James A. Hamilton, PhD

Professor, Physiology & Biophysics

James Hamilton
(617) 638-5048
700 Albany St Ctr for Adv Biomed Res

Biography

Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Professor, Radiology, Boston University School of Medicine
  • Research Associate Professor, Biochemistry, Boston University School of Medicine
  • Research Associate Professor, General Internal Medicine, Medicine, Boston University School of Medicine
  • Boston Medical Center

Education

  • Indiana University Bloomington, PhD
  • Juniata College, BS

Publications

  • Published on 11/6/2017

    Hamilton JA, Hasturk H, Kantarci A, Serhan CN, Van Dyke T. Atherosclerosis, Periodontal Disease, and Treatment with Resolvins. Curr Atheroscler Rep. 2017 Nov 06; 19(12):57. PMID: 29110146.

    Read at: PubMed
  • Published on 8/1/2017

    Hua N, Takahashi H, Yee GM, Kitajima Y, Katagiri S, Kojima M, Anzai K, Eguchi Y, Hamilton JA. Influence of muscle fiber type composition on early fat accumulation under high-fat diet challenge. PLoS One. 2017; 12(8):e0182430. PMID: 28763507.

    Read at: PubMed
  • Published on 5/1/2017

    Stein-Merlob AF, Hara T, McCarthy JR, Mauskapf A, Hamilton JA, Ntziachristos V, Libby P, Jaffer FA. Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging. Circ Cardiovasc Imaging. 2017 May; 10(5). PMID: 28487316.

    Read at: PubMed
  • Published on 10/13/2016

    Jay AG, Hamilton JA. Disorder Amidst Membrane Order: Standardizing Laurdan Generalized Polarization and Membrane Fluidity Terms. J Fluoresc. 2017 Jan; 27(1):243-249. PMID: 27738919.

    Read at: PubMed
  • Published on 5/20/2016

    Jay AG, Hamilton JA. The enigmatic membrane fatty acid transporter CD36: New insights into fatty acid binding and their effects on uptake of oxidized LDL. Prostaglandins Leukot Essent Fatty Acids. 2016 May 20. PMID: 27288302.

    Read at: PubMed
  • Published on 11/14/2015

    Pham TA, Hua N, Phinikaridou A, Killiany R, Hamilton J. Early in vivo discrimination of vulnerable atherosclerotic plaques that disrupt: A serial MRI study. Atherosclerosis. 2016 Jan; 244:101-7. PMID: 26606442.

    Read at: PubMed
  • Published on 10/8/2015

    Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833. PMID: 26448434.

    Read at: PubMed
  • Published on 3/19/2015

    Hasturk H, Abdallah R, Kantarci A, Nguyen D, Giordano N, Hamilton J, Van Dyke TE. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1123-33. PMID: 25792445.

    Read at: PubMed
  • Published on 1/1/2015

    Jay AG, Chen AN, Paz MA, Hung JP, Hamilton JA. CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding. J Biol Chem. 2015 Feb 20; 290(8):4590-603. PMID: 25555908.

    Read at: PubMed
  • Published on 8/8/2014

    Papadopoulos G, Kramer CD, Slocum CS, Weinberg EO, Hua N, Gudino CV, Hamilton JA, Genco CA. A mouse model for pathogen-induced chronic inflammation at local and systemic sites. J Vis Exp. 2014; (90):e51556. PMID: 25146644.

    Read at: PubMed

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