Dr. David Henderson is a leader in the fields of schizophrenia, medical co-morbidity, and global psychiatry. He directs the Chester Pierce Division of Global Psychiatry and the MGH Schizophrenia Clinical and Research Program (SCRP) and is principal investigator and director of the MGH Global Mental Health Clinical Research Fellowship.
His research interests include treatment-resistant schizophrenia, the use of psychopharmacological and antipsychotic agents in the treatment of schizophrenia, and the impact of antipsychotic agents on weight, cardiovascular disease, and lipid and glucose metabolism. Dr. Henderson noticed a high rate of diabetes mellitus (DM) in his clozapine-treated patients. As a result, he developed procedures for screening and early detection of diabetes in this population. Dr. Henderson focused on metabolic effects of atypical antipsychotic agents, the role of serotonin receptors, and augmentation strategies to reduce or reverse metabolic disturbances.
As Director of the SCRP, Dr. Henderson directs a leading center for the study and treatment of schizophrenia worldwide. SCRP combines clinical care, training, and clinical and neuroimaging research, with programs designed to improve long-term health and quality of life of seriously mentally ill patients though a multidisciplinary, collaborative approach with community agencies. ]SCRP has more than 20 studies and clinical trials and has trained numerous clinical researchers, fellows and residents who have pursued successful careers in academic medicine. SCRP consults in diabetes and weight management (Dr. Henderson’s current research area), psychosocial therapy, first-episode psychosis, smoking cessation and other psychosis-related issues.
- Chair, Psychiatry, Boston University School of Medicine
- Assistant Dean, Diversity & Multicultural Affairs, Boston University School of Medicine
- University of Massachusetts Medical School, MD
- Tufts University, BS
- Published on 1/1/2019
Oppenheim CE, Axelrod K, Menyongai J, Chukwuezi B, Tam A, Henderson DC, Borba CPC. The HEAAL Project: Applying Community-Based Participatory Research (CBPR) Methodology in a Health and Mental Health Needs Assessment With an African Immigrant and Refugee Faith Community in Lowell, Massachusetts. J Public Health Manag Pract. 2019 Jan/Feb; 25(1):E1-E6. PMID: 30507809.
- Published on 12/1/2018
Levey EJ, Laird LD, Becker AE, Harris BL, Lekpeh GG, Oppenheim CE, Henderson DC, Borba CPC. Narratives of Agency and Capability from Two Adolescent Girls in Post-conflict Liberia. Cult Med Psychiatry. 2018 Dec; 42(4):947-979. PMID: 30076558.
- Published on 11/13/2018
Pino EC, Zuo Y, Borba CP, Henderson DC, Kalesan B. Reply to psychiatric disorders' paradoxical protective effect on cardiovascular procedures and mortality. Psychiatry Res. 2018 Nov 13. PMID: 30470578.
- Published on 3/20/2018
Pino EC, Zuo Y, Borba CPC, Henderson DC, Kalesan B. Clinical depression and anxiety among ST-elevation myocardial infarction hospitalizations: Results from Nationwide Inpatient Sample 2004-2013. Psychiatry Res. 2018 08; 266:291-300. PMID: 29615266.
- Published on 3/15/2018
Petruzzi LJ, Pullen SJ, Lange BCL, Parnarouskis L, Dominguez S, Harris B, Quiterio N, Lekpeh G, Manobah B, Henderson DC, Borba CPC. Contributing Risk Factors for Substance Use Among Youth in Postconflict Liberia. Qual Health Res. 2018 Oct; 28(12):1827-1838. PMID: 29542398.
- Published on 3/9/2018
Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, Öngür D. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol Psychiatry. 2018 Mar 09. PMID: 29523870.
- Published on 11/23/2017
Jackson JW, Fulchino L, Rogers J, Mogun H, Polinski J, Henderson DC, Schneeweiss S, Fischer MA. "Impact of drug-reimbursement policies on prescribing: A case-study of a newly marketed long-acting injectable antipsychotic among relapsed schizophrenia patients". Pharmacoepidemiol Drug Saf. 2018 Jan; 27(1):95-104. PMID: 29168261.
- Published on 11/22/2017
Nemani KL, Greene MC, Ulloa M, Vincenzi B, Copeland PM, Al-Khadari S, Henderson DC. Clozapine, Diabetes Mellitus, Cardiovascular Risk and Mortality: Results of a 21-year Naturalistic Study in Patients with Schizophrenia and Schizoaffective Disorder. Clin Schizophr Relat Psychoses. 2017 Nov 22. PMID: 29164928.
- Published on 11/21/2017
Halim N, Beard J, Mesic A, Patel A, Henderson D, Hibberd P. Intimate partner violence during pregnancy and perinatal mental disorders in low and lower middle income countries: A systematic review of literature, 1990-2017. Clin Psychol Rev. 2018 Dec; 66:117-135. PMID: 29198412.
- Published on 11/2/2017
Denckla CA, Consedine NS, Spies G, Cherner M, Henderson DC, Koenen KC, Seedat S. Associations between neurocognitive functioning and social and occupational resilience among South African women exposed to childhood trauma. Eur J Psychotraumatol. 2017; 8(1):1394146. PMID: 29163865.
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