Expertise in carrying out metabolic research, writing grants and manuscripts. I also have experience in mentoring young investigators and working as a member of various national and international scientific groups. Finally, I have organized many multi-investigator research groups and scientific meetings.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Professor, Physiology & Biophysics, Boston University School of Medicine
- Active Staff Privileges, Endocrinology, Diabetes & Nutrition, Medicine, Boston Medical Center
- University of Pittsburgh, MD
- University of Oxford, DPhil
- Columbia College, BA
- Published on 5/16/2017
Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57. PMID: 28526426.
- Published on 9/27/2016
Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju SR, Joly E, Prentki M. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. Diabetologia. 2016 Dec; 59(12):2654-2663. PMID: 27677764.
- Published on 9/16/2016
Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3ß increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Oct; 36(5). PMID: 27534430.
- Published on 4/4/2016
Pepin É, Al-Mass A, Attané C, Zhang K, Lamontagne J, Lussier R, Madiraju SR, Joly E, Ruderman NB, Sladek R, Prentki M, Peyot ML. Pancreatic ß-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Ce, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression. PLoS One. 2016; 11(4):e0153017. PMID: 27043434.
- Published on 1/21/2016
Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75. PMID: 26797128.
- Published on 1/14/2016
Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism. 2016 May; 65(5):634-45. PMID: 27085772.
- Published on 10/1/2015
Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M. Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686. Diabetes. 2015 Oct; 64(10):e38-9. PMID: 26405280.
- Published on 5/22/2015
Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 2015 Sep; 64(9):3155-9. PMID: 26001396.
- Published on 5/21/2015
Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388. PMID: 25996822.
- Published on 3/23/2015
Brandon AE, Tid-Ang J, Wright LE, Stuart E, Suryana E, Bentley N, Turner N, Cooney GJ, Ruderman NB, Kraegen EW. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PLoS One. 2015; 10(3):e0121959. PMID: 25798922.
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