Giuseppina A. Farina, MD, PhD

Research Assistant Professor, Medicine

(617) 638-4307
75 E. Newton St Evans Building

Biography

I have a broad background in clinical and research activities, with specific training and expertise in key research areas for this application. As a postdoctoral fellow I have focused my attention on translational studies, bridging clinical problems in scleroderma with molecular pathogenesis of skin, pulmonary hypertension and pulmonary fibrosis

Education

  • University of Rome, MD
  • University of Rome, PhD
  • University of Rome, BS

Publications

  • Published on 2/28/2017

    Farina A, Peruzzi G, Lacconi V, Lenna S, Quarta S, Rosato E, Vestri AR, York M, Dreyfus DH, Faggioni A, Morrone S, Trojanowska M, Farina GA. Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes. Arthritis Res Ther. 2017 Feb 28; 19(1):39. PMID: 28245863.

    Read at: PubMed
  • Published on 1/1/2016

    Farina A, Farina GA. Fresh Insights into Disease Etiology and the Role of Microbial Pathogens. Curr Rheumatol Rep. 2016 Jan; 18(1):1. PMID: 26700911.

    Read at: PubMed
  • Published on 12/16/2015

    Lenna S, Assassi S, Farina GA, Mantero JC, Scorza R, Lafyatis R, Farber HW, Trojanowska M. The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients. Arthritis Res Ther. 2015; 17:363. PMID: 26669670.

    Read at: PubMed
  • Published on 6/22/2015

    Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest. 2015 Jul 1; 125(7):2795-807. PMID: 26098215.

    Read at: PubMed
  • Published on 12/18/2013

    van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30; 370(5):433-43. PMID: 24350901.

    Read at: PubMed
  • Published on 10/11/2013

    Farina A, Cirone M, York M, Lenna S, Padilla C, McLaughlin S, Faggioni A, Lafyatis R, Trojanowska M, Farina GA. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Invest Dermatol. 2014 Apr; 134(4):954-64. PMID: 24129067.

    Read at: PubMed
  • Published on 7/19/2013

    Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R. Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin. Ann Rheum Dis. 2014 Oct; 73(10):1864-72. PMID: 23873879.

    Read at: PubMed
  • Published on 2/18/2013

    Lenna S, Chrobak I, Farina GA, Rodriguez-Pascual F, Lamas S, Lafyatis R, Scorza R, Trojanowska M. HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One. 2013; 8(2):e56123. PMID: 23441162.

    Read at: PubMed
  • Published on 1/10/2013

    Ghosh AK, Bhattacharyya S, Lafyatis R, Farina G, Yu J, Thimmapaya B, Wei J, Varga J. p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-ß: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol. 2013 May; 133(5):1302-10. PMID: 23303459.

    Read at: PubMed
  • Published on 1/11/2012

    Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO. Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol. 2012 Mar; 180(3):1080-94. PMID: 22245215.

    Read at: PubMed

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