People

 

10-3061-PHARMALABS-0028

Principal Investigator

10-3061-PHARMALABS-0014

Benjamin Wolozin, M.D./Ph.D.

Benjamin Wolozin completed his undergraduate education at Wesleyan University in Middletown, CT. He earned his M.D. and Ph.D. degrees from Albert Einstein College of Medicine, as part of the Medical Scientist Training Program. His postdoctoral fellowships were spent at Mt. Sinai Medical Center (1988-9) and the National Institute of Mental Health (1989–96). He joined Loyola University Medical Center in 1996 as an Associate Professor and rose to the rank of tenured full professor. He joined the Department of Pharmacology & Experimental Therapeutics at Boston University School of Medicine in 2004 as a Professor and also holds a secondary appointment in the Department of Neurology.

Dr. Wolozin is member of the Boston University Alzheimer’s Disease Center and the Boston University Parkinson’s disease and Movement Disorders Center. His interests focus on the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis. His work on Alzheimer’s disease examines the role of cholesterol in the pathophysiology of Alzheimer’s disease, and stems from his discovery in 2000 that subjects taking the cholesterol-lowering medicines, termed statins, have a lower incidence of Alzheimer’s disease. His work on Parkinson’s disease examines the interaction between genes implicated in the disease, such as LRRK2 and alpha-synuclein, and environmental factors implicated in the disease. His work on ALS focuses on the response of RNA metabolism and protein translation to stress. He uses multiple approaches to study neurodegenerative disease, ranging from molecular approaches to epidemiology. These approaches include molecular biology, cellular biology, transgenic mice, transgenic C. elegans, study of human brain samples and epidemiological database analyses.

At present, Dr. Wolozin serves as the primary investigator for several funded studies including, LRRK2 and Neurodegeneration, Interaction between genes and mitochondria in Parkinson’s disease, Stress granules and the biology of TDP-43, Development of Opticogenetic switches for mitochondrial function, and LRRK2 interactions with pathways linked to protein folding and degradation.

Dr. Wolozin has received numerous awards for his research including the Donald B. Lindsley Prize, Society for Neuroscience, the A. E. Bennett Award and a Merit Award from Alzforum. He is a member of the Scientific Advisory Board for Proteotech Pharmaceuticals and CMD Bioscience LLC, and is on the executive board for the Committee for Skeptical Inquiry. He also serves on numerous editorial boards, including the Journal of Biological Chemistry and Neurodegenerative Diseases, and is a standing member of the NIH CMND study section.

Senior Research Scientists

Saha Shamol Saha, PhD 

  • Research: C. elegans models expressing hLRRK2


Post-Doctoral Fellows

Julien Dusonchet, PhD 

  • Research:
Star Lee, PhD 

  • Research:
Liu-Yesucevitz Image Liqun Liu, PhD 

  • Research: The role of TDP-43 in stress granule biology and regulation of protein translation
Katherine_Youmans Katie Youmans, PhD 

  • Research: Modulation of RNA binding proteins in neurodegenerative diseases

 

Graduate Students

Boon Image Joon Boon 

  • Pharmacology (PhD)
  • Research: Identification of proteins that bind to and regulate LRRK2
aebata Atsushi Ebata 

  • Pathology (PhD)
  • Research:
  • The TDP-43 regulatory network system
  • C. elegans model expressing hTDP-43
Lin 2011-8-22 Image Amy Lin 

  • Pharmacology (PhD)
  • Research: the potential role of TDP-43 in mRNA regulation in stress granule
Trengrove_Chelsea_U159711242-150x150 Chelsea Trengrove 

  • Neuroscience (PhD)
  • Research: Regulation of LRRK2 localization and movment in neurons
Vanderweyde Image Tara Vanderweyde 

  • Pharmacology (PhD)
  • Research: Analysis of stress granule biology in Alzheimer’s disease

 

Master’s Students

brown.bike Isaac Goldszer 

  • Research: uses induced pluripotent stem cells from ALS patients with mutated forms of TDP-43 to study disease pathogenesis and test novel pharmaceuticals
Vivek Gowda 

  • Research: Interaction between LRRK2 and alpha-synuclein in C. elegans

 

Laboratory Technicians

Citro-150x150 Allison Citro 

  • Research:                                                                                       .

 

Undergraduate Students

Hentschel Alexander Hentschel
SONY DSC Maria Iuliano 

  • Research: Stress Granules in Alzheimer’s disease
Jennifer Watson