Weiming Xia, PhD

Research Associate Professor, Pharmacology & Experimental Therapeutics

Weiming Xia
(617) 638-4300
72 E. Concord St Instructional (L)

Biography

Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

Other Positions

  • Bedford VA - Edith Nourse Rogers Memorial VA Hosp

Education

  • University of Texas Health Science Center at Houston, PhD
  • University of Texas Health Science Center at Houston, MS
  • Fudan University, BS

Publications

  • Published on 1/1/2017

    Zhu H, Stern RA, Tao Q, Bourlas A, Essis MD, Chivukula M, Rosenzweig J, Steenkamp D, Xia W, Mercier GA, Tripodis Y, Farlow M, Kowall N, Qiu WQ. An amylin analog used as a challenge test for Alzheimer's disease. Alzheimers Dement (N Y). 2017 Jan; 3(1):33-43. PMID: 28503657.

    Read at: PubMed
  • Published on 9/29/2016

    Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. PLoS One. 2016; 11(9):e0163072. PMID: 27684569.

    Read at: PubMed
  • Published on 1/15/2016

    Lee HK, Morin P, Xia W. Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient. Stem Cell Res. 2016 Mar; 16(2):213-5. PMID: 27345971.

    Read at: PubMed
  • Published on 11/2/2015

    Xia W, Mo H. Potential of tocotrienols in the prevention and therapy of Alzheimer's disease. J Nutr Biochem. 2016 May; 31:1-9. PMID: 27133418.

    Read at: PubMed
  • Published on 7/21/2015

    Lee HK, Morin P, Wells J, Hanlon EB, Xia W. Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells. Stem Cell Res. 2015 Sep; 15(2):325-7. PMID: 26246272.

    Read at: PubMed
  • Published on 7/2/2015

    Kong R, Chang S, Xia W, Wong ST. Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1. J Struct Biol. 2015 Aug; 191(2):120-9. PMID: 26142917.

    Read at: PubMed
  • Published on 5/6/2015

    Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 Jul; 130(1):21-34. PMID: 25943889.

    Read at: PubMed
  • Published on 1/1/2015

    Findeis MA, Schroeder FC, Creaser SP, McKee TD, Xia W. Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts. Medicines. 2015; (2):127-140.

    Read at: Custom
  • Published on 4/11/2014

    Zhang Y, Shao H, Dong Y, Swain CA, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener. 2014; 3(1):8. PMID: 24725331.

    Read at: PubMed
  • Published on 3/1/2014

    Cai H, Yang Z, Cao X, Xia W, Xu X. A new iterative triclass thresholding technique in image segmentation. IEEE Trans Image Process. 2014 Mar; 23(3):1038-46. PMID: 24474373.

    Read at: PubMed

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