Ronald J. Killiany, PhD

Associate Professor, Anatomy & Neurobiology

Ronald Killiany
617.638.8082
700 Albany St Ctr for Adv Biomed Res

Biography

The underlying theme of my research has been to explore structure – function relationships in the brain. To this end, my work has focused on uncovering the morphological changes in the brain that are responsible for the cognitive decline seen in aging and disease processes. In initial studies, I used developmental techniques to examine specific structure-function relationships in the memory system of non-human primates. I continued on to conduct studies of normal aging and cerebrovascular disease. In this work I have focused on characterize the cognitive changes taking place in non-human primate models. As my interests in studying the brain grew, I become involved in structural Magnetic Resonance Imaging (MRI) studies of normal aging and disorders such as Alzheimer’s disease. In this work I have been quantifying volumetric changes taking place in the brain in the course of the disease processes. This work continues to evolve and has changed focus somewhat in the recent years to include studies aimed at exploring the value of MRI in predicting which subjects will progress to develop cognitive decline and Alzheimer’s disease and which will remain cognitively stable.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Associate Professor, Environmental Health, Boston University School of Public Health

Education

  • Northeastern University, PhD
  • University of Hartford, MA
  • John Carroll University, BS

Classes Taught

Publications

  • Published on 11/13/2018

    Janulewicz P, Krengel M, Quinn E, Heeren T, Toomey R, Killiany R, Zundel C, Ajama J, O'Callaghan J, Steele L, Klimas N, Sullivan K. The Multiple Hit Hypothesis for Gulf War Illness: Self-Reported Chemical/Biological Weapons Exposure and Mild Traumatic Brain Injury. Brain Sci. 2018 Nov 13; 8(11). PMID: 30428552.

    Read at: PubMed
  • Published on 8/1/2018

    Taylor E, Huang N, Bodde J, Ellison A, Killiany R, Bachschmid MM, Hamilton J. MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits. J Transl Med. 2018 Aug 01; 16(1):215. PMID: 30068362.

    Read at: PubMed
  • Published on 4/26/2018

    Kubicki M, Baxi M, Pasternak O, Tang Y, Karmacharya S, Chunga N, Lyall AE, Rathi Y, Eckbo R, Bouix S, Mortazavi F, Papadimitriou G, Shenton ME, Westin CF, Killiany R, Makris N, Rosene DL. Lifespan Trajectories of White Matter Changes in Rhesus Monkeys. Cereb Cortex. 2018 Apr 26. PMID: 29701751.

    Read at: PubMed
  • Published on 2/6/2018

    Bauer CM, Cabral HJ, Killiany RJ. Multimodal Discrimination between Normal Aging, Mild Cognitive Impairment and Alzheimer's Disease and Prediction of Cognitive Decline. Diagnostics (Basel). 2018 Feb 06; 8(1). PMID: 29415470.

    Read at: PubMed
  • Published on 1/1/2018

    Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360. PMID: 29843242.

    Read at: PubMed
  • Published on 11/21/2017

    Farrar DC, Mian AZ, Budson AE, Moss MB, Killiany RJ. Functional brain networks involved in decision-making under certain and uncertain conditions. Neuroradiology. 2018 Jan; 60(1):61-69. PMID: 29164280.

    Read at: PubMed
  • Published on 11/6/2017

    Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J, Rahimpour Y, Puzo C, Healy RC, Martin B, Chaisson CE, Cantu RC, Au R, McClean M, McKee AC, Lin AP, Shenton ME, Killiany RJ, Stern RA. White matter signal abnormalities in former National Football League players. Alzheimers Dement (Amst). 2018; 10:56-65. PMID: 29201991.

    Read at: PubMed
  • Published on 10/18/2017

    Moore TL, Bowley B, Shultz P, Calderazzo S, Shobin E, Killiany RJ, Rosene DL, Moss MB. Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. Geroscience. 2017 12; 39(5-6):571-584. PMID: 29047012.

    Read at: PubMed
  • Published on 8/4/2017

    Koo BB, Michalovicz LT, Calderazzo S, Kelly KA, Sullivan K, Killiany RJ, O'Callaghan JP. Corticosterone potentiates DFP-induced neuroinflammation and affects high-order diffusion imaging in a rat model of Gulf War Illness. Brain Behav Immun. 2018 Jan; 67:42-46. PMID: 28782715.

    Read at: PubMed
  • Published on 7/10/2017

    Farrar DC, Mian AZ, Budson AE, Moss MB, Koo BB, Killiany RJ. Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity. Eur Radiol. 2018 Jan; 28(1):340-347. PMID: 28695358.

    Read at: PubMed

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