A professor of medicine, conducts her research at the Framingham Heart Study, where she serves as Director of the Echocardiography and Vascular Function Laboratories. She has done research at the Framingham Study since 1988 on the epidemiology of atrial fibrillation, cardiac risk factors for stroke, and echocardiography. She is Principal Investigator on 3 RO1 grants investigating the relation of vascular function and inflammation to cardiovascular disease. She also serves as PI of the Framingham component of the Program on Genomic Applications Cardiogenomics Study examining the genetics of cardiac structure and function in collaboration with the MIT Whitehead Institute and Beth Israel Deaconess Medical Center.
R. Curtis Ellison, M.D.
A professor of medicine and public health, he is Chief of the Section of Preventive Medicine and Epidemiology. Dr. Ellison is Chairman of the Advisory Board of the Elizabeth Bishop Wine Resource Center at Boston University. He is a Fellow of the Council on Epidemiology and Prevention and the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association, and a member of the Council on Epidemiology and Prevention, International Society of Cardiology. He is the principal investigator of several NIH-funded studies dealing with the genetics of coronary heart disease, hypertension, and coronary calcification, and with the health effects of alcohol consumption.
Vasan S. Ramachandran, M.D.
A professor of medicine, is a senior investigator at the Framingham Heart Study where he serves as the Co-director of the Echocardiography Laboratory, Co-director of the Framingham Heart Study Fellowship program, and Co-chair of the Framingham Study DNA Committee. His research interests include: A) epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; B) population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling, including but not limited to role of natriuretic peptides, insulin resistance, cardiac extracellular matrix markers, oxidative stress, inflammation, growth factors; genetics of LV remodeling, LA and aortic structure and gene-environment interactions; brachial artery endothelial function, its correlates and tonometric assessment of large artery function; C) epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; large artery stiffness and function and role in systolic hypertension in the elderly; genetics of high blood pressure and large artery function; and D) exercise physiology, and exercise test responses in asymptomatic individuals and prognostic information; relations to endothelial function.