Past Faculty Members
Basic Science Investigators
Charles R. Cantor, Ph.D.
Director of the Center for Advanced Biotechnology, and Professor of Biomedical Engineering and Pharmacology of Experimental Therapeutics, Dr. Cantor’s honors and awards include: Fellow of the Alfred P. Sloan Foundation, Fresenius Award in Chemistry, Guggenheim Fellow, Fairchild Distinguished Visiting Scholar at the California Institute of Technology, the Eli Lilly Award in Biological Chemistry, an Outstanding Investigator Grant from the National Cancer Institute, the Biochemical Analysis Prize of the German Society of Clinical Chemistry, the ISCO Award for Advances in Biochemical Instrumentation, the Sober Prize of the American Society for Biochemistry and Molecular Biology, and the Emily Gray award from the Biophysical Society. He is a Member of the National Academy of Sciences, a Fellow of the American Association for the Advancement of Science, a Member of the American Academy of Arts and Sciences, and an honorary member of the Biochemical Society of Japan. Dr. Cantor served as the Principal Scientist of the Human Genome Project from 1990-1992. He has served on numerous editorial boards, Government review committees, and industrial advisory committees.
Judith Ann Foster, Ph.D.
A professor of biochemistry and research professor of medicine, her research concerns the regulation of elastic fiber synthesis in the development and repair of pulmonary and cardiovascular tissues. Elastic fibers play a key functional role in maintaining the essential elasticity of alveolar and arterial walls. In vivo destruction of these fibers is a significant factor in the pathogenesis of atherosclerosis and pulmonary emphysema. An important approach to understanding disease processes that alter elastic fibers is to develop in vivo cell culture models which mimic disease abnormalities in a defined and controlled environment. These cell models (aortic smooth muscle cells and pulmonary interstitial fibroblasts) can be used to define specific molecular events involved in the cellular response to injury and subsequent repair processes. Insight into transcriptional, post-transcriptional, translational, and post-translational mechanisms accompanying cell responses can lead to the design of credible intervention strategies pertinent to clinical applications.
Peter B. O¡¯Connor, Ph.D.
An assistant professor of biochemistry, is the assistant director of the BUSM Mass Spectrometry Resource, and project leader for Cryogenic FTMS development within the BUSM Cardiovascular Proteomics Center. Dr. O¡¯Connor studies mass spectrometry methods and instrumentation for proteomics and glycomics analysis of cardiovascular systems. The primary focus is on developing and improving the ability to use high performance matrix assisted laser desorption/ionization to ionize tryptic digest mixtures of relevant isolated proteins and use fourier transform mass spectrometry to generate high performance mass spectra for identifying the proteins and sites of their posttranslational modifications in a highly automated fashion. Of particular interest and relevance in cardiovascular proteomics is the process known as ¡°oxidative stress,¡± which involves free-radical modification of proteins. High performance mass spectrometry has the ability to determine exactly the structure of these modifications, which can be correlated with what is known from gas phase free radical reactions induced by electron capture dissociation.
An associate professor of medicine, he is Director of Clinical Cardiology, Director of Echocardiography and Co-Director of Non-Invasive Cardiology. Dr. Davidoff has received numerous teaching awards including the Stanley L. Robbins in 1994 from Boston University School of Medicine, and has twice received the “Excellence in Teaching Award” from the Department of Medicine. His research interests relate to the interaction between LV geometry and function, and he has utilized echocardiography to explore these features in multicenter studies of myocarditis and cardiogenic shock. He is presently using echocardiographic techniques to evaluate diastolic function in patients with cardiac amyloidosis as well as in patients after cardiac surgery. He is Chair of the Education Steering Committee of the American Society of Echocardiography.
Harold L. Lazar, M.D.
A professor of cardiothoracic surgery and Director of the Cardiothoracic Surgical Laboratories at the Boston University School of Medicine, he is the author of over 130 peer review articles and has edited a book on Current Therapy for Acute Coronary Ischemia. He has served as Chairman of the Massachusetts Consortium for Lung Transplantation, Secretary of the Section on Cardiac Surgery for The American College of Chest Physicians, and the Merit Review Committee for Surgery in the Department of Veteran’s Affairs. He is currently a member of the National Peer Review Committee for Surgery for The American Heart Association and serves on The Editorial Boards of The Journal of Thoracic and Cardiovascular Surgery, The Journal of Cardiac Surgery, and Cardiology Review. His research interests include myocardial protection during cardiac surgery, reversal of reperfusion injury during acute coronary revascularization, and mechanisms to alter inflammatory injury during cardiac surgery. He is the recipient of a grant from The American Diabetic Association to study the effects of Glucose-insulin-potassium solutions during CABG surgery in diabetic patients.
William B. Kannel, M.D.
A professor of medicine and public health, he is also a fellow of the American College of Epidemiology and the American College of Preventive Medicine (honorary). He has been active in the field of cardiovascular epidemiology for more than 40 years and associated with pioneering the Framingham Heart Study since it’s inception in 1949. In 1966, Dr. Kannel become Director, replacing Dr. Thomas R. Dawber, the original architect of the world famous study. He was also an attending physician at Boston University Medical Center and a member of the Evans Department of Medicine. Dr. Kannel is also trained in public health as well as in internal medicine and clinical cardiology. He has been associated with the National Heart, Lung and Blood Institute for over 35 years, and has had a long abiding interest in preventive cardiology for which he received the Dana Award in Preventive Medicine in 1972, the Dutch Einthoven Award in 1973, the Canadian Gairdner Award in 1976, the CIBA Award for Hypertension Research in 1981, the James D. Bruce Memorial Award of the American College of Physicians in 1982, and the Charles A. Dana Award for Pioneering Achievement in Health in 1986. He was named the University Lecturer of Boston University Medical Center in March, 1987. He received the 1988 Distinguished Service Award at the 37th Annual Convocation of the American College of Cardiology in March, 1988, the Award for Research in Hypertension from the National Conference on Cholesterol and Hypertension in 1991, the Bristol Myers Squibb Award for Distinguished Achievement in Cardiovascular Research in 1993, the Distinguished Alumnus Award from the University of Georgia Medical School in 1993, the Research Achievement Award from the American Heart Association in 1994, and the HealthTrac Foundation Fries Award in 1998. Dr. Kannel has also received a honorary medical degree from the University of Rio De Janeiro and an Honorary Doctor of Science Degree from the Medical College of Ohio. He is a past Chairman of the Council of Epidemiology of the American Heart Assocation and a past Chief of the Section of Preventive Medicine and Epidemiology in the Department of Medicine at Boston University Medical Center. He has held faculty appointments at Harvard Medical School and was a Senior Research Associate in the Center for Technology and Policy at Boston University.
Daniel Levy, M.D.
Director of the Framingham Heart Study. Dr. Levy is a fellow of the American College of Cardiology and an active member of the AHA Council on Hypertension and the American Society of Hypertension. In addition, Dr. Levy serves on the American College of Cardiology Committee on Hypertensive Diseases and National Cholesterol Education Program’s Adult Treatment Panel III (national cholesterol guidelines). He was a member of the Writing Committee for JNC VI (national hypertension guidelines). Dr. Levy is a medical officer of the National Heart, Lung, and Blood Institute and has a faculty appointment at Boston University School of Medicine. Dr. Levy has published over 200 articles in leading cardiovascular and scientific journals, as well as a book on the Framingham Heart Study. He serves on the editorial boards of Journal of American College of Cardiology, Hypertension, Journal of Hypertension, and the American Journal of Medicine. Dr Levy has been the recipient of many awards including the National Institutes of Health Director’s Award given for his research achievements at the Framingham Heart Study. His main areas of research interest include hypertension, left ventricular hypertrophy, heart failure, and the prevention of coronary heart disease. Dr. Levy serves as a Donald W. Reynolds Foundation Scholar. He is overseeing a Reynolds Center project in the Framingham Heart Study that seeks to identify genes for vascular stiffness.