My research interest is to understand the cascade of intracellular events that leads to the activation of Wnt signaling and the biological role of the Wnt pathway during organ development and maintenance. We have two areas of interest:
Our first area of interest is to characterize the molecular mechanism leading to activation (stabilization and nuclear translocation) of ß-catenin, the key intracellular Wnt component that is activated in many human tumors. For this, we are using Xenopus embryos, mammalian cell lines, and mice ablated for CK2 catalytic subunits.
Our second area of interest is to characterize the cellular and molecular mechanisms regulated by Wnt/ß-catenin signaling during embryonic organ morphogenesis. For this we are using mice ablated for CK2 subunits and Xenopus embryos.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Boston Medical Center
- Universidad Autónoma de Madrid, PhD
- University of the Basque Country, MSc
- University of the Basque Country, BS
- Published on 4/29/2017
Lee M, Chea K, Pyda R, Chua M, Dominguez I. Comparative Analysis of Non-viral Transfection Methods in Mouse Embryonic Fibroblast Cells. J Biomol Tech. 2017 Jul; 28(2):67-74. PMID: 28507462.
- Published on 1/28/2017
Chua MM, Ortega CE, Sheikh A, Lee M, Abdul-Rassoul H, Hartshorn KL, Dominguez I. CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals (Basel). 2017 Jan 28; 10(1). PMID: 28134850.
- Published on 4/12/2016
Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M. Dominant-negative Ga subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease. Sci Signal. 2016 Apr 12; 9(423):ra37. PMID: 27072656.
- Published on 7/1/2015
Apfel J, Parikh JR, Reischmann P, Ewing RM, Müller O, Xia Y, Dominguez I. Systems Biology of Cancer Editor: Sam Thiagalingam. The Wnt signaling network in Cancer. Cambridge University Press. 2015.
- Published on 7/1/2015
Ortega C, Prince-Wright L, Dominguez I. Proceedings of the CK2-VII meeting. Editors Khalil Ahmed, Olaf Issinger and Ryszard Szyska. Role of CK2 in organ formation. 2015.
- Published on 12/26/2014
Ortega CE, Seidner Y, Dominguez I. Mining CK2 in cancer. PLoS One. 2014; 9(12):e115609. PMID: 25541719.
- Published on 4/16/2014
Siriwardana NS, Meyer R, Havasi A, Dominguez I, Panchenko MV. Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle. 2014; 13(12):1885-901. PMID: 24739512.
- Published on 10/4/2012
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci. 2013 Mar; 70(5):893-908. PMID: 23052206.
- Published on 8/17/2012
Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28; 111(8):1012-26. PMID: 22904094.
- Published on 5/5/2012
Imbrie GA, Wu H, Seldin DC, Dominguez I. Asymmetric Localization of CK2a During Xenopus Oogenesis. Hum Genet Embryol. 2012 May 05; Suppl 4(1):11328. PMID: 25346867.
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