Publications

Selected Publications 2010-2012

  1. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu TNat Neurosci. 2015 Oct 5. doi: 10.1038/nn.4132.
  2. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer’s disease. Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu TNeurobiol Aging. 2015 Aug 1. pii: S0197-4580(15)00393-0. doi: 10.1016/j.neurobiolaging.2015.07.027.
  3. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu TJ Neurosci. 2015 Jul 1;35(26):9764-81. doi: 10.1523/JNeurosci.4790-14.2015. PubMed PMID: 26134658; PubMed Central PMCID: PMC4571507.
  4. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. Ann Neurol. 2014 Sep;76(3):379-92. doi: 10.1002/ana.24219.
  5. Tau-tubulin kinase. Ikezu S, Ikezu TFront Mol Neurosci. 2014 Apr 28;7:33. doi: 10.3389/fnmol.2014.00033. eCollection 2014. Review. PubMed PMID: 24808823; PubMed Central PMCID: PMC4009424.
  6. The spectrum of disease in chronic traumatic encephalopathy. McKee AC, Stein TD, Nowinski CJ, Stern RA, Daneshvar DH, Alvarez VE, Lee HS, Hall G, Wojtowicz SM, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. Brain. 2012 Dec 2.
  7. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer’s disease brain. Varnum MM, Ikezu TArch Immunol Ther Exp (Warsz). 2012 Aug;60(4):251-66. doi: 10.1007/s00005-012-0181-2. Epub 2012 Jun 19. Review.
  8. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. J Neurosci. 2012 Jun 13;32(24):8270-83. doi: 10.1523/JNEUROSCI.1592-12.2012.
  9. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Sci Transl Med. 2012 May 16;4(134):134ra60. doi: 10.1126/scitranslmed.3003716.
  10. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer’s disease and has therapeutic implications for neurocognitive disorders. Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu TProc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1339-48. doi: 10.1073/pnas.1102349108. Epub 2011 Oct 31. Erratum in: Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21282.
  11. The spectrum of disease in chronic traumatic encephalopathy. McKee AC, Stein TD, Nowinski CJ, Stern RA, Daneshvar DH, Alvarez VE, Lee HS, Hall G, Wojtowicz SM, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. Brain. 2012 Dec 2.
  12.  The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer’s disease brain. Varnum MM, Ikezu T. Arch Immunol Ther Exp (Warsz). 2012 Aug;60(4):251-66. doi: 10.1007/s00005-012-0181-2. Epub 2012 Jun 19. Review.
  13.  Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. J Neurosci. 2012 Jun 13;32(24):8270-83. doi: 10.1523/JNEUROSCI.1592-12.2012.
  14.  Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Sci Transl Med. 2012 May 16;4(134):134ra60. doi: 10.1126/scitranslmed.3003716.
  15.  Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer’s disease? Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. J Alzheimers Dis. 2012;29(2):329-40. doi: 10.3233/JAD-2011-111472.
  16. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer’s disease and has therapeutic implications for neurocognitive disorders. Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1339-48. doi: 10.1073/pnas.1102349108. Epub 2011 Oct 31. Erratum in: Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21282. (2011) PMCID: PMC3241747.
  17.  AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice. Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T. Gene Ther. 2012 Jul;19(7):724-33. doi: 10.1038/gt.2011.126. Epub 2011 Sep 15.
  18.  The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer’s disease animal model. Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. J Neuroimmune Pharmacol. 2012 Jun;7(2):412-23. doi: 10.1007/s11481-011-9304-5. Epub 2011 Aug 9.
  19.  HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T. J Immunol. 2011 Jun 15;186(12):6925-32. doi: 10.4049/jimmunol.1100211. Epub 2011 May 6.
  20.  Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. J Med Chem. 2010 Nov 25;53(22):7992-9. doi: 10.1021/jm1006929. Epub 2010 Nov 1.
  21.  Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T. J Neurochem. 2011 Jan;116(2):192-204. doi: 10.1111/j.1471-4159.2010.06824.x.
  22.  CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice. Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. FASEB J. 2010 Aug;24(8):3093-102. doi: 10.1096/fj.10-155317. Epub 2010 Apr 6.
  23. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T. FASEB J. 2010 Aug;24(8):2904-15. doi: 10.1096/fj.09-150144. Epub 2010 Mar 30.
  24.  Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes. Tokuraku K, Marquardt M, Ikezu T. PLoS One. 2009 Dec 30;4(12):e8492. doi: 10.1371/journal.pone.0008492.