Accomplishments

Highlights of Accomplishments at Boston University Medical Center

1940

Reginald H. Smithwick, M.D., pioneers the surgical treatment of hypertension

1949

Robert W. Wilkins, M.D., and associates are first in the Western world to use reserpine-type drugs in the treatment of high blood pressure

1954

Step-care approach to the treatment of hypertension is formulated; Robert W. Wilkins, M.D., named President, American Heart Association

1958

BUMC research team first to uses the diuretic chlorothiazide for the treatment of patients with hypertension; Lasker Award to Robert W. Wilkins, M.D., for his work on anti-hypertensive drug therapy

1962

First to use the aldosterone antagonist spironolactone in the treatment of hypertension

1968

Pioneering work in development of extra-anatomic bypass procedures in peripheral vascular surgery

1971

Discovery of the hormone 18-hydroxy-deoxycorticosterone in genetic animal models of hypertension and humans

1977

First use of angiotensin converting enzyme inhibitor captopril in hypertension; first use of angiotensin converting enzyme inhibitors in heart failure

1978

Pioneering work to establish the use of a Left Ventricular Assist Device in Open Heart Surgery

1979

Continuing leadership in the long-standing Boston University/Framingham Heart Study, which identified the key risk factors associated with cardiovascular disease

1983

The first delineation of the vascular response to balloon angioplasty

1984

Thomas J. Ryan, M.D., named President, American Heart Association

1986

The first use of thermal laser angioplasty in humans

1994

First demonstration of deficiency of nitric oxide as a cause for thrombosis

1996

Elucidation of role of nitric oxide in salt sensitive hypertension

1998

Use of heparin-bonded cardiopulmonary bypass circuits to limit bleeding risk and ransfusion requirements for patients undergoing heart surgery

2000-2002

Identification of genetic polymorphisms that contribute to hypertension, thrombosis, and heart failure

2001

Role of glucose-6-phosphate dehydrogenase as a critical determinant of vascular oxidant stress

2002

Identification of novel molecular determinants of angiogenesis

2002

Identification of a molecular mechanism of adriamycin cardiotoxicity

2003

Use of glucose-insulin-potassium solution to improve outcome in diabetic patients undergoing coronary artery bypass surgery

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of BU School of Medicine