Ivana Delalle, MD, PhD

Associate Professor, Pathology & Laboratory Medicine

Ivana Delalle
(617) 414-7014
72 E. Concord St Instructional (L)

Biography

I. During the progression of AD, hippocampal neurons show degenerative as well as regenerative changes, possibly influenced by the set of molecular regulators that may modify brain reserve, the ability of brain to tolerate pathological changes in AD before manifesting clinical signs and symptoms. My group hypothesizes that expression of these molecules in the hippocampal neurons will correlate with the cognitive function of the participants of the Framingham Heart Study.
II. Small non-coding RNA molecules (microRNAs, miRNAs) are known to regulate genes involved in brain functions negatively affected in neuropsychiatric disorders. My group hypothesizes that exosomes, secretory vesicles recently shown to comprise miRNAs, harbor differential miRNA content in the postmortem brain tissue of patients diagnosed with either bipolar disorder (BD) or schizophrenia (SCH), or of normal controls. The results of our analysis may help elucidate neuropathological mechanisms underlying BD and SCH as well as identify biological markers for BD and SCH.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Associate Professor, Neurology, Boston University School of Medicine

Education

  • University of Zagreb, MD
  • University of Zagreb, PhD

Publications

  • Published on 8/2/2017

    Agís-Balboa RC, Pinheiro PS, Rebola N, Kerimoglu C, Benito E, Gertig M, Bahari-Javan S, Jain G, Burkhardt S, Delalle I, Jatzko A, Dettenhofer M, Zunszain PA, Schmitt A, Falkai P, Pape JC, Binder EB, Mulle C, Fischer A, Sananbenesi F. Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia. EMBO J. 2017 Oct 02; 36(19):2815-2828. PMID: 28768717.

    Read at: PubMed
  • Published on 7/1/2017

    Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE, O'Rourke R, Pinches N, Ho P, Malkin H, Sinai C, Filbin M, Plant A, Bi WL, Chang MS, Yang E, Wright KD, Manley PE, Ducar M, Alexandrescu S, Lidov H, Delalle I, Goumnerova LC, Church AJ, Janeway KA, Harris MH, MacConaill LE, Folkerth RD, Lindeman NI, Stiles CD, Kieran MW, Ligon AH, Santagata S, Dubuc AM, Chi SN, Beroukhim R, Ligon KL. Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996. PMID: 28104717.

    Read at: PubMed
  • Published on 5/22/2017

    Bahari-Javan S, Varbanov H, Halder R, Benito E, Kaurani L, Burkhardt S, Anderson-Schmidt H, Anghelescu I, Budde M, Stilling RM, Costa J, Medina J, Dietrich DE, Figge C, Folkerts H, Gade K, Heilbronner U, Koller M, Konrad C, Nussbeck SY, Scherk H, Spitzer C, Stierl S, Stöckel J, Thiel A, von Hagen M, Zimmermann J, Zitzelsberger A, Schulz S, Schmitt A, Delalle I, Falkai P, Schulze TG, Dityatev A, Sananbenesi F, Fischer A. HDAC1 links early life stress to schizophrenia-like phenotypes. Proc Natl Acad Sci U S A. 2017 Jun 06; 114(23):E4686-E4694. PMID: 28533418.

    Read at: PubMed
  • Published on 2/12/2017

    Choi JL, Kao PF, Itriago E, Zhan Y, Kozubek JA, Hoss AG, Banigan MG, Vanderburg CR, Rezvani AH, Latourelle JC, Cabral H, Delalle I. miR-149 and miR-29c as candidates for bipolar disorder biomarkers. Am J Med Genet B Neuropsychiatr Genet. 2017 Apr; 174(3):315-323. PMID: 28190298.

    Read at: PubMed
  • Published on 1/1/2017

    Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients. J Alzheimers Dis. 2017; 60(1):43-56. PMID: 28777754.

    Read at: PubMed
  • Published on 6/26/2016

    Adams SL, Tilton K, Kozubek JA, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016 Aug; 75(8):779-790. PMID: 27346750.

    Read at: PubMed
  • Published on 4/12/2016

    Šimic G, Babic Leko M, Wray S, Harrington CR, Delalle I, Jovanov-Miloševic N, Bažadona D, Buée L, de Silva R, Di Giovanni G, Wischik CM, Hof PR. Monoaminergic neuropathology in Alzheimer's disease. Prog Neurobiol. 2017 Apr; 151:101-138. PMID: 27084356.

    Read at: PubMed
  • Published on 2/25/2016

    Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22. PMID: 26924435.

    Read at: PubMed
  • Published on 1/6/2016

    Šimic G, Babic Leko M, Wray S, Harrington C, Delalle I, Jovanov-Miloševic N, Bažadona D, Buée L, de Silva R, Di Giovanni G, Wischik C, Hof PR. Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies. Biomolecules. 2016 Jan 06; 6(1):6. PMID: 26751493.

    Read at: PubMed
  • Published on 4/10/2014

    Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-dependent p25 generation regulates synaptic plasticity and Aß-induced cognitive impairment. Cell. 2014 Apr 10; 157(2):486-98. PMID: 24725413.

    Read at: PubMed

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