Douglas L. Rosene, PhD
Professor, Anatomy & Neurobiology
Biography
My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.
Other Positions
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Rochester, PhD
- Stanford University, AB
Classes Taught
- GMSAN702
- GMSAN810
- GMSNE700
- GRSBI755
Publications
- Published on 3/21/2024
Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Res Sq. 2024 Mar 21. PMID: 38562721.
Read at: PubMed - Published on 1/8/2024
Amaral DG, Augustinack J, Barbas H, Frosch M, Gabrieli J, Luebke J, Rakic P, Rosene D, Rushmore RJ. The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive. Hippocampus. 2024 Feb; 34(2):52-57. PMID: 38189522.
Read at: PubMed - Published on 12/7/2023
Vogt BA, Rosene DL. Comparison of monkey and human retrosplenial neurocytology. J Comp Neurol. 2023 Dec; 531(18):2044-2061. PMID: 38062543.
Read at: PubMed - Published on 11/22/2023
DeVries SA, Conner B, Dimovasili C, Moore TL, Medalla M, Mortazavi F, Rosene DL. Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment. Geroscience. 2024 Apr; 46(2):2503-2519. PMID: 37989825.
Read at: PubMed - Published on 11/2/2023
Bautista J, García-Cabezas MÁ, Medalla M, Rosene DL, Zikopoulos B, Barbas H. Pattern of ventral temporal lobe interconnections in rhesus macaques. J Comp Neurol. 2023 Dec; 531(18):1963-1986. PMID: 37919833.
Read at: PubMed - Published on 11/1/2023
He S, Guan Y, Cheng CH, Moore TL, Luebke JI, Killiany RJ, Rosene DL, Koo BB, Ou Y. Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age. Front Aging Neurosci. 2023; 15:1249415. PMID: 38020785.
Read at: PubMed - Published on 9/2/2023
Zhou Y, Bhatt H, Mojica CA, Xin H, Pessina MA, Rosene DL, Moore TL, Medalla M. Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys. J Neuroinflammation. 2023 Sep 02; 20(1):201. PMID: 37660145.
Read at: PubMed - Published on 5/15/2023
Zhou Y, Bhatt H, Mojica CA, Xin H, Pessina M, Rosene DL, Moore TL, Medalla M. Mesenchymal-Derived Extracellular Vesicles Enhance Microglia-mediated Synapse Remodeling after Cortical Injury in Rhesus Monkeys. Res Sq. 2023 May 15. PMID: 37292805.
Read at: PubMed - Published on 4/28/2023
Moore TL, Medalla M, Ibañez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. Geroscience. 2023 Jun; 45(3):1317-1342. PMID: 37106282.
Read at: PubMed - Published on 4/6/2023
Welke LA, Moore TL, Rosene DL, Killiany RJ, Moss MB. Prefrontal and medial temporal interactions in memory functions in the rhesus monkey. Behav Neurosci. 2023 Jun; 137(3):211-222. PMID: 37023305.
Read at: PubMed
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