A. R. Frackelton, PhD

Research Associate Professor, Medicine

(617) 638-8797

Other Positions

  • Roger Williams Medical Center


  • Brown University, PhD
  • University of Connecticut, MS
  • University of Connecticut, BA


  • Published on 4/2/2009

    Quinn JA, Graeber CT, Frackelton AR, Kim M, Schwarzbauer JE, Filardo EJ. Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. Mol Endocrinol. 2009 Jul; 23(7):1052-64. PMID: 19342448.

    Read at: PubMed
  • Published on 10/1/2007

    Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR, Hafer LJ. p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. Clin Cancer Res. 2007 Oct 1; 13(19):5798-804. PMID: 17908971.

    Read at: PubMed
  • Published on 6/20/2006

    Wanebo HJ, Frackelton AR, Hafer LJ, Bagdasaryan R, Lis R, Sabo E, Resnick MB. Shc test as a strong prognostic indicator of disease outcome in early stage gastric cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10090. PMID: 27954030.

    Read at: PubMed
  • Published on 1/1/2006

    Frackelton AR, Lu L, Davol PA, Bagdasaryan R, Hafer LJ, Sgroi DC. p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy. Breast Cancer Res. 2006; 8(6):R73. PMID: 17196107.

    Read at: PubMed
  • Published on 10/15/2003

    Davol PA, Bagdasaryan R, Elfenbein GJ, Maizel AL, Frackelton AR. Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer. Cancer Res. 2003 Oct 15; 63(20):6772-83. PMID: 14583473.

    Read at: PubMed
  • Published on 1/1/2002

    Filardo EJ, Quinn JA, Frackelton AR, Bland KI. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol. 2002 Jan; 16(1):70-84. PMID: 11773440.

    Read at: PubMed
  • Published on 7/1/2001

    Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR. Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells. Cell Growth Differ. 2001 Jul; 12(7):379-86. PMID: 11457735.

    Read at: PubMed
  • Published on 10/1/2000

    Filardo EJ, Quinn JA, Bland KI, Frackelton AR. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 2000 Oct; 14(10):1649-60. PMID: 11043579.

    Read at: PubMed
  • Published on 6/1/2000

    Boney CM, Gruppuso PA, Faris RA, Frackelton AR. The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes. Mol Endocrinol. 2000 Jun; 14(6):805-13. PMID: 10847583.

    Read at: PubMed
  • Published on 11/1/1999

    Davol PA, Garza S, Frackelton AR. Combining suramin and a chimeric toxin directed to basic fibroblast growth factor receptors increases therapeutic efficacy against human melanoma in an animal model. Cancer. 1999 Nov 1; 86(9):1733-41. PMID: 10547546.

    Read at: PubMed

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