Keith Tornheim, PhD
Associate Professor, Biochemistry & Cell Biology
Biography
Keith Tornheim, PhD, began his career at the Chobanian and Avedisian School of Medicine in 1981 as an assistant professor. Since then he has published over fifty articles, mainly on the topic of metabolism. He originally studied spontaneous oscillatory behavior of glycolysis in muscle extracts. Dr. Tornheim is currently in the Biochemistry teaching mission, teaching metabolism to first-year medical, dental and graduate students.
Other Positions
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Boston Medical Center
Websites
Education
- Brandeis University, PhD
- Antioch College, BS
Publications
- Published on 7/15/2012
Martínez-Costa OH, Sánchez V, Lázaro A, Hernández ED, Tornheim K, Aragón JJ. Distinct functional roles of the two terminal halves of eukaryotic phosphofructokinase. Biochem J. 2012 Jul 15; 445(2):213-8. PMID: 22530721.
Read at: PubMed - Published on 11/10/2009
Haller JF, Smith C, Liu D, Zheng H, Tornheim K, Han GS, Carman GM, Zoeller RA. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase. J Biol Chem. 2010 Jan 8; 285(2):866-77. PMID: 19903819.
Read at: PubMed - Published on 9/24/2009
Getty-Kaushik L, Viereck JC, Goodman JM, Guo Z, LeBrasseur NK, Richard AM, Flanagan JN, Yaney GC, Hamilton JA, Tornheim K. Mice deficient in phosphofructokinase-M have greatly decreased fat stores. Obesity (Silver Spring). 2010 Mar; 18(3):434-40. PMID: 19779479.
Read at: PubMed - Published on 6/26/2007
Richard AM, Webb DL, Goodman JM, Schultz V, Flanagan JN, Getty-Kaushik L, Deeney JT, Yaney GC, Dunaway GA, Berggren PO, Tornheim K. Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E794-801. PMID: 17595219.
Read at: PubMed - Published on 4/1/2007
Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205. PMID: 17181533.
Read at: PubMed - Published on 10/4/2004
Nascimben L, Ingwall JS, Lorell BH, Pinz I, Schultz V, Tornheim K, Tian R. Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension. 2004 Nov; 44(5):662-7. PMID: 15466668.
Read at: PubMed - Published on 8/12/2003
Juntti-Berggren L, Webb DL, Arkhammar PO, Schultz V, Schweda EK, Tornheim K, Berggren PO. Dihydroxyacetone-induced oscillations in cytoplasmic free Ca2+ and the ATP/ADP ratio in pancreatic beta-cells at substimulatory glucose. J Biol Chem. 2003 Oct 17; 278(42):40710-6. PMID: 12917415.
Read at: PubMed - Published on 7/1/2003
Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul; 52(7):1635-40. PMID: 12829626.
Read at: PubMed - Published on 1/1/2003
Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J. 2003 Jan 1; 369(Pt 1):173-8. PMID: 12356335.
Read at: PubMed - Published on 11/1/2002
Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE. Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E880-8. PMID: 12376314.
Read at: PubMed
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