Jason Randall Rock, PhD

Associate Professor, Medicine

Jason Rock
617.358.0798
670 Albany Street

Biography

Jason Rock, PhD, is an Associate Professor of Medicine at the Boston University School of Medicine. The Rock Lab int he Center for Regenerative Medicine studies how the many different cell types of our lungs are generated during development and how they respond to normal wear and tear, acute injury and disease. The underlying hypothesis is that aberrant (stem) cell behaviors explain many features of lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pulmonary fibrosis. We use in vivo and in vitro models to identify and test the progenitor capacity of putative stem cell populations and the molecular mechanisms and environmental influences (i.e., niches) that regulate their proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of lung disease.

Other Positions

  • Center for Regenerative Medicine, Boston University School of Medicine

Education

  • University of Florida College of Medicine, PhD

Publications

  • Published on 10/1/2019

    Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4). PMID: 31581513.

    Read at: PubMed
  • Published on 5/2/2019

    Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S. TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium. J Gen Physiol. 2019 Jul 01; 151(7):954-966. PMID: 31048412.

    Read at: PubMed
  • Published on 3/28/2019

    Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility. J Physiol. 2019 May; 597(9):2337-2360. PMID: 30843201.

    Read at: PubMed
  • Published on 3/12/2019

    Zawieja SD, Castorena JA, Gui P, Li M, Bulley SA, Jaggar JH, Rock JR, Davis MJ. Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels. J Gen Physiol. 2019 Apr 01; 151(4):532-554. PMID: 30862712.

    Read at: PubMed
  • Published on 5/23/2018

    Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. PMID: 29795293.

    Read at: PubMed
  • Published on 3/23/2018

    Sung TS, Hwang SJ, Koh SD, Bayguinov Y, Peri LE, Blair PJ, Webb TI, Pardo DM, Rock JR, Sanders KM, Ward SM. The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach. J Physiol. 2018 05 01; 596(9):1549-1574. PMID: 29430647.

    Read at: PubMed
  • Published on 12/7/2017

    Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. PMID: 29220665.

    Read at: PubMed
  • Published on 9/29/2017

    Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep. 2017 09 29; 7(1):12397. PMID: 28963502.

    Read at: PubMed
  • Published on 5/11/2017

    Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 Jul 06; 21(1):120-134.e7. PMID: 28506464.

    Read at: PubMed
  • Published on 5/2/2017

    Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017 Jun 01; 127(6):2277-2294. PMID: 28463226.

    Read at: PubMed

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