Dr. Kumaresan’s expertise is in behavioral neuropharmacology. Dr. Kumaresan studies the neurobiological underpinnings of addiction using cellular, molecular and behavioral methods. The overall research objective is to study neuronal activity-dependent plasticity and its relevance for brain disorders. The current focus is to understand the neurobiological bases of addiction to psychostimulants. Recidivism to drug abuse is a major hurdle in the successful treatment of addiction. Illicit drug use usurps neural circuits involved in survival enhancing behaviors. The goal is to elucidate the cellular and molecular underpinnings of drug-induced enduring neural plasticity in these circuits using a combination of behavioral, cellular and molecular approaches. In particular, Dr. Kumaresan employs a novel approach of using cell-permeable peptides that disrupt protein-protein interactions in vivo in order to study ongoing behavior. These approaches are expected to lead to successful treatment of relapse precipitated by drug re-exposure, drug-associated cues and stress. Knowledge gained from these studies will also be applicable to the treatment of other brain dysfunctions involving persistent memories such as PTSD. Research techniques used include: immunocytochemistry, western blots, operant conditioning methods and site-specific intracranial microinjections of pharmacological reagents, viral vectors encoding specific constructs designed to interfere with protein-protein interactions and cell permeable peptides.
- University of Rhode Island, PhD
- University of Rhode Island, MS
- University of Madras, BS
- GMS PM 701 A1
- GMS PM702 A1
- Published on 9/1/2010
Sadri-Vakili G, Kumaresan V, Schmidt HD, Famous KR, Chawla P, Vassoler FM, Overland RP, Xia E, Bass CE, Terwilliger EF, Pierce RC, Cha JH. Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. J Neurosci. 2010 Sep 1; 30(35):11735-44. PMID: 20810894.
- Published on 4/5/2009
Kumaresan V, Yuan M, Yee J, Famous KR, Anderson SM, Schmidt HD, Pierce RC. Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behav Brain Res. 2009 Sep 14; 202(2):238-44. PMID: 19463707.
- Published on 10/22/2008
Famous KR, Kumaresan V, Sadri-Vakili G, Schmidt HD, Mierke DF, Cha JH, Pierce RC. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. J Neurosci. 2008 Oct 22; 28(43):11061-70. PMID: 18945913.
- Published on 2/17/2008
Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JH, Pierce RC. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci. 2008 Mar; 11(3):344-53. PMID: 18278040.
- Published on 12/5/2005
Schmidt HD, Anderson SM, Famous KR, Kumaresan V, Pierce RC. Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. Eur J Pharmacol. 2005 Dec 5; 526(1-3):65-76. PMID: 16321382.
- Published on 8/11/2005
Pierce RC, Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev. 2006; 30(2):215-38. PMID: 16099045.
- Published on 1/1/1998
Kumaresan V, Kang C, Simmons AM. Development and differentiation of the anuran auditory brainstem during metamorphosis: an acetylcholinesterase histochemical study. Brain Behav Evol. 1998; 52(3):111-25. PMID: 9693158.