Publications

Publications 2008-2010

  1. Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic Bis-styrylbenzenes as β-Amyloid Binding Ligands and Free Radical Scavengers. J Med Chem. 2010 Nov 1. [Epub ahead of print] PMID: 21038854
  2. Tokuraku K, Okuyama S, Matsushima K, Ikezu T, Kotani S. Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain. Neurosci Lett. 2010 Oct 29;484(2):143-7. Epub 2010 Aug 19.PMID: 20727942
  3. Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga SI, Ikezu T. Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. J Neurochem. 2010 May 21. [Epub ahead of print] PMID: 20492361
  4. Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J. 2010 Aug;24(8):3093-102. Epub 2010 Apr 6. PMID: 20371618
  5. Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB J. 2010 Aug;24(8):2904-15. Epub 2010 Mar 30. PMID: 20354135
  6. Tokuraku K, Marquardt M, Ikezu T. Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes. PLoS One. 2009 Dec 30;4(12):e8492.PMID: 20041162
  7. Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. PLoS One. 2009 Jul 10;4(7):e6197.PMID: 19593388
  8. Ikezu T. The aging of human-immunodeficiency-virus-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2009 Jun;4(2):161-2. Epub 2009 May 5. No abstract available. PMID: 19415503
  9. Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.  Mol Ther. 2009 May;17(5):803-9. Epub 2009 Mar 10.PMID: 19277012
  10. Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J Neurosci. 2008 Dec 31;28(53):14511-21.PMID: 19118186
  11. Buescher JL, Martinez LB, Sato S, Okuyama S, Ikezu T. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. J Neuroimmune Pharmacol. 2009 Mar;4(1):103-15. Epub 2008 Nov 25.PMID: 19034670
  12. Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. <http://www.ncbi.nlm.nih.gov/pubmed/19034669> J Neuroimmune Pharmacol. 2009 Mar;4(1):116-28. Epub 2008 Nov 26.PMID: 19034669
  13. Xu J, Ikezu T. The comorbidity of HIV-associated neurocognitive disorders and Alzheimer’s disease: a foreseeable medical challenge in post-HAART era. J Neuroimmune Pharmacol. 2009 Jun;4(2):200-12. Epub 2008 Nov 19. Review.PMID: 19016329
  14. Buescher JL, Gross S, Gendelman HE, Ikezu T. The neuropathogenesis of HIV-1 infection. Handb Clin Neurol. 2007;85:45-67. No abstract available. PMID: 18808975 [PubMed - in process]
  15. Buescher JL, Duan F, Sun J, Price RW, Ikezu T. OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients. J Neuroimmune Pharmacol. 2008 Dec;3(4):230-5. Epub 2008 Sep 5. PMID: 18773297
  16. Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. J Immunol. 2008 Sep 15;181(6):3877-86. PMID: 18768842
  17. Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol. 2008 Feb;172(2):521-33. Epub 2008 Jan 10.