Orian S. Shirihai, MD, PhD

Adjunct Associate Professor, Medicine

Orian Shirihai
650 Albany St Evans Biomed Research Ctr


Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Boston Medical Center


  • Technion - Israel Institute of Technology, MD
  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, BSc


  • Published on 4/1/2019

    Liesa M, Van der Bliek A, Shirihai OS. To Fis or not to Fuse? This is the question! EMBO J. 2019 Apr 15; 38(8). PMID: 30936092.

    Read at: PubMed
  • Published on 3/21/2019

    Benador IY, Veliova M, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization. Cell Metab. 2019 Apr 02; 29(4):827-835. PMID: 30905670.

    Read at: PubMed
  • Published on 3/12/2019

    Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J. A Thermogenic-Like Brown Adipose Tissue Phenotype is Dispensable for Enhanced Glucose Tolerance in Female Mice. Diabetes. 2019 Mar 12. PMID: 30862679.

    Read at: PubMed
  • Published on 2/18/2019

    Salazar C, Elorza AA, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz LM. The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle. J Cell Physiol. 2019 Feb 18. PMID: 30779122.

    Read at: PubMed
  • Published on 1/30/2019

    Zeng J, Shirihai OS, Grinstaff MW. Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 Jan 30; e1801511. PMID: 30698920.

    Read at: PubMed
  • Published on 12/14/2018

    Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in ß cells under lipotoxicity. FASEB J. 2019 Mar; 33(3):4154-4165. PMID: 30550357.

    Read at: PubMed
  • Published on 12/4/2018

    Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. PMID: 30591411.

    Read at: PubMed
  • Published on 7/25/2018

    Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 10; 16:150-159. PMID: 30098928.

    Read at: PubMed
  • Published on 7/10/2018

    Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience. 2018 Jul 27; 5:99-109. PMID: 30240649.

    Read at: PubMed
  • Published on 6/28/2018

    Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. PMID: 29988332.

    Read at: PubMed

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