My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.
- Associate Professor, Biostatistics, Boston University School of Public Health
- VA Boston Healthcare System
- University of Iowa, PhD
- University of Iowa, MS
- University of Oregon, BS
- Published on 9/9/2017
Hayes JP, Hayes S, Miller DR, Lafleche G, Logue MW, Verfaellie M. Automated measurement of hippocampal subfields in PTSD: Evidence for smaller dentate gyrus volume. J Psychiatr Res. 2017 Dec; 95:247-252. PMID: 28923718.
- Published on 8/15/2017
Logue MW, Smith AK, Wolf EJ, Maniates H, Stone A, Schichman SA, McGlinchey RE, Milberg W, Miller MW. The correlation of methylation levels measured using Illumina 450K and EPIC BeadChips in blood samples. Epigenomics. 2017 Nov; 9(11):1363-1371. PMID: 28809127.
- Published on 7/28/2017
Hayes JP, Reagan A, Logue MW, Hayes SM, Sadeh N, Miller DR, Verfaellie M, Wolf EJ, McGlinchey RE, Milberg WP, Stone A, Schichman SA, Miller MW. BDNF genotype is associated with hippocampal volume in mild traumatic brain injury. Genes Brain Behav. 2017 Jul 28. PMID: 28755387.
- Published on 7/20/2017
Wolf EJ, Logue MW, Stoop TB, Schichman SA, Stone A, Sadeh N, Hayes JP, Miller MW. Accelerated DNA Methylation Age: Associations with PTSD and Mortality. Psychosom Med. 2017 Jul 20. PMID: 28731985.
- Published on 7/10/2017
Ratanatharathorn A, Boks MP, Maihofer AX, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M, Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC, Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ, Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA, Uddin M, Nievergelt CM, Smith AK. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep; 174(6):619-630. PMID: 28691784.
- Published on 4/25/2017
Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Largest GWAS of PTSD (N=20?070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2017 Apr 25. PMID: 28439101.
- Published on 4/4/2017
Sumner JA, Duncan LE, Wolf EJ, Amstadter AB, Baker DG, Beckham JC, Gelaye B, Hemmings S, Kimbrel NA, Logue MW, Michopoulos V, Mitchell KS, Nievergelt C, Rothbaum A, Seedat S, Shinozaki G, Vermetten E. Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits. Psychol Med. 2017 Aug; 47(11):2036-2039. PMID: 28374664.
- Published on 3/1/2017
Hayes JP, Logue MW, Sadeh N, Spielberg JM, Verfaellie M, Hayes SM, Reagan A, Salat DH, Wolf EJ, McGlinchey RE, Milberg WP, Stone A, Schichman SA, Miller MW. Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer's disease. Brain. 2017 Mar 01; 140(3):813-825. PMID: 28077398.
- Published on 3/1/2017
Hayes JP, Logue MW, Reagan A, Salat D, Wolf EJ, Sadeh N, Spielberg JM, Sperbeck E, Hayes SM, McGlinchey RE, Milberg WP, Verfaellie M, Stone A, Schichman SA, Miller MW. COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume. J Psychiatry Neurosci. 2017 Mar; 42(2):95-102. PMID: 28234210.
- Published on 2/7/2017
Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738. PMID: 28183528.
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