As a clinical cardiac surgeon, I am frequently confronted with the problems of revascularization of the ischemic heart. Coronary artery bypass grafting is often employed to deliver new blood supply to the myocardium, but occasionally the anastomoses fail because of the development of neointimal hyperplasia and fibrosis where vessel connections are constructed. Using nanotechnology to deliver agents to the site of the anastomoses could be a game changer in terms of graft patency.
Transmyocardial laser revascularization of the heart has been shown to trigger neovascularization in underperfused regions of the myocardium not amenable to standard revascularization. The prospect of using nanotechnology to deliver growth factor or other agents in a targeted fashion to the area of the laser channels may help to achieve a quantum increase in the benefit realized from the laser surgery.
- Boston Medical Center
- Brown University School of Medicine, MD
- Brown University, MMS
- Brown University, AB
- Published on 7/2/2014
Lazar HL, Ketchedjian A, Haime M, Karlson K, Cabral H. Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1035-8; 1038-40. PMID: 25129595.
- Published on 10/1/1994
Dunton RF, Karlson KJ, Leonardi HK, Jenkins RL, Berger RL. Coronary artery bypass grafting in patients with transplanted livers. Ann Thorac Surg. 1994 Oct; 58(4):1054-8. PMID: 7944749.
- Published on 5/1/1994
Staples MH, Dunton RF, Karlson KJ, Leonardi HK, Berger RL. Heparin resistance after preoperative heparin therapy or intraaortic balloon pumping. Ann Thorac Surg. 1994 May; 57(5):1211-6. PMID: 8179387.
- Published on 4/1/1994
Berger RL, Dunton RF, Leonardi HK, Karlson KJ. Pack and close approach to persistent postcardiopulmonary bypass bleeding. J Am Coll Surg. 1994 Apr; 178(4):353-6. PMID: 8149034.
- Published on 12/1/1992
Dzik WH, Fleisher AG, Ciavarella D, Karlson KJ, Reed GE, Berger RL. Safety and efficacy of autologous blood donation before elective aortic valve operation. Ann Thorac Surg. 1992 Dec; 54(6):1177-80; discussion 1180-1. PMID: 1449306.
- Published on 5/1/1992
Berger RL, Karlson KJ, Dunton RF, Leonardi HK. Replacement of the thoracic aorta with intraluminal sutureless prosthesis. Ann Thorac Surg. 1992 May; 53(5):920-7. PMID: 1571002.
- Published on 4/1/1992
Berger RL, Dunton RF, Ashraf MM, Leonardi HK, Karlson KJ, Neptune WB. Thoracic surgery and the war against smoking: Richard H. Overholt, MD. Ann Thorac Surg. 1992 Apr; 53(4):719-25. PMID: 1554293.
- Published on 6/1/1991
Streitz JM, Karlson KJ. Complications of percutaneous dart therapy in management of pneumothorax. Chest. 1991 Jun; 99(6):1549-50. PMID: 2036856.
- Published on 11/1/1988
Karlson KJ, Ashraf MM, Berger RL. Rupture of left ventricle following mitral valve replacement. Ann Thorac Surg. 1988 Nov; 46(5):590-7. PMID: 3190341.
- Published on 6/1/1987
Karlson KJ, Brescia R, Najafi H. The healing characteristics of autogenous saphenous vein used in the reconstruction of previously implanted arterial saphenous vein grafts. Ann Thorac Surg. 1987 Jun; 43(6):648-52. PMID: 3592836.
View 1 more publications: View full profile at BUMC