Rutao Cui, M.D., Ph.D.

rtAssociate Professor of Pharmacology and Dermatology, and Member, The Cancer Center; Director, The Laboratory of Skin Cancer Therapeutics (LSCT).

Ph.D., Shanghai Medical University, Shanghai, China; M.D., Shandong Medical University, Jinan, China.

Research Interests

Dr. Cui’s primary research interests include: understanding molecular mechanisms of melanoma development, defining the molecular effects of UVB radiation on melanocyte growth and differentiation, and developing murine genetic models for human melanoma.

Recent News

Selected Publications

Lu C, Chen J, Xu H, Zhou X, He Q, Li Y, Jiang G, Shan Y, Xue B, Zhao R, Wang Y, Werle KD, Cui R, Liang J, Xu Z. MIR106B and MIR93 Prevent Removal of Bacteria from Epithelial Cells by Disrupting ATG16L1-Mediated Autophagy. Gastroenterology, 2014 Jan; 146(1):188-99. PMID:24036151.

Cao J, Wan L, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu X, Wildund HR, Ryu B, Alani R, Dutton-Regester K, Goding CR, Hayward NK, Wei W, Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Molecular Cell, 2013 Aug 22; 51(4):409-22. PMID:23973372.

Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res. 2013 Ju 15; 73(14):4337-48. PMID:23650282.

Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper JS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 coactivators regulate Mitf and the tanning response. Molecular Cell, 2013, 49, 1-13. PMID: 23201126.

Liu F, Cao J, Sullivan K, Ryu B, Xu Z, Liu X, Cui R. Stat3 targeted therapies overcome the acquired resistance to vemurafenib in melanomas. Journal of Investigative Dermatology. 2013 AUG; 133(8):2041-9. PMID:23344460.

Liu F, Cao J, Pier E, Xu Z, Xu X, Goding C, Cui R. TBX2 expression is regulated by PAX3 in the melanocyte lineage. Pigment Cell and Melanoma Research, 2013 Jan; 26 (1): 67-77. PMID: 23020925.

Liu S, Tetzlaff M, Cui R, Xu X. miR-200c Inhibits Melanoma Progression and Drug Resistance through Down-Regulation of Bmi-1. Am J of Pathology, 2012, 181, 1823-1835. PMID: 22982443.

Dong L, Li Y, Cao J, Liu F, Pier E, Xu Z, Chen C, Wang R, Cui R*. FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription. Cell Death & Differentiation 2012, 19: 616-622. (* Corresponding author).

Dong L, Wen J, Zhang B, Dong F, Ziegler N, Mysz M, Armenta R, Cui R*. α-Melanocytes-stimulating Hormone enhances UV-induced DNA repair in keratinocytes by an XPA-dependent mechanism. Cancer Research, 2010, 70: 2971-2986. (* Corresponding author).

Yang G, Li Y, Nishimura E, Xin H, Zhou A, Guo Y, Dong L, Denning M, Nickoloff B, Cui R* Inhibition of PAX3 by TGF-β modulates melanocytes viability. Molecular Cell, 2008, 32: 554-563. (* Corresponding author).

Cui R, Widlund H, Feige E, Lin J, Wilensky D, Igras V, D’Orazio J, Fung F, Schanbacher C, Granter S, Fisher DE. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell, 2007, 128, 853-8642.

D’Orazio J, Nobuhisa J, Cui R, Arya M, Nishimura E, Spry M, Watsamatsu K, Ito S, Kunisada T, Granter S, Fisher DE. Melanocortin-1 signaling in UV induced pigmentation: molecular mimicking and skin protection. Nature 2006; 443: 340-345.

Accardi R, Dong W, Smet A, Cui R, Hautefeuille A, Gabet AS, Sylla BS, Gissmann L, Hainaut P, Tommasino M. Skin human papillomavirus type 38 alters p53 functions via accumulation of DeltaNp73. EMBO Reports, 2006; 7: 334-340.

Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, Barton MC. Family Members p53 and p73 Act Together in Chromatin Modification and Direct Repression of α-Fetoprotein Transcription. J Biol Chem. 2005; 280: 39152-60.1878.

Cui R*, He Jinchun, Zhang Fukui, Wang Baoen, Shen Hong, Li Yimei, and Chen Xiao Hong. Diagnostic Value for Protein Induced by Vitamin K Absence, Hepatoma- specific Band of Serum Gamma-glutamyl Transferase as Hepatocellular Carcinoma Markers Complementary to α- fetoprotein. British J of Cancer, 2003, 88, 1874- 1878. (* Corresponding author).

Contact

Office/Laboratory: Boston University School of Medicine, 72 East Concord Street, Room K-518, Boston, MA 02118

Phone: 617-414-1370
Fax: 617-638-4329

Email: rutaocui@bu.edu