Orian S. Shirihai, MD, PhD

Adjunct Associate Professor, Medicine

617.230.8570
650 Albany St Evans Biomed Research Ctr

Biography

Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Boston Medical Center

Education

  • Technion - Israel Institute of Technology, MD
  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, BSc

Publications

  • Published on 4/9/2018

    Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A. Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J. 2018 Apr 09. PMID: 29632021.

    Read at: PubMed
  • Published on 4/3/2018

    Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 Apr 03; 27(4):869-885.e6. PMID: 29617645.

    Read at: PubMed
  • Published on 1/29/2018

    Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor a protects pancreatic ß-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 Mar 30; 293(13):4735-4751. PMID: 29378845.

    Read at: PubMed
  • Published on 11/15/2017

    Alsabeeh N, Chausse B, Kakimoto PA, Kowaltowski AJ, Shirihai O. Cell culture models of fatty acid overload: Problems and solutions. Biochim Biophys Acta. 2018 02; 1863(2):143-151. PMID: 29155055.

    Read at: PubMed
  • Published on 9/29/2017

    Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099. PMID: 28820316.

    Read at: PubMed
  • Published on 6/13/2017

    Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26):E5167-E5176. PMID: 28611221.

    Read at: PubMed
  • Published on 5/24/2017

    Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138. PMID: 28539390.

    Read at: PubMed
  • Published on 5/2/2017

    Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. PMID: 28467932.

    Read at: PubMed
  • Published on 3/1/2017

    Lim JA, Li L, Shirihai OS, Trudeau KM, Puertollano R, Raben N. Modulation of mTOR signaling as a strategy for the treatment of Pompe disease. EMBO Mol Med. 2017 Mar; 9(3):353-370. PMID: 28130275.

    Read at: PubMed
  • Published on 10/31/2016

    Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016 11 17; 539(7629):390-395. PMID: 27799657.

    Read at: PubMed

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