Thor D. Stein, MD, PhD

Assistant Professor, Pathology & Laboratory Medicine

Thor Stein
617.599.2684
150 S Huntington Avenue

Biography

Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Boston University School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

Other Positions

  • VA Boston Healthcare System

Education

  • University of Wisconsin Madison, MD
  • University of Wisconsin Madison, PhD
  • University of Wisconsin Madison, BS

Publications

  • Published on 3/7/2019

    Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimers Dement. 2019 May; 15(5):686-698. PMID: 30852157.

    Read at: PubMed
  • Published on 2/15/2019

    Signaevsky M, Prastawa M, Farrell K, Tabish N, Baldwin E, Han N, Iida MA, Koll J, Bryce C, Purohit D, Haroutunian V, McKee AC, Stein TD, White CL, Walker J, Richardson TE, Hanson R, Donovan MJ, Cordon-Cardo C, Zeineh J, Fernandez G, Crary JF. Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy. Lab Invest. 2019 Feb 15. PMID: 30770886.

    Read at: PubMed
  • Published on 1/1/2019

    Wright LM, Stein TD, Jun G, Chung J, McConnell K, Fiorello M, Siegel N, Ness S, Xia W, Turner KL, Subramanian ML. Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor. J Alzheimers Dis. 2019; 68(4):1429-1438. PMID: 30856114.

    Read at: PubMed
  • Published on 12/18/2018

    Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci. 2019 Mar; 40(3):529-533. PMID: 30564964.

    Read at: PubMed
  • Published on 12/1/2018

    Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1091-1100. PMID: 30299493.

    Read at: PubMed
  • Published on 11/4/2018

    Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115. PMID: 30390709.

    Read at: PubMed
  • Published on 10/23/2018

    Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019 01 23; 692:204-209. PMID: 30366016.

    Read at: PubMed
  • Published on 10/5/2018

    Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au R, Qiu WQ. Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers. JAMA Netw Open. 2018 Oct 05; 1(6):e183597. PMID: 30646251.

    Read at: PubMed
  • Published on 9/7/2018

    Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 12; 136(6):955-972. PMID: 30194648.

    Read at: PubMed
  • Published on 9/1/2018

    Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768. PMID: 30053297.

    Read at: PubMed

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