Muzhou Wu, PhD
Instructor, Dermatology
Biography
My research interests involve identifying the molecular basis for epigenetic alternations in melanoma development and progression using novel pharmacological inhibitors targeting specific epigenetic proteins using both in vitro and preclinical animal models of human disease. Additionally, I am seeking to develop quantitative tools utilizing critical molecular biomarkers, to predict patient responses to targeted epigenetic therapies, which will help to optimize therapeutic decision-making for a personalized approach to treatment of patients with advanced melanoma.
Websites
Education
- Stony Brook University, PhD
- University of Science and Technology of China (Teiching), BS
Publications
- Published on 1/4/2018
Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 01 04; 9(1):53. PMID: 29302039.
Read at: PubMed - Published on 1/1/2018
Eisenstein A, Chen E, Raghunathan R, Xu X, Wu M, McLean M, McGee J, Ryu B, Alani RM. Emerging Biomarkers in Cutaneous Melanoma. Molecular Diagnosis & Therapy. 2018.
- Published on 1/1/2015
Kalin J, Wu M, Gomez A, Hayward D, Adejola N, Wang L, Roberts J, Prusevich P, Hancock WW, Bradner JE, Mai A, Anders NM, Rudek MA, Ryu B, Alani RM, Mattevi A, Cole PA. CoREST in Peace: Dual Action Inhibitors of Histone Deacetylase and Lysine Specific Demethylase. The FASEB Journal. 2015; 29(1:723.8).
- Published on 2/4/2014
Magri L, Gacias M, Wu M, Swiss VA, Janssen WG, Casaccia P. c-Myc-dependent transcriptional regulation of cell cycle and nucleosomal histones during oligodendrocyte differentiation. Neuroscience. 2014 Sep 12; 276:72-86. PMID: 24502923.
Read at: PubMed - Published on 5/9/2012
Wu M, Hernandez M, Shen S, Sabo JK, Kelkar D, Wang J, O'Leary R, Phillips GR, Cate HS, Casaccia P. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci. 2012 May 09; 32(19):6651-64. PMID: 22573687.
Read at: PubMed - Published on 4/17/2012
Wu M, Nissen JC, Chen EI, Tsirka SE. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis. PLoS One. 2012; 7(4):e34933. PMID: 22529957.
Read at: PubMed - Published on 8/15/2009
Wu M, Tsirka SE. Endothelial NOS-deficient mice reveal dual roles for nitric oxide during experimental autoimmune encephalomyelitis. Glia. 2009 Aug 15; 57(11):1204-15. PMID: 19170181.
Read at: PubMed - Published on 7/16/2007
Bhasin M, Wu M, Tsirka SE. Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis. BMC Immunol. 2007 Jul 16; 8:10. PMID: 17634104.
Read at: PubMed