, Rigor MC, Xie X, Qi S, Ayala JE, Jiang ZY. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018 Jan 29. PMID: 29378832.

    Read at: PubMed
  • Published on 2/15/2017

    Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017 Mar 24; 292(12):4770-4776. PMID: 28202548.

    Read at: PubMed
  • Published on 4/2/2013

    Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):534-48. PMID: 23562077.

    Read at: PubMed
  • Published on 9/7/2011

    Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Kr├╝ger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7; 14(3):378-89. PMID: 21907143.

    Read at: PubMed
  • Published on 6/28/2010

    Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9. PMID: 20587420.

    Read at: PubMed
  • Published on 5/1/2008

    Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55. PMID: 18215134.

    Read at: PubMed
  • Published on 3/30/2005

    Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8. PMID: 15799971.

    Read at: PubMed
  • Published on 11/1/2004

    Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21. PMID: 15494023.

    Read at: PubMed
  • Published on 1/1/2004

    Zhou QL, Park JG, Jiang ZY, Holik J, Mitra P, Semitz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signaling by si RNA-b ased gene silencing. Biochemical Soc. Transactions. 2004; 32:817-21.

  • Published on 6/13/2003

    Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74. PMID: 12808134.

    Read at: PubMed

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