Publications

Qiu, WQ; Claunch, J; Nixon, EE; Fang, J; Li, M; Vangel, M and Hui, KK: The Effects of Acupuncture on the Brain Networks for Emotion and Cognition: An Observation of Gender Differences. Brain Research 2010, in press

Qiu, WQ ; Dean, MJ; Liu, TC; George, L; Gann, M; Cohen, J and Bruce, ML: Physical and Mental Health of the Homebound Elderly: An Overlooked Population. J Ameri Geria Soci 2010, in press

Sun, X; Bhadelia RA; Liebson, E; Bergethon P; Folstein, M; Zhu, JJ; Mwamburi; Patz, S and Qiu, WQ: The Relationship between Plasma Amyloid-β Peptides and the Medial Temporal Lobe in the Homebound Elderly. Int J. Ger Psych 2010, in press

Lai CQ, Parnell LD, Troen AM, Shen J, Caouette H, Warodomwichit D, Lee YC, Crott JW, Qiu, WQ, Rosenberg IH, Tucker KL, Ordovás JM: MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. Am J Clin Ntr 2010, 91: 1377-86, PMC2854908

Bhadelia RA, Price LL, Tedesco KL, Scott T, Qiu, WQ, Patz S, Folstein M, Rosenberg I, Caplan LR, Bergethon P: Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderly. Stroke 2009, 40: 3816-20, PMID: 19797696 (NIH#227973)

Okereke, OI; Xia, W; Irizarry, M. C; Sun, X; Qiu, WQ; Fagan, A. M; Mehta, P. D; Hyman, B. T; Selkoe, D. J; Grodstein, F: Performance Characteristics of Plasma Amyloid-Beta 40 and 42 Assays. Journal of Alzheimer’s Disease 2009, 16: 277-85, PMC2737811

Sun, X; Chiu, C.C; Liebson, E; Crivello, N. A; Wang, L; Folstein, M; Rosenberg, I; Mwamburi; Peter, I and Qiu, WQ: Depression and plasma Amyloid β peptides in the elderly with and without apolipoprotein E4 allele. Alzheimer’s Disease & Associated Disorder 2009, 23: 238-44, PMC2919337

Sun, X; Steffens, D.C; Folstein, M; Summergrad, P; Yee, J; Rosenberg, I; Au, R; Mwamburi, D.M and Qiu, WQ: Amyloid-associated depression: A prodromal depression of Alzheimer’s disease? Arch Gen Psych 2008, 65: 542-50, PMID: 18458206 (NIH#227968)

Folstein, M; Liu, T; Peters, I; Buell, J; Arsenault, A; Scott, TM and Qiu, WQ: The Homoecysteine Hypothesis of Depression: Ameri J. Psychiatry 2007; 164: 861-867.

Sun, X, Mwamburi, Bungay, K, Prasad, J, Yee, J, Lin, Y, Liu, TC, Summergrad, P, Folstein, M and Qiu, WQ: Depression, Antidepressants and Plasma Ab Peptides in those Elderly who do not have Cardiovascular Disease. Biological Psychiatry 2007; June 1

Qiu, WQ, Sun, X, Selkoe, DJ, Mwamburi, DM, Huang, T, Bhadela, R, Bergethon, P, Scott, TM, Summergrad, P, Wang, L, Rosenberg, I and Folstein, M: Depression is Associated with Low Plasma Ab42 Independently of Cardiovascular Disease in the Homebound Elderly. Int J. Ger Psych 2007; 22: 536-542

Farris, W, Schutz, S, Cirrito, JR, Shankar, G, Sun, XY, May, PC, George A, Leissring, MA, Walsh, D, Qiu, WQ, Holtzman DM and Selkoe, DJ: Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Precipitaes Cerebral Amyloid Angiopathy. Ameri J. Pathology 2007; 171: 241-251

Scott, TM; Peters, I; Tucker, KL; Arsenault, A; Bergethon, P; Bhadelia, R; Buell, J; Collins, L; Dashe, J; Griffith, J; Hibberd, P; Leins, D; Liu, T; Martin, A; Ordovas, J; Patz, S; Price, LL; Qiu, WQ; Sarnak, M; Selhub, J; Smaldone, L; Wang L; Wagner, C; Weiner, D; Rosenberg, I; Folstein, M: The Nutrition, Aging, and Memory in Elders (NAM) Study: Design and Methods for a Study of Micronutrients and Cognitive Function in a Homebound Elderly Population. Int J Geriatri Psychiatry 2006; 21: 519-528

Qiu, WQ, Price LL, Hibber P, Beull J, Collins L, Leins D, Mwamburi DM, Rosenberg, I, Smaldone BA, Scott TM, Siegel RD, Summergrad P, Sun X, Wagner C, Wang L, Yee J, Tucker K and Folstein M. Executive Dysfunction in Homebound Elderly with Diabetes J Ameri Geria Soci 2006; 54: 456-501.

Qiu, WQ and Folstein MF. Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer’s disease: review and hypothesis. Neurobiology of Aging 2006; 27: 190-198

Vekrellis K, Ye Z, Qiu, WQ, Walsh D, Harley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amylid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci 2000; 20(5): 1657-65.

Qiu, WQ, Walsh D, Ye Z, Vekrellis K, Zhang J, Podlisny M, Rosner M, Safavi A, Hersh LB, Selkoe DJ. Insulin degradation enzyme released from microglial cells degrades extracellular amyloid-beta peptide and stimulates its oligomerization. J Biol Chem. 1998; 273(49): 32730-32738.

Qiu, WQ, Ye Z, Kholodenko D, Seuber P, Selkoe DJ. Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural non-neural cells. J Biol Chem. 1997; 272 (10): 6641-6646.

Qiu, WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. J Biol Chem. 1996; 271(14): 8443-8451.

Kosik KS, Qiu, WQ, Greenberg SM. Cellular signaling pathway and cytoskeletal organization. Annals of the New York Academy of Sciences. 1995-1996 Vol 777: 114-120.

Greenberg SM, Qiu, WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neuroscience letter 1995; 198: 52-56.

Qiu, WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates hippocampal neuronal adhesion and neurite outgrowth in an isoform-dependent manner. J Neurosci. 1995; 15: 2157-67.

Greenberg SM, Koo EH, Selkoe DJ, Qiu, WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosporylation. Proc Antl Acad Sci USA. 1994; 91: 7104-8.

Feinman R, Qiu, WQ, Pearse RN, Nikolajczyk BS, Sen R, Sheffery M, Ravetch JV. PU.1 and an HLH family member contribute to the myeloid-specific transcribption of the Fc gamma RIIA promotor. EMBO J. 1994; 3852-60.

Hung AY, Hass C, Nitsch RM, Qiu, WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DF. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem. 1993; 268: 22595-62.

Qiu, WQ, deBruin D, Brownstein BH, Pearse R, Ravetch JV. Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science 1990; 248: 723-735.