Gene regulation by RNA and chromatin
Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.
- University of Massachusetts Amherst, PhD
- Published on 3/30/2014
Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014 Apr; 21(4):358-65. PMID: 24681887.
- Published on 2/20/2014
Kennedy LM, Grishok A. Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics. 2014 May; 197(1):207-20. PMID: 24558261.
- Published on 12/17/2013
Cecere G, Grishok A. A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta. 2014 Mar; 1839(3):223-33. PMID: 24361586.
- Published on 8/29/2013
Kennedy LM, Pham SC, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013 Sep 12; 4(5):996-1009. PMID: 23994474.
- Published on 6/27/2013
Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell. 2013 Jun 27; 50(6):894-907. PMID: 23806335.
- Published on 1/1/2013
Grishok A. Biology and Mechanisms of Short RNAs in Caenorhabditis elegans. Adv Genet. 2013; 83:1-69. PMID: 23890211.
- Published on 12/21/2012
Avgousti DC, Cecere G, Grishok A. The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans. Mol Cell Biol. 2013 Mar; 33(5):999-1015. PMID: 23263989.
- Published on 8/3/2012
Avgousti DC, Palani S, Sherman Y, Grishok A. CSR-1 RNAi pathway positively regulates histone expression in C. elegans. EMBO J. 2012 Oct 3; 31(19):3821-32. PMID: 22863779.
- Published on 7/19/2012
Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A. Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Mol Cell. 2012 Sep 14; 47(5):734-45. PMID: 22819322.
- Published on 4/1/2012
Grishok A. Endogenous RNAi and adaptation to environment in C. elegans. Worm. 2012 Apr 1; 1(2):129-33. PMID: 24058837.
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