Ci-Di D. Chen, PhD

Research Associate Professor, Biochemistry

Ci-Di Chen
72 E. Concord St Silvio Conte (K)


I am interested in the research of normal brain aging and Alzheimer’s disease. My research interests are the mechanisms of the anti-aging protein, Klotho functions in the brain. My research is aimed to 1) Discovery of Klotho enhancing compounds. 2) Study the structure function of Klotho and identify the proteases responsible for Klotho shedding. 3) Decipher the role of Klotho in brain aging and identify the receptor for this anti-aging gene. 4) Study the mechanisms of Klotho effects on myelination. 5) Lowering Abeta production with a small molecular inhibitor of Alzheimer’s precursor protein dimerization.


  • University of Illinois at Urbana–Champaign, PhD
  • University of Illinois at Urbana–Champaign, MS
  • National Institute of Biological Sciences (NIBS), MS
  • National Taiwan University, BS


  • Published on 1/19/2018

    Chen CD, Zeldich E, Li Y, Yuste A, Abraham CR. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. J Mol Neurosci. 2018 Feb; 64(2):175-184. PMID: 29352444.

    Read at: PubMed
  • Published on 3/22/2016

    Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. Vitam Horm. 2016; 101:215-38. PMID: 27125744.

    Read at: PubMed
  • Published on 6/12/2015

    Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination. J Mol Neurosci. 2015 Oct; 57(2):185-96. PMID: 26067431.

    Read at: PubMed
  • Published on 8/20/2014

    Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014 Sep 2; 53(34):5579-87. PMID: 25110992.

    Read at: PubMed
  • Published on 7/29/2014

    Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92. PMID: 25043464.

    Read at: PubMed
  • Published on 7/18/2014

    Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29; 289(35):24700-15. PMID: 25037225.

    Read at: PubMed
  • Published on 6/8/2014

    Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci. 2015 Jan; 55(1):76-90. PMID: 24907942.

    Read at: PubMed
  • Published on 3/8/2013

    So PP, Khodr CE, Chen CD, Abraham CR. Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants. Am J Neurodegener Dis. 2013; 2(1):15-28. PMID: 23515184.

    Read at: PubMed
  • Published on 1/30/2013

    Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39. PMID: 23365232.

    Read at: PubMed
  • Published on 1/1/2012

    So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87. PMID: 22822474.

    Read at: PubMed

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