Christopher V. Gabel, PhD

Associate Professor, Physiology & Biophysics

Christopher Gabel
(617) 638-4390
72 E. Concord St Instructional (L)

Biography

Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Other Positions

  • Associate Professor, Pharmacology & Experimental Therapeutics, Boston University School of Medicine

Education

  • Harvard University, PhD
  • Princeton University, BA

Publications

  • Published on 2/8/2017

    Melentijevic I, Toth ML, Arnold ML, Guasp RJ, Harinath G, Nguyen KC, Taub D, Parker JA, Neri C, Gabel CV, Hall DH, Driscoll M. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature. 2017 02 16; 542(7641):367-371. PMID: 28178240.

    Read at: PubMed
  • Published on 12/21/2016

    Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21; 92(6):1294-1307. PMID: 28009275.

    Read at: PubMed
  • Published on 4/12/2016

    Chung SH, Awal MR, Shay J, McLoed MM, Mazur E, Gabel CV. Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):E2852-60. PMID: 27078101.

    Read at: PubMed
  • Published on 10/29/2015

    Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19. PMID: 26526391.

    Read at: PubMed
  • Published on 9/17/2015

    He S, Philbrook A, McWhirter R, Gabel CV, Taub DG, Carter MH, Hanna IM, Francis MM, Miller DM. Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein. Curr Biol. 2015 Oct 5; 25(19):2541-8. PMID: 26387713.

    Read at: PubMed
  • Published on 11/26/2014

    Sun L, Shay J, McLoed M, Roodhouse K, Chung SH, Clark CM, Pirri JK, Alkema MJ, Gabel CV. Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation. J Neurosci. 2014 Nov 26; 34(48):15947-56. PMID: 25429136.

    Read at: PubMed
  • Published on 10/30/2014

    Gruner M, Nelson D, Winbush A, Hintz R, Ryu L, Chung SH, Kim K, Gabel CV, van der Linden AM. Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs. PLoS Genet. 2014 Oct; 10(10):e1004707. PMID: 25357003.

    Read at: PubMed
  • Published on 7/18/2013

    Chung SH, Schmalz A, Ruiz RC, Gabel CV, Mazur E. Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development. Cell Rep. 2013 Jul 25; 4(2):316-26. PMID: 23871668.

    Read at: PubMed
  • Published on 4/10/2013

    Chung SH, Sun L, Gabel CV. In vivo neuronal calcium imaging in C. elegans. J Vis Exp. 2013; (74). PMID: 23603812.

    Read at: PubMed
  • Published on 4/1/2013

    Reina CP, Driscoll M, Gabel CV. Neuronal repair: Apoptotic proteins make good. Worm. 2013 Apr 1; 2(2):e22285. PMID: 24058867.

    Read at: PubMed

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